- Synergy of NMR, Computation, and X-Ray Crystallography for Structural Biology
[作者：Szymczyna, BR; Taurog, RE; Young, MJ; Snyder, JC; Johnson, JE; Williamson, JR,期刊：Structure, 页码：499-507 , 文章类型： Article，,卷期：2009年17-4]
- NMR spectroscopy and X-ray crystallography are currently the two most widely applied methods for the determination of macromolecular structures at high resolution. More recently, significant advances have been made in al...
- Structure, Assembly, and Mechanism of a PLP-Dependent Dodecameric L-Aspartate beta-Decarboxylase
[作者：Chen, HJ; Ko, TP; Lee, CY; Wang, NC; Wang, AHJ,期刊：Structure, 页码：517-529 , 文章类型： Article，,卷期：2009年17-4]
- The type-I PLP enzyme L-aspartate beta-decarboxylase converts aspartate to alanine and CO2. Similar to the homodimeric aminotransferases, its protein subunit comprises a large and a small domain, of 410 and 120 residues,...
- DNA Synthesis across an Abasic Lesion by Human DNA Polymerase iota
[作者：Nair, DT; Johnson, RE; Prakash, L; Prakash, S; Aggarwal, AK,期刊：Structure, 页码：530-537 , 文章类型： Article，,卷期：2009年17-4]
- Abasic sites are among the most abundant DNA lesions formed in human cells, and they present a strong block to replication. DNA polymerase iota (Pol iota) is one of the few DNA Pols that does not follow the A-rule opposi...
- Structural and Mutational Analyses of Deinococcus radiodurans UvrA2 Provide Insiqht into DNA Binding and Damage Recognition by UvrAs
[作者：Timmins, J; Gordon, E; Caria, S; Leonard, G; Acajjaoui, S; Kuo, MS; Monchois, V; McSweeney, S,期刊：Structure, 页码：547-558 , 文章类型： Article，,卷期：2009年17-4]
- UvrA proteins are key actors in DNA damage repair and play an essential role in prokaryotic nucleotide excision repair (NER), a pathway that is unique in its ability to remove a broad spectrum of DNA lesions. Understandi...
- Mediator Structural Conservation and Implications for the Regulation Mechanism
[作者：Cai, G; Imasaki, T; Takagi, Y; Asturias, FJ,期刊：Structure, 页码：559-567 , 文章类型： Article，,卷期：2009年17-4]
- Mediator, the multisubunit complex that plays an essential role in the regulation of transcription initiation in all eukaryotes, was isolated using an affinity purification protocol that yields pure material suitable for...
- Dynamic and Structural Characterization of a Bacterial FHA Protein Reveals a New Autoinhibition Mechanism
[作者：Barthe, P; Roumestand, C; Canova, MJ; Kremer, L; Hurard, C; Molle, V; Cohen-Gonsaud, M,期刊：Structure, 页码：568-578 , 文章类型： Article，,卷期：2009年17-4]
- The Odhl protein is key regulator of the TCA cycle in Corynebacterium glutamicum. This highly conserved protein is found in GC rich Gram-positive bacteria (e.g., the pathogenic Mycobacterium tuberculosis). The unphosphor...
- DNA Nanomechanics in the Nucleosome
[作者：Becker, NB; Everaers, R,期刊：Structure, 页码：579-589 , 文章类型： Article，,卷期：2009年17-4]
- The sequence-dependent mechanics of DNA-histone binding are essential for nucleosome positioning and mobility. Here we reanalyze nucleosome crystal structures in terms of the well-characterized base-pair scale DNA elasti...
- Structure and Function of Interacting IcmR-IcmQ Domains from a Type IVb Secretion System in Legionella pneumophila
[作者：Raychaudhury, S; Farelli, JD; Montminy, TP; Matthews, M; Menetret, JF; Dumenil, G; Roy, CR; Head, JF; Isberg, RR; Akey, CW,期刊：Structure, 页码：590-601 , 文章类型： Article，,卷期：2009年17-4]
- During infection, Legionella pneumophila creates a replication vacuole within eukaryotic cells and this requires a Type IVb secretion system (T4bSS). IcmQ plays a critical role in the translocase and associates with IcmR...
- The Crystal Structure of Cobra Venom Factor, a Cofactor for C3-and C5-Convertase CVFBb
[作者：Krishnan, V; Ponnuraj, K; Xu, YY; Macon, K; Volanakis, JE; Narayana, SVL,期刊：Structure, 页码：611-619 , 文章类型： Article，,卷期：2009年17-4]
Cobra venom factor (CVF) is a functional analog of human complement component C3b, the active fragment of C3. Similar to C3b, in human and mammalian serum, CVF binds factor B, which is then cleaved by factor D, giving...
- Molecular Evolution of Cystine-Stabilized Miniproteins as Stable Proteinaceous Binders
[作者：Chang, HJ; Hsu, HJ; Chang, CF; Peng, HP; Sun, YK; Yu, HM; Shih, HC; Song, CY; Lin, YT; Chen, CC; Wang, CH; Yang, AS,期刊：Structure, 页码：620-631 , 文章类型： Article，,卷期：2009年17-4]
- Small cystine-stabilized proteins are desirable scaffolds for therapeutics and diagnostics. Specific folding and binding properties of the proteinaceous binders can be engineered with combinatorial protein libraries in c...
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