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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共17条记录   Terpenoids: Opportunities for biosynthesis of natural product drugs using engineered microorganisms [作者：Ajikumar, PK; Tyo, K; Carlsen, S; Mucha, O; Phon, TH; Stephanopoulos, G,期刊：Molecular Pharmaceutics, 页码：167-190 , 文章类型： Review，,卷期：2008年5-2] Terpenoids represent a diverse class of molecules that provide a wealth of opportunities to address many human health and societal issues. The expansive array of structures and functionalities that have been evolved in n... Nonribosomal peptide synthetases involved in the production of medically relevant natural products [作者：Felnagle, EA; Jackson, EE; Chan, YA; Podevels, AM; Berti, AD; McMahon, MD; Thomas, MG,期刊：Molecular Pharmaceutics, 页码：191-211 , 文章类型： Review，,卷期：2008年5-2] Natural products biosynthesized wholly or in part by nonribosomal peptide synthetases (NRPSs) are some of the most important drugs currently used clinically for the treatment of a variety of diseases. Since the initial r... Bacterial hosts for natural product production [作者：Zhang, H; Wang, Y; Pfeifer, BA,期刊：Molecular Pharmaceutics, 页码：212-225 , 文章类型： Review，,卷期：2008年5-2] Four bacterial hosts are reviewed in the context of either native or heterologous natural product production. E, coli, B. subtilis, pseudomonads, and Streptomyces bacterial systems are presented with each having either a... Diversity of polyketide synthases found in the Aspergillus end Streptomyces genomes [作者：Sanchez, JF; Chiang, YM; Wang, CCC,期刊：Molecular Pharmaceutics, 页码：226-233 , 文章类型： Review，,卷期：2008年5-2] Natural products produced by biological organisms have played an important role in human health. The genomes of several Aspergillus species and several Streptomyces species have recently been sequenced. Interestingly the... In vivo and in vitro production options for fungal secondary metabolites [作者：Schneider, P; Misiek, M; Hoffmeister, D,期刊：Molecular Pharmaceutics, 页码：234-242 , 文章类型： Review，,卷期：2008年5-2] Microbial natural products, among them a vast diversity of fungal origin, represent a major source for new drug candidates. Focusing on fungal metabolites, our review covers recent advances in the field of biotransformat... Pharmaceutically active natural product synthesis and supply via plant cell culture technology [作者：Kolewe, ME; Gaurav, V; Roberts, SC,期刊：Molecular Pharmaceutics, 页码：243-256 , 文章类型： Review，,卷期：2008年5-2] The chemical diversity of plant-derived natural products allows them to function in a multitude of ways including flavor enhancers, agricultural chemicals, and importantly, human medicinals. Supply of pharmaceutically ac... A delineation of diketopiperazine self-assembly processes: Understanding the molecular events involved in N-epsilon-(Fumaroyl)diketopiperazine of L-Lys (FDKP) interactions [作者：Kaur, N; Zhou, B; Breitbeil, F; Hardy, K; Kraft, KS; Trantcheva, I; Phanstiel, O,期刊：Molecular Pharmaceutics, 页码：294-315 , 文章类型： Article，,卷期：2008年5-2] The N-epsilon-fumaroylated diketopiperazine of L-Lys (FDKP, 1) self-assembles into microparticles that can be used for pulmonary drug delivery. When these particles are formulated with insulin, the resultant powder (Tech... Biodistribution, clearance, and biocompatibility of iron oxide magnetic nanoparticles in rats [作者：Jain, TK; Reddy, MK; Morales, MA; Leslie-Pelecky, DL; Labhasetwar, V,期刊：Molecular Pharmaceutics, 页码：316-327 , 文章类型： Article，,卷期：2008年5-2] It is essential to determine the biodistribution, clearance, and biocompatibility of magnetic nanoparticles (MNPs) for in vivo biomedical applications to ensure their safe clinical use. We have studied these aspects with... Mathematical modeling off corticosteroid pharmacogenomics in rat muscle following acute and chronic methylprednisolone dosing [作者：Yao, Z; Hoffman, EP; Ghimbovschi, S; DuBois, DC; Almon, RR; Jusko, WJ,期刊：Molecular Pharmaceutics, 页码：328-339 , 文章类型： Article，,卷期：2008年5-2] The pharmacogenomic effects of a corticosteroid (CS) were assessed in rat skeletal muscle using microarrays. Adrenalectomized (ADX) rats were treated with methylprednisolone (MPL) by either 50 mg/kg intravenous injection... Strain improvement of recombinant Escherichia coli for efficient production of plant flavonoids [作者：Leonard, E; Yan, Y; Fowler, ZL; Li, Z; Lim, CG; Lim, KH; Koffas, MAG,期刊：Molecular Pharmaceutics, 页码：257-265 , 文章类型： Article，,卷期：2008年5-2] Plant flavonoid polyphenols continue to find increasing pharmaceutical and nutraceutical applications; however their isolation, especially of pure compounds, from plant material remains an underlying challenge. In the pa... Biodegradable, cationic methacrylamide-based polymers for gene delivery to ovarian cancer cells in mice [作者：de Wolf, HK; Luten, J; Snel, CJ; Storm, G; Hennink, WE,期刊：Molecular Pharmaceutics, 页码：349-357 , 文章类型： Article，,卷期：2008年5-2] A series of cationic, methacrylamide polymers was tested for use as a biodegradable gene carrier in ovarian cancer. Tumor transfection activity of polyplexes consisting of a reporter gene and different methacrylamide pol... Supramolecular nanoencapsulation as a tool: Solubilization of the anticancer drug trans-dichloro(dipyridine)platinum(II) by complexation with beta-cyclodextrin [作者：Horvath, G; Premkumar, T; Boztas, A; Lee, E; Jon, S; Geckeler, KE,期刊：Molecular Pharmaceutics, 页码：358-363 , 文章类型： Article，,卷期：2008年5-2] A novel, water-soluble trans-platinum complex was synthesized by inclusion complexation with beta-cyclodextrin. The complexation was confirmed by H-1 NMR, FTIR, TGA, and XRD as well as by SEM and EDX. As the precursor co... Predicting intrinsic aqueous solubility by a thermodynamic cycle [作者：Palmer, DS; Llinas, A; Morao, I; Day, GM; Goodman, JM; Glen, RC; Mitchell, JBO,期刊：Molecular Pharmaceutics, 页码：266-279 , 文章类型： Article，,卷期：2008年5-2] We report methods to predict the intrinsic aqueous solubility of crystalline organic molecules from two different thermodynamic cycles. We find that direct computation of solubility, via ab initio calculation of thermody... A nanoemulsion formulation of tamoxifen increases its efficacy in a breast cancer cell line [作者：Tagne, JB; Kakumanu, S; Ortiz, D; Shea, T; Nicolosi, RJ,期刊：Molecular Pharmaceutics, 页码：280-286 , 文章类型： Article，,卷期：2008年5-2] This paper reports on the preparation of a water-soluble nanoemulsion of the highly lipid-soluble drug tamoxifen (TAM). In addition, relative to a suspension of TAM, the nanoemulsion preparation demonstrated a greater ze... New ways of imaging uptake and intracellular fate of liposomal drug carrier systems inside individual cells, based on Raman microscopy [作者：Matthaeus, C; Kale, A; Chernenko, T; Torchilin, V; Diem, M,期刊：Molecular Pharmaceutics, 页码：287-293 , 文章类型： Article，,卷期：2008年5-2] Recent developments, combining Raman spectroscopy with optical microscopy, provide a new noninvasive technique to assess and image cellular processes. Of particular interest are the uptake mechanisms of various cytologic... Characterization of gastrointestinal drug absorption in cynomolgus monkeys [作者：Takahashi, M; Washio, T; Suzuki, N; Igeta, K; Fujii, Y; Hayashi, M; Shirasaka, Y; Yamashita, S,期刊：Molecular Pharmaceutics, 页码：340-348 , 文章类型： Article，,卷期：2008年5-2] Possible factors of species differences in gastrointestinal drug absorption between cynomolgus monkeys and humans were examined using several commercial drugs. Oral bioavailability (BA) of acetaminophen, furosemide, and ...