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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共22条记录   Amorphous Compositions Using Concentration Enhancing Polymers for Improved Bioavailability of Itraconazole [作者：DiNunzio, JC; Miller, DA; Yang, W; McGinity, JW; Williams, RO,期刊：Molecular Pharmaceutics, 页码：968-980 , 文章类型： Article，,卷期：2008年5-6] Amorphous engineered particle compositions of itraconazole (ITZ) and potential concentration enhancing polymers, cellulose acetate phthalate (CAP) and polyvinyl acetate phthalate (PVAP), were produced by ultra-rapid free... Enhanced Bioavailability of a Poorly Soluble VR1 Antagonist Using an Amorphous Solid Dispersion Approach: A Case Study [作者：Kennedy, M; Hu, J; Gao, P; Li, L; Ali-Reynolds, A; Chal, B; Gupta, V; Ma, C; Mahajan, N; Akrami, A; Surapaneni, S,期刊：Molecular Pharmaceutics, 页码：981-993 , 文章类型： Article，,卷期：2008年5-6] Amorphous solid dispersions (ASD) of a poorly soluble water-soluble VR1 antagonist (AMG 517) were explored for improving physical stability and in vivo exposure. AMG 517 was incorporated at 15 or 50 wt % into polymeric m... Caspase-3 Gene Silencing for Inhibiting Apoptosis in Insulinoma Cells and Human Islets [作者：Cheng, GF; Zhu, L; Mahato, RI,期刊：Molecular Pharmaceutics, 页码：1093-1102 , 文章类型： Article，,卷期：2008年5-6] Although islet transplantation has great potential to treat type I diabetes, most islet grafts do not function due to the host immune rejection, nonspecific inflammatory response and poor revascularization. Since caspase... Modeling Free Energies of Solvation in Olive Oil [作者：Chamberlin, AC; Levitt, DG; Cramer, CJ; Truhlar, DG,期刊：Molecular Pharmaceutics, 页码：1064-1079 , 文章类型： Review，,卷期：2008年5-6] Olive oil partition coefficients are useful for modeling the bioavailability of drug-like compounds. We have recently developed an accurate solvation model called SM8 for aqueous and organic solvents (Marenich, A. V.; Ol... Application of Melt Extrusion in the Development of a Physically and Chemically Stable High-Energy Amorphous Solid Dispersion of a Poorly Water-Soluble Drug [作者：Lalkshman, JP; Cao, Y; Kowalski, J; Serajuddin, ATM,期刊：Molecular Pharmaceutics, 页码：994-1002 , 文章类型： Article，,卷期：2008年5-6] Formulation of active pharmaceutical ingredients (API) in high-energy amorphous forms is a common strategy to enhance solubility, dissolution rate and, consequently, oral bioavailability of poorly water-soluble drugs. Am... Monitoring the Biodegradation of Dendritic Near-Infrared Nanoprobes by in Vivo Fluorescence Imaging [作者：Almutairi, A; Akers, WJ; Berezin, MY; Achilefu, S; Frechet, JMJ,期刊：Molecular Pharmaceutics, 页码：1103-1110 , 文章类型： Article，,卷期：2008年5-6] Synthetic polymers and dendrimers have been widely used by the medical community to overcome biological barriers and enhance in vivo biomedical applications. Despite the widespread use of biomaterials it has been general... Surface-Enhanced Crystallization of Amorphous Nifedipine [作者：Zhu, L; Wong, L; Yu, L,期刊：Molecular Pharmaceutics, 页码：921-926 , 文章类型： Article，,卷期：2008年5-6] Amorphous solids are generally more soluble and faster dissolving than their crystalline counterparts, a property useful for delivering poorly soluble drugs. Amorphous drugs must be stable against crystallization, for cr... Hydroxypropyl Methylcellulose Acetate Succinate-Based Spray-Dried Dispersions: An Overview [作者：Friesen, DT; Shanker, R; Crew, M; Smithey, DT; Curatolo, WJ; Nightingale, JAS,期刊：Molecular Pharmaceutics, 页码：1003-1019 , 文章类型： Article，,卷期：2008年5-6] Spray-dried dispersions (SDDs) of low-solubility drugs have been prepared using the polymer hydroxypropyl methylcellulose acetate succinate (HPMCAS). For a variety of drug structures, these SDDs provide supersaturation i... Varying the Chain Length in N-4,N-9-Diacyl Spermines: Non-Viral Lipopolyamine Vectors for Efficient Plasmid DNA Formulation [作者：Ghonaim, HM; Ahmed, OAA; Pourzand, C; Blaubrouih, IS,期刊：Molecular Pharmaceutics, 页码：1111-1121 , 文章类型： Article，,卷期：2008年5-6] The aims of this work are to study the effect of varying the chain length in synthesized N-4,N-9-diacyl spermines on DNA condensation and then to compare their transfection efficiencies in cell lines. The five novel N-4,... Thermodynamics, Molecular Mobility and Crystallization Kinetics of Amorphous Griseofulvin [作者：Zhou, D; Zhang, GGZ; Law, D; Grant, DJW; Schmitt, EA,期刊：Molecular Pharmaceutics, 页码：927-936 , 文章类型： Article，,卷期：2008年5-6] Griseofulvin is a small rigid molecule that shows relatively high molecular mobility and small configurational entropy in the amorphous phase and tends to readily crystallize from both rubbery and glassy states. This wor... Molecular Dynamics Simulations of Functional Group Effects on Solvation Thermodynamics of Model Solutes in Decane and Tricaprylin [作者：Rane, SS; Anderson, BD,期刊：Molecular Pharmaceutics, 页码：1023-1036 , 文章类型： Article，,卷期：2008年5-6] Triglycerides and related fatty acid esters constitute a large percentage of the lipid excipients employed in the development of lipid-based drug formulations. Computer simulations can provide useful information on the s... IgG-Paraoxonase-1 Fusion Protein for Targeted Drug Delivery across the Human Blood-Brain Barrier [作者：Boado, RJ; Zhang, Y; Zhang, YF; Wang, YT; Pardridge, WM,期刊：Molecular Pharmaceutics, 页码：1037-1043 , 文章类型： Article，,卷期：2008年5-6] Paraoxonase (PON)-1 is the most potent human protein with organophosphatase activity against organophosphate (OP) toxins. OP compounds readily cross the blood-brain barrier (131313) and have lethal mechanisms of action w... Targeted Disruption of Peptide Transporter Pept1 Gene in Mice Significantly Reduces Dipeptide Absorption in Intestine [作者：Hu, YG; Smith, DE; Ma, K; Jappar, D; Thomas, W; Hillgren, KM,期刊：Molecular Pharmaceutics, 页码：1122-1130 , 文章类型： Article，,卷期：2008年5-6] PEPT1 is a high-capacity, low-affinity peptide transporter that mediates the uptake of di- and tripeptides in the intestine and kidney. PEPT1 also has significance in its ability to transport therapeutic agents and becau... FTIR Studies on Differential Intermolecular Association in Crystalline and Amorphous States of Structurally Related Non-Steroidal Anti-Inflammatory Drugs [作者：Kaushal, AM; Chakraborti, AK; Bansal, AK,期刊：Molecular Pharmaceutics, 页码：937-945 , 文章类型： Article，,卷期：2008年5-6] Information on molecular interactions critically impacts the physical stability and "stabilization" strategy for the amorphous state of pharmaceuticals. The present study was designed to understand the differences in int... Targeted Nanoassembly Loaded with Docetaxel Improves Intracellular Drug Delivery and Efficacy in Murine Breast Cancer Model [作者：Gao, Y; Chen, LL; Gu, WW; Xi, Y; Lin, LP; Li, YP,期刊：Molecular Pharmaceutics, 页码：1044-1054 , 文章类型： Article，,卷期：2008年5-6] Docetaxel is one of the most promising chemotherapeutic agents for the treatment of metastatic breast cancer, but it shows tearful side effects. We hypothesized that a novel targeted nanoassembly (TNA) could provide effi... Controlling Plasma Protein Binding: Structural Correlates of Interactions of Hydrophobic Polyamine Endotoxin Sequestrants with Human Serum Albumin [作者：Nguyen, TB; Kumar, EVKS; Sil, D; Wood, SJ; Miller, KA; Warshakoon, HJ; Datta, A; David, SA,期刊：Molecular Pharmaceutics, 页码：1131-1137 , 文章类型： Article，,卷期：2008年5-6] Hydrophobically substituted polyamine compounds, particularly N-acyl or N-alkyl derivatives of homospermine, are potent endotoxin (lipopolysaccharide) sequestrants. Despite their polycationic nature, the aqueous solubili...