- Synthesis and antiviral activity of novel pyrazole derivatives containing oxime esters group.
[作者:Ouyang, Guiping;Chen, Zhuo;Cai, Xue-Jian;Song, Bao-An;Bhadury, Pinaki S.;Yang, Song;Jin, Lin-Hong;Xue, Wei;Hu, De-Yu;Zeng, Song;,期刊:Bioorganic & Medicinal Chemistry, 页码:9699-9707 , 文章类型: 研究论文,,卷期:2008年16-22]
- Fourteen title compds., 1-substituted-5-substitutedphenylthio-4-pyrazolaldoxime ester derivs. 4a-4n, were synthesized from the starting material 1-substitutedphenyl-3-methyl-5-substitutedphenylthio-4-pyrazolaldoxime s 3 ...
- 1,3-Dialkyl-8-(hetero)aryl-9-OH-9-deazaxanthines as potent A2B adenosine receptor antagonists: Design, synthesis, structure-affinity and structure-selectivity relationships.
[作者:Stefanachi, Angela;Nicolotti, Orazio;Leonetti, Francesco;Cellamare, Saverio;Campagna, Francesco;Loza, Maria Isabel;Brea, Jose Manuel;Mazza, Fernando;Gavuzzo, Enrico;Carotti, Angelo;,期刊:Bioorganic & Medicinal Chemistry, 页码:9780-9789 , 文章类型: 研究论文,,卷期:2008年16-22]
- A no. of 1,3-dialkyl-8-(hetero)aryl-9-OH-9-deazaxanthines were prepd. and evaluated as ligands of recombinant human adenosine receptors (hARs). Several 1,3-di-Pr derivs. endowed with nanomolar binding affinity at hA2B r...
- Synthesis, mechanistic studies, and anti-proliferative activity of glutathione/glutathione S-transferase-activated nitric oxide prodrugs.
[作者:Chakrapani, Harinath;Kalathur, Ravi C.;Maciag, Anna E.;Citro, Michael L.;Ji, Xinhua;Keefer, Larry K.;Saavedra, Joseph E.;,期刊:Bioorganic & Medicinal Chemistry, 页码:9764-9771 , 文章类型: 研究论文,,卷期:2008年16-22]
- Nitric oxide (NO) prodrugs such as O 2-(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate (JS-K) are a growing class of promising NO-based therapeutics. Nitric oxide release from the anti-c...
- Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B.
[作者:La Regina, Giuseppe;Silvestri, Romano;Gatti, Valerio;Lavecchia, Antonio;Novellino, Ettore;Befani, Olivia;Turini, Paola;Agostinelli, Enzo;,期刊:Bioorganic & Medicinal Chemistry, 页码:9729-9740 , 文章类型: 研究论文,,卷期:2008年16-22]
- New monoamine oxidase inhibitors were synthesized as indole analogs of a previously reported pyrrole series. Several compds. were potent MAO-A (12, 17, 19-22, 31, 36, and 37) or MAO-B (14, 20, 24, 38, 44, and 46) inhibi...
- Design, synthesis and antitumor evaluation of novel thalidomide dithiocarbamate and dithioate analogs against Ehrlich ascites carcinoma-induced solid tumor in Swiss albino mice.
[作者:Zahran, Magdy A.-H.;Salem, Tarek A.-R.;Samaka, Rehab M.;Agwa, Hussein S.;Awad, Ayman R.;,期刊:Bioorganic & Medicinal Chemistry, 页码:9708-9718 , 文章类型: 研究论文,,卷期:2008年16-22]
- sulfur atoms 2 and 4-18, resp., were designed and synthesized. These compds. were screened for in vitro antitumor activity against Ehrlich ascites carcinoma (EAC) cell line and exhibited potent cytotoxic activity. On t...
- 3D-QSAR studies of heterocyclic quinones with inhibitory activity on vascular smooth muscle cell proliferation using pharmacophore-based alignment.
[作者:Ryu, Chung-Kyu;Lee, Yoonji;Park, Seul-gi;You, Hea-Jung;Lee, Ra-Young;Lee, Seung-Yon;Choi, Sun;,期刊:Bioorganic & Medicinal Chemistry, 页码:9772-9779 , 文章类型: 研究论文,,卷期:2008年16-22]
- The abnormal proliferation and migration of vascular smooth muscle cells (SMCs) play an important role in the pathol. of coronary artery atherosclerosis and restenosis following angioplasty. It was reported that some he...
- Structure-activity relationship of antibacterial chalcones.
[作者:Avila, Hugo Pereira;Smania, Elza de Fatima Albino;Delle Monache, Franco;Smania, Artur, Jr.;,期刊:Bioorganic & Medicinal Chemistry, 页码:9790-9794 , 文章类型: 研究论文,,卷期:2008年16-22]
- The antibacterial activity of 31 chalcones was tested against Bacillus cereus ATCC 11778, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, and Staphylococcus aureus ATCC 25923. Some of the chalcones showed...
- The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis.
[作者:Diaz-Carballo, David;Malak, Sascha;Bardenheuer, Walter;Freistuehler, Michael;Reusch, H. Peter;,期刊:Bioorganic & Medicinal Chemistry, 页码:9635-9643 , 文章类型: 研究论文,,卷期:2008年16-22]
- Increasing efforts are directed toward finding applications for natural products and their derivs. in the treatment of human diseases. Among such products, propolis, a resinous substance produced by honey bees from vari...
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