- Synthesis of new substituted azetidinoyl and thiazolidinoyl-1,3,4-thiadiazino (6,5-b) indoles as promising anti-inflammatory agents
[作者:Bhati, SK; Kumar, A,期刊:European Journal of Medicinal Chemistry, 页码:2323-2330 , 文章类型: Article,,卷期:2008年43-11]
Various N-({5-[(arylmethylene)amino]-1,3,4-thiadiazol-2-yl}methyl) [1,3,4] thiadiazino[6,5-b]indol-3-amine (6a-6h), 2-aryl-3-{5-[{[1,3,4] thiadiazino[6,5- b]indol-3-ylamino}methyl]-1,3,4-thiadiazol-2-yl}-1,3-thiazolid...
- Synthesis and pharmacological investigation of novel 4-(2-methylphenyl)-1-substituted-4H-[1,2,4]triazolo[4,3-a]quinazolin-5-ones as new class of H-1-antihistaminic agents
[作者:Alagarsamy, V; Rupeshkumar, M; Kavitha, K; Meena, S; Shankar, D; Siddiqui, AA; Rajesh, R,期刊:European Journal of Medicinal Chemistry, 页码:2331-2337 , 文章类型: Article,,卷期:2008年43-11]
A series of novel 1-substituted-4-(2-methylphenyl)-4H-[1,2,4]triazolo[4,3-a]quinazolin-5-ones were synthesized by the cyclization of 2-hydrazino-3-(2-methylphenyl)-3H-quinazolin-4-one with various one carbon donors. T...
- Synthesis and antitumor studies on novel Co(II), Ni(II) and Cu(II) metal complexes of bis(3-acetylcoumarin)thiocarbohydrazone
[作者:Sathisha, MP; Shetti, UN; Revankar, VK; Pai, KSR,期刊:European Journal of Medicinal Chemistry, 页码:2338-2346 , 文章类型: Article,,卷期:2008年43-11]
The synthesis, structure, physico-chemical investigation and biological studies of some metal complexes of thiocarbohydrazone ligands are described. The ligand is obtained by condensation of N,N '-thiocarbohydrazide w...
- 3D and quantum QSAR of non-benzodiazepine compounds
[作者:Pasha, FA; Muddassar, M; Cho, SJ; Ahmad, K; Beg, Y,期刊:European Journal of Medicinal Chemistry, 页码:2361-2372 , 文章类型: Article,,卷期:2008年43-11]
A combined physicochemical and 3D technique is used to establish the QSAR of four series of non-benzodiazepines towards BzR. In physicochemical QSAR study, the semi-empirical PM3 based parameters like hardness, electr...
- Lanostane-type triterpenoids from the sclerotia of Inonotus obliquus possessing anti-tumor promoting activity
[作者:Taji, S; Yamada, T; Wada, S; Tokuda, H; Sakuma, K; Tanaka, R,期刊:European Journal of Medicinal Chemistry, 页码:2373-2379 , 文章类型: Article,,卷期:2008年43-11]
Two new lanostane-type triterpenoids, 1 and 2 besides two known lanostane-type triterpenoids, 3 and 4 were isolated from the sclerotia of Inonotus obliquus. Their structures were determined to be lanosta-8,23E-diene-3...
- Synthesis, spectral characterization and bio-analysis of some organotin(IV) complexes
[作者:Rehman, W; Baloch, MK; Badshah, A,期刊:European Journal of Medicinal Chemistry, 页码:2380-2385 , 文章类型: Article,,卷期:2008年43-11]
Five novel organotin(IV) derivatives have been synthesized by refluxing trimethyl, triethyl, tributyl, and triphenyl and tribenzyltin chloride with Schiff base derived from salicylaldehyde and adenine. These compounds...
- Synthesis and induction of G0-G1 phase arrest with apoptosis of 3,5-dimethyl-6-phenyl-8-(trifluoromethyl)-5,6-dihydropyrazolo[3,4-f][1,2,3,5]tetrazepin-4(3H)-one
[作者:Maggio, B; Raffa, D; Raimondi, MV; Cascioferro, S; Plescia, F; Tolomeo, M; Barbusca, E; Cannizzo, G; Mancuso, S; Daidone, G,期刊:European Journal of Medicinal Chemistry, 页码:2386-2394 , 文章类型: Article,,卷期:2008年43-11]
The multistep synthesis of 3,5-dimethyl-6-phenyl-8-(trifluoromethyl)-5,6-dihydropyrazolo [3,4-f][1,2,3,5]tetrazepin-4(3H)-one 15 has been carried out. The compound showed antiproliferative and apoptotic effects agains...
- Synthesis and aldose reductase inhibitory activity of some new chromonyl-2,4-thiazolidinediones
[作者:Bozdak-Dundar, O; Evranos, B; Das-Evcimen, N; Sarikaya, M; Ertan, R,期刊:European Journal of Medicinal Chemistry, 页码:2412-2417 , 文章类型: Article,,卷期:2008年43-11]
As it is known that still, there were no any confident ARIs on the market and they have several side effects, we need to approve new ARIs to reduce diabetic complications especially which have effect on the cataract f...
- Synthesis and testing of peptides for anti-prion activity
[作者:Sellarajah, S; Boussard, C; Lekishvili, T; Brown, DR; Gilbert, IH,期刊:European Journal of Medicinal Chemistry, 页码:2418-2427 , 文章类型: Article,,卷期:2008年43-11]
Creutzfeldt-Jakob disease (CJD) is one of the fatal transmissible spongiform encephalopathies for which there is no known cure. The disease is associated with an abnormally folded prion protein, PrP-res, which is thou...
- Synthesis, characterization of copper(II), cobalt(II), nickel(II), zinc(II) and cadmium(II) complexes of [7-hydroxy-4-methyl-8-coumarinyl]glycine and a comparitive study of their microbial activities
[作者:Gudasi, KB; Patil, MS; Vadavi, RS,期刊:European Journal of Medicinal Chemistry, 页码:2436-2441 , 文章类型: Article,,卷期:2008年43-11]
A new Mannich base, [7-hydroxy-4-methyl-8-coumarinyl]glycine [MCGH(2)], has been prepared by the condensation of 7-hydroxy-4-methyl-coumarin with glycine and formaldehyde. Its conformational changes on complexation wi...
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