- Comparison of intravenous versus intraperitoneal administration of oncolytic herpes simplex virus 1 for peritoneal carcinomatosis in mice
[作者:Kulu, Y; Dorfman, JD; Kuruppu, D; Fuchs, BC; Goodwin, JM; Fujii, T; Kuroda, T; Lanuti, M; Tanabe, KK,期刊:Cancer gene therapy, 页码:291-297 , 文章类型: Article,,卷期:2009年16-4]
- hrR3 is an oncolytic herpes simplex virus 1 (HSV-1) mutant that replicates preferentially in tumors compared with normal tissues. Portal venous administration of hrR3 in mice bearing diffuse colorectal carcinoma liver me...
- PDGF-A promoter and enhancer elements provide efficient and selective antineoplastic gene therapy in multiple cancer types
[作者:Mishra, A; Ormerod, AK; Cibull, ML; Spear, BT; Kraner, SD; Kaetzel, DM,期刊:Cancer gene therapy, 页码:298-309 , 文章类型: Article,,卷期:2009年16-4]
- Development of antineoplastic gene therapies is impaired by a paucity of transcription control elements with efficient, cancer cell-specific activity. We investigated the utility of promoter (AChP) and 5'-distal enhancer...
- Adenovirus-mediated gene transfer of pathogen-associated molecular patterns for cancer immunotherapy
[作者:Tosch, C; Geist, M; Ledoux, C; Ziller-Remi, C; Paul, S; Erbs, P; Corvaia, N; Von Hoegen, P; Balloul, JM; Haegel, H,期刊:Cancer gene therapy, 页码:310-319 , 文章类型: Article,,卷期:2009年16-4]
- The delivery of stimulatory signals to dendritic cells (DCs) in the tumor microenvironment could be an effective means to break tumor-induced tolerance. The work presented here evaluates the immunostimulatory properties ...
- Preclinical study of an ex vivo gene therapy protocol for hepatocarcinoma
[作者:Lortal, B; Gross, F; Peron, JM; Penary, M; Berg, D; Hennebelle, I; Favre, G; Couderc, B,期刊:Cancer gene therapy, 页码:329-337 , 文章类型: Article,,卷期:2009年16-4]
- Preclinical studies in several animal models as well as clinical trials have shown a reduction in tumor growth following immunotherapy with interleukin-12 (IL-12). This cytokine is appropriate to test in therapeutic clin...
- High-dose chemotherapy augments the efficacy of recombinant adenovirus vaccines and improves the therapeutic outcome
[作者:Grinshtein, N; Ventresca, M; Margl, R; Bernard, D; Yang, TC; Millar, JB; Hummel, J; Beermann, F; Wan, Y; Bramson, JL,期刊:Cancer gene therapy, 页码:338-350 , 文章类型: Article,,卷期:2009年16-4]
- We have investigated the therapeutic potential of a prototypic melanoma vaccine based on recombinant adenovirus expressing human dopachrome tautomerase in the B16F10 murine melanoma model. We found that in the presence o...
- Downregulation of Wnt2 and beta-catenin by siRNA suppresses malignant glioma cell growth
[作者:Pu, P; Zhang, Z; Kang, C; Jiang, R; Jia, Z; Wang, G; Jiang, H,期刊:Cancer gene therapy, 页码:351-361 , 文章类型: Article,,卷期:2009年16-4]
- Increasing evidence suggests that aberrant activation of Wnt signaling is involved in tumor development and progression. Our earlier study on gene expression profile in human gliomas by microarray found that some members...
- Biodistribution of an oncolytic adenovirus after intracranial injection in permissive animals: a comparative study of Syrian hamsters and cotton rats
[作者:Sonabend, AM; Ulasov, IV; Han, Y; Rolle, CE; Nandi, S; Cao, D; Tyler, MA; Lesniak, MS,期刊:Cancer gene therapy, 页码:362-372 , 文章类型: Article,,卷期:2009年16-4]
- Conditionally replicative adenoviruses (CRAds) are often evaluated in mice; however, normal and cancerous mouse tissues are poorly permissive for human CRAds. As the cotton rat (CR) is a semipermissive animal and the Syr...
- Translational strategies exploiting TNF-alpha that sensitize tumors to radiation therapy
[作者:Mauceri, HJ; Beckett, MA; Liang, H; Sutton, HG; Pitroda, S; Galka, E; Efimova, E; Darga, T; Khodarev, NN; King, CR; Posner, MC; Hellman, S; Kufe, DW; Weichselbaum, RR,期刊:Cancer gene therapy, 页码:373-381 , 文章类型: Article,,卷期:2009年16-4]
- TNFerade is a radioinducible adenoviral vector expressing tumor necrosis factor-alpha (TNF-alpha) (Ad.Egr-TNF) currently in a phase III trial for inoperable pancreatic cancer. We studied B16-F1 melanoma tumors in TNF rec...
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