- RelA Ser(276) phosphorylation is required for activation of a subset of NF-kappa B-dependent genes by recruiting cyclin-dependent kinase 9/cyclin T1 complexes
[作者:Nowak, DE; Tian, B; Jamaluddin, M; Boldogh, I; Vergara, LA; Choudhary, S; Brasier, AR,期刊:Molecular and Cellular Biology, 页码:3623-3638 , 文章类型: Article,,卷期:2008年28-11]
- NF-kappa B plays a central role in cytokine-inducible inflammatory gene expression. Previously we empirically determined the identity of 92 members of the genetic network under direct NF-kappa B/RelA control that show ma...
- alpha PIX Rho GTPase guanine nucleotide exchange factor regulates lymphocyte functions and antigen receptor signaling
[作者:Missy, K; Hu, B; Schilling, K; Harenberg, A; Sakk, V; Kuchenbecker, K; Kutsche, K; Fischer, KD,期刊:Molecular and Cellular Biology, 页码:3776-3789 , 文章类型: Article,,卷期:2008年28-11]
- alpha PIX is a Rho GTPase guanine nucleotide exchange factor domain-containing signaling protein that associates with other proteins involved in cytoskeletal-membrane complexes. It has been shown that PIX proteins play r...
- Hypoxia-inducible factor-dependent degeneration, failure, and malignant transformation of the heart in the absence of the von Hippel-Lindau protein
[作者:Lei, L; Mason, S; Liu, DG; Huang, Y; Marks, C; Hickey, R; Jovin, IS; Pypaert, M; Johnson, RS; Giordano, FJ,期刊:Molecular and Cellular Biology, 页码:3790-3803 , 文章类型: Article,,卷期:2008年28-11]
- Hypoxia-inducible transcription factor 1 (HIF-1) and HIF-2 alpha regulate the expression of an expansive array of genes associated with cellular responses to hypoxia. Although HIF-regulated genes mediate crucial benefici...
- The silent information regulator 3 protein, SIR3p, binds to chromatin fibers and assembles a hypercondensed chromatin architecture in the presence of salt
[作者:McBryant, SJ; Krause, C; Woodcock, CL; Hansen, JC,期刊:Molecular and Cellular Biology, 页码:3563-3572 , 文章类型: Article,,卷期:2008年28-11]
- The telomeres and mating-type loci of budding yeast adopt a condensed, heterochromatin-like state through recruitment of the silent information regulator (SIR) proteins SIR2p, SIR3p, and SIR4p. In this study we character...
- Musashil modulates mammary progenitor cell expansion through proliferin-mediated activation of the Wnt and Notch pathways
[作者:Wang, XY; Yin, YZ; Yuan, HY; Sakamaki, T; Okano, H; Glazer, RI,期刊:Molecular and Cellular Biology, 页码:3589-3599 , 文章类型: Article,,卷期:2008年28-11]
- The RNA-binding protein Musashi1 (Msi1) is a positive regulator of Notch-mediated transcription in Drosophila melanogaster and neural progenitor cells and has been identified as a putative human breast stem cell marker. ...
- Cyclic AMP (cAMP)-mediated stimulation of adipocyte differentiation requires the synergistic action of Epac- and cAMP-dependent protein kinase-dependent processes
[作者:Petersen, RK; Madsen, L; Pedersen, LM; Hallenborg, P; Hagland, H; Viste, K; Doskeland, SO; Kristiansen, K,期刊:Molecular and Cellular Biology, 页码:3804-3816 , 文章类型: Article,,卷期:2008年28-11]
- Cyclic AMP (cAMP)-dependent processes are pivotal during the early stages of adipocyte differentiation. We show that exchange protein directly activated by cAMP (Epac), which functions as a guanine nucleotide exchange fa...
- Vitamin D-dependent recruitment of corepressors to vitamin D/retinoid X receptor heterodimers
[作者:Sanchez-Martinez, R; Zambrano, A; Castillo, AI; Aranda, A,期刊:Molecular and Cellular Biology, 页码:3817-3829 , 文章类型: Article,,卷期:2008年28-11]
- Transcriptional regulation by nuclear receptors is mediated by recruitment of coactivators and corepressors. In the classical model, unliganded nonsteroidal receptors bind corepressors, such as the silencing mediator of ...
- Protein kinase D1 stimulates MEF2 activity in skeletal muscle and enhances muscle performance
[作者:Kim, MS; Fielitz, J; McAnally, J; Shelton, JM; Lemon, DD; McKinsey, TA; Richardson, JA; Bassel-Duby, R; Olson, EN,期刊:Molecular and Cellular Biology, 页码:3600-3609 , 文章类型: Article,,卷期:2008年28-11]
- Skeletal muscle consists of type I and type II myofibers, which exhibit different metabolic and contractile properties. Type I fibers display an oxidative metabolism and are resistant to fatigue, whereas type II fibers a...
- Phospholipase C gamma 2 modulates integrin signaling in the osteoclast by affecting the localization and activation of Src kinase
[作者:Epple, H; Cremasco, V; Zhang, KH; Mao, DL; Longmore, GD; Faccio, R,期刊:Molecular and Cellular Biology, 页码:3610-3622 , 文章类型: Article,,卷期:2008年28-11]
- Integrin engagement induces a cascade of signaling pathways that include tyrosine phosphorylation of numerous proteins that lead to modulation of the actin cytoskeleton. Src is a major intracellular mediator of integrin-...
- Progesterone induction of the 11 beta-hydroxysteroid dehydrogenase type 2 promoter in breast cancer cells involves coordinated recruitment of STAT5A and progesterone receptor to a distal enhancer and polymerase tracking
[作者:Subtil-Rodriguez, A; Millan-Arino, L; Quiles, I; Ballare, C; Beato, M; Jordan, A,期刊:Molecular and Cellular Biology, 页码:3830-3849 , 文章类型: Article,,卷期:2008年28-11]
- Steroid hormone receptors regulate gene expression, interacting with target DNA sequences but also activating cytoplasmic signaling pathways. Using the human 11 beta-hydroxysteroid dehydrogenase type 2 (11 beta-HSD2) gen...
- Molecular characterization of the role of the Schizosaccharomyces pombe nip1(+)/ctp1(+) gene in DNA double-strand break repair in association with the Mre11-Rad50-Nbs1 coraplex
[作者:Akamatsu, Y; Murayama, Y; Yamada, T; Nakazaki, T; Tsutsui, Y; Ohta, K; Iwasaki, H,期刊:Molecular and Cellular Biology, 页码:3639-3651 , 文章类型: Article,,卷期:2008年28-11]
- The Schizosaccharomyces pombe nip1(+)/ctp1(+) gene was previously identified as an slr (synthetically lethal with rad2) mutant. Epistasis analysis indicated that Nip1/Ctp1 functions in Rhp51-dependent recombinational rep...
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