- Syntheses and applications of fluorescent and biotinylated epolactaene derivatives: Epolactaene and its derivative induce disulfide formation.
[作者：Kuramochi, Kouji;Yukizawa, Shunsuke;Ikeda, Seiki;Sunoki, Takashi;Arai, Satoshi;Matsui, Rie;Morita, Akinori;Mizushina, Yoshiyuki;Sakaguchi, Kengo;Sugawara, Fumio;Ikekita, Masahiko;Kobayashi, Susumu;,期刊：Bioorganic & Medicinal Chemistry, 页码：5039-5049 , 文章类型： 研究论文，,卷期：2008年16-9]
- Epolactaene, isolated from cultured Penicillium sp. BM 1689-P mycelium, induces neurite outgrowth and arrests the cell cycle of the human neuroblastoma cell line, SH-SY5Y, at the G1 phase. The authors have found that e...
- Efficient synthesis of functionalized oligodeoxyribonucleotides with base-labile groups using a new silyl linker.
[作者：Ohkubo, Akihiro;Kasuya, Rintaro;Aoki, Katsufumi;Kobori, Akio;Taguchi, Haruhiko;Seio, Kohji;Sekine, Mitsuo;,期刊：Bioorganic & Medicinal Chemistry, 页码：5345-5351 , 文章类型： 研究论文，,卷期：2008年16-9]
- New 3'-terminal deoxyribonucleoside-loading reagents, e.g. I, with a new silyl-type linker are reported. These reagents could increase the efficiency of introduction of 3'-terminal deoxyribonucleoside components into po...
- Design, synthesis and trypanocidal activity of lead compounds based on inhibitors of parasite glycolysis.
[作者：Nowicki, Matthew W.;Tulloch, Lindsay B.;Worralll, Liam;McNae, Iain W.;Hannaert, Veronique;Michels, Paul A. M.;Fothergill-Gilmore, Linda A.;Walkinshaw, Malcolm D.;Turner, Nicholas J.;,期刊：Bioorganic & Medicinal Chemistry, 页码：5050-5061 , 文章类型： 研究论文，,卷期：2008年16-9]
- The glycolytic pathway has been considered a potential drug target against the parasitic protozoan species of Trypanosoma and Leishmania. The design and the synthesis of inhibitors targeted against Trypanosoma brucei ph...
- Trivalent, Gal/GalNAc-containing ligands designed for the asialoglycoprotein receptor.
[作者：Khorev, Oleg;Stokmaier, Daniela;Schwardt, Oliver;Cutting, Brian;Ernst, Beat;,期刊：Bioorganic & Medicinal Chemistry, 页码：5216-5231 , 文章类型： 研究论文，,卷期：2008年16-9]
- A series of novel, fluorescent ligands designed to bind with high affinity and specificity to the asialoglycoprotein receptor (ASGP-R) has been synthesized and tested on human liver cells. The compds. bear three non-red...
- S-Ribosylhomocysteine analogs with the carbon-5 and sulfur atoms replaced by a vinyl or (fluoro)vinyl unit.
[作者：Wnuk, Stanislaw F.;Lalama, Jennifer;Garmendia, Craig A.;Robert, Jenay;Zhu, Jinge;Pei, Dehua;,期刊：Bioorganic & Medicinal Chemistry, 页码：5090-5102 , 文章类型： 研究论文，,卷期：2008年16-9]
- Treatment of the protected ribose or xylose 5-aldehyde with sulfonyl-stabilized fluoro-phosphonate gave (fluoro)vinyl sulfones. Stannyl-desulfonylation followed by iodo-destannylation afforded 5,6-dideoxy-6-fluoro-6-iodo...
- An epoxidation mechanism of carbamazepine by CYP3A4.
[作者：Hata, Masayuki;Tanaka, Yoshikazu;Kyoda, Naoko;Osakabe, Taisuke;Yuki, Hitomi;Ishii, Itsuko;Kitada, Mitsukazu;Neya, Saburo;Hoshino, Tyuji;,期刊：Bioorganic & Medicinal Chemistry, 页码：5134-5148 , 文章类型： 研究论文，,卷期：2008年16-9]
- (CBZ). However, the epoxide is less stable in terms of potential energy than hydroxides of the six-membered arom. ring. To clarify the reason why CYP3A4 produces such an energetically unfavorable compd., the mechanism ...
- Modifying the N-terminus of polyamides: PyImPyIm has improved sequence specificity over f-ImPyIm.
[作者：Brown, Toni;Mackay, Hilary;Turlington, Mark;Sutterfield, Arden;Smith, Traci;Sielaff, Alan;Westrate, Laura;Bruce, Chrystal;Kluza, Jerome;O'Hare, Caroline;Nguyen, Binh;Wilson, W. David;Hartley, John A.;Lee, Moses;,期刊：Bioorganic & Medicinal Chemistry, 页码：5266-5276 , 文章类型： 研究论文，,卷期：2008年16-9]
- Seven N-terminus modified derivs. of a previously published minor-groove binding polyamide (f-ImPyIm, 1) were synthesized and the biochem. and biophys. chem. evaluated. These compds. were synthesized with the aim of att...
- Characterization of chemical components in extracts from Si-wu decoction with proliferation-promoting effects on rat mesenchymal stem cells.
[作者：Zeng, He-Ping;Wang, Ting-Ting;Chen, Wei;Wang, Chun-Yan;Chen, Dong-Feng;Shen, Jian-Gang;,期刊：Bioorganic & Medicinal Chemistry, 页码：5109-5114 , 文章类型： 研究论文，,卷期：2008年16-9]
- Si-wu decoction (SDE), a classic prescription in Traditional Chinese Medicine, has been used for the treatment of a variety of anemia in China for centuries. In order to explore the scientific basis of the formula, the ...
- Chemical and biological investigation of N-hydroxy-valdecoxib: An active metabolite of valdecoxib.
[作者：Erdelyi, Peter;Fodor, Tamas;Varga, Agnes Kis;Czugler, Matyas;Gere, Aniko;Fischer, Janos;,期刊：Bioorganic & Medicinal Chemistry, 页码：5322-5330 , 文章类型： 研究论文，,卷期：2008年16-9]
- The inhibition of cyclooxygenase enzymes plays an important role in the treatment of inflammatory diseases. A primary metabolite of the highly selective COX-2 inhibitor valdecoxib was synthesized and stabilized as its m...
- Interaction between artemisinin and heme. A Density Functional Theory study of structures and interaction energies.
[作者：Araujo, Jocley Queiroz;Carneiro, Jose Walkimar de Mesquita;de Araujo, Teixeira Martha;Leite, Franco Henrique Andrade;Taranto, Alex Gutterres;,期刊：Bioorganic & Medicinal Chemistry, 页码：5021-5029 , 文章类型： 研究论文，,卷期：2008年16-9]
- Malaria is an infectious disease caused by the unicellular parasite Plasmodium sp. Currently, the malaria parasite is becoming resistant to the traditional pharmacol. alternatives, which are ineffective. Artemisinin is ...
- Design, synthesis, and biological evaluation of glycine-based molecular tongs as inhibitors of Ab1-40 aggregation in vitro.
[作者：Cellamare, Saverio;Stefanachi, Angela;Stolfa, Diana A.;Basile, Teodora;Catto, Marco;Campagna, Francesco;Sotelo, Eddy;Acquafredda, Pasquale;Carotti, Angelo;,期刊：Bioorganic & Medicinal Chemistry, 页码：4810-4822 , 文章类型： 研究论文，,卷期：2008年16-9]
- A series of N-terminus benzamides of glycine-based sym. peptides, linked to m-xylylenediamine and 3,4'-oxydianiline spacers, were prepd. and tested as inhibitors of b-amyloid peptide Ab1-40 aggregation in vitro. Compds....
- Characterization, phase-solubility, and molecular modeling of inclusion complex of 5-nitroindazole derivative with cyclodextrins.
[作者：Jullian, Carolina;Morales-Montecinos, Javier;Zapata-Torres, Gerald;Aguilera, Benjamin;Rodriguez, Jorge;Aran, Vicente;Olea-Azar, Claudio;,期刊：Bioorganic & Medicinal Chemistry, 页码：5078-5084 , 文章类型： 研究论文，,卷期：2008年16-9]
- The slightly water-sol. 5-nitroindazole deriv. (5-NI) and its inclusion with either b-cyclodextrin (bCD) or Heptakis (2,6-di-O-methyl)-b-cyclodextrin (DMbCD) were investigated. The stoichiometric ratios and stability co...
- Synthesis and cytotoxic properties of new fluorodeoxyglucose-coupled chlorambucil derivatives.
[作者：Reux, Bastien;Weber, Valerie;Galmier, Marie-Josephe;Borel, Michele;Madesclaire, Michel;Madelmont, Jean-Claude;Debiton, Eric;Coudert, Pascal;,期刊：Bioorganic & Medicinal Chemistry, 页码：5004-5020 , 文章类型： 研究论文，,卷期：2008年16-9]
- Frequently used in the treatment of malignant cells, alkylating agents, like most anticancer substances, produce adverse side effects caused by the toxicity of the agents toward normal tissues and lose efficiency through...
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