- The Mouse Cytomegalovirus Immediate-Early 1 Gene Is Not Required for Establishment of Latency or for Reactivation in the Lungs
[作者:Busche, A; Marquardt, A; Bleich, A; Ghazal, P; Angulo, A; Messerle, M,期刊:Journal of virology, 页码:4030-4038 , 文章类型: Article,,卷期:2009年83-9]
- The immediate-early protein IE1 of human and mouse cytomegalovirus (MCMV) is one of the first proteins expressed during the productive infection cycle and upon reactivation from latency. The CMV IE1 proteins have been fo...
- Ganglioside-Linked Terminal Sialic Acid Moieties on Murine Macrophages Function as Attachment Receptors for Murine Noroviruses
[作者:Taube, S; Perry, JW; Yetming, K; Patel, SP; Auble, H; Shu, LM; Nawar, HF; Lee, CH; Connell, TD; Shayman, JA; Wobus, CE,期刊:Journal of virology, 页码:4092-4101 , 文章类型: Article,,卷期:2009年83-9]
- Noroviruses are the major cause of nonbacterial gastroenteritis in humans. However, little is known regarding the norovirus life cycle, including cell binding and entry. In contrast to human noroviruses, the recently dis...
- Adenovirus Induction of IRF3 Occurs through a Binary Trigger Targeting Jun N-Terminal Kinase and TBK1 Kinase Cascades and Type I Interferon Autocrine Signaling
[作者:Nociari, M; Ocheretina, O; Murphy, M; Falck-Pedersen, E,期刊:Journal of virology, 页码:4081-4091 , 文章类型: Article,,卷期:2009年83-9]
- Pathogen recognition is a critical function of immune sentinel cells. Nave macrophages or dendritic cells (DCs) undergo pathogen-directed activation and maturation, and as mature antigen-presenting cells (APCs), they con...
- Essential Role for either TRS1 or IRS1 in Human Cytomegalovirus Replication
[作者:Marshall, EE; Bierle, CJ; Brune, W; Geballe, AP,期刊:Journal of virology, 页码:4112-4120 , 文章类型: Article,,卷期:2009年83-9]
- Viral infections often produce double-stranded RNA (dsRNA), which in turn triggers potent antiviral responses, including the global repression of protein synthesis mediated by protein kinase R (PKR) and 2'-5' oligoadenyl...
- Preclinical Studies of Human Immunodeficiency Virus/AIDS Vaccines: Inverse Correlation between Avidity of Anti-Env Antibodies and Peak Postchallenge Viremia
[作者:Zhao, J; Lai, LL; Amara, RR; Montefiori, DC; Villinger, F; Chennareddi, L; Wyatt, LS; Moss, B; Robinson, HL,期刊:Journal of virology, 页码:4102-4111 , 文章类型: Article,,卷期:2009年83-9]
- A major challenge for human immunodeficiency virus (HIV)/AIDS vaccines is the elicitation of anti-Env antibodies (Ab) capable of neutralizing the diversity of isolates in the pandemic. Here, we show that high-avidity, bu...
- NSs Protein of Rift Valley Fever Virus Induces the Specific Degradation of the Double-Stranded RNA-Dependent Protein Kinase
[作者:Habjan, M; Pichlmair, A; Elliott, RM; Overby, AK; Glatter, T; Gstaiger, M; Superti-Furga, G; Unger, H; Weber, F,期刊:Journal of virology, 页码:4365-4375 , 文章类型: Article,,卷期:2009年83-9]
- Rift Valley fever virus (RVFV) continues to cause large outbreaks of acute febrile and often fatal illness among humans and domesticated animals in Africa, Saudi Arabia, and Yemen. The high pathogenicity of this bunyavir...
- HLA Footprints on Human Immunodeficiency Virus Type 1 Are Associated with Interclade Polymorphisms and Intraclade Phylogenetic Clustering
[作者:Matthews, PC; Leslie, AJ; Katzourakis, A; Crawford, H; Payne, R; Prendergast, A; Power, K; Kelleher, AD; Klenerman, P; Carlson, J; Heckerman, D; Ndung'u, T; Walker, BD; Allen, TM; Pybus, OG; Goulder, PJR,期刊:Journal of virology, 页码:4605-4615 , 文章类型: Article,,卷期:2009年83-9]
- The selection of escape mutations has a major impact on immune control of infections with viruses such as human immunodeficiency virus (HIV). Viral evasion of CD8(+) T-cell responses leaves predictable combinations of es...
- Impact of Epitope Escape on PD-1 Expression and CD8 T-Cell Exhaustion during Chronic Infection
[作者:Blattman, JN; Wherry, EJ; Ha, SJ; van der Most, RG; Ahmed, R,期刊:Journal of virology, 页码:4386-4394 , 文章类型: Article,,卷期:2009年83-9]
- During some persistent viral infections, virus-specific T-cell responses wane due to the antigen-specific deletion or functional inactivation (i.e., exhaustion) of responding CD8 T cells. T-cell exhaustion often correlat...
- Primary B-Cell Infection with a Delta BALF4 Epstein-Barr Virus Comes to a Halt in the Endosomal Compartment yet Still Elicits a Potent CD4-Positive Cytotoxic T-Cell Response
[作者:Neuhierl, B; Feederle, R; Adhikary, D; Hub, B; Geletneky, K; Mautner, J; Delecluse, HJ,期刊:Journal of virology, 页码:4616-4623 , 文章类型: Article,,卷期:2009年83-9]
- Epstein-Barr virus (EBV) infection is mediated by several viral envelope glycoproteins. We have assessed gp110's functions during the virus life cycle using a mutant that lacks BALF4 (Delta BALF4). Exposure of various ce...
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