- MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma
[作者：Fornari, F; Gramantieri, L; Ferracin, M; Veronese, A; Sabbioni, S; Calin, GA; Grazi, GL; Giovannini, C; Croce, CM; Bolondi, L; Negrini, M,期刊：Oncogene, 页码：5651-5661 , 文章类型： Article，,卷期：2008年27-43]
- The identification of target mRNAs is a key step for assessing the role of aberrantly expressed microRNAs in human cancer. MiR-221 is upregulated in human hepatocellular carcinoma (HCC) as well as in other malignancies. ...
- Histone H2AX is a critical factor for cellular protection against DNA alkylating agents
[作者：Meador, JA; Zhao, M; Su, Y; Narayan, G; Geard, CR; Balajee, AS,期刊：Oncogene, 页码：5662-5671 , 文章类型： Article，,卷期：2008年27-43]
- Histone H2A variant H2AX is a dose-dependent suppressor of oncogenic chromosome translocations. H2AX participates in DNA double-strand break repair, but its role in other DNA repair pathways is not known. In this study, ...
- Involvement of elevated expression of multiple cell-cycle regulator, DTL/RAMP (denticleless/RA-regulated nuclear matrix associated protein), in the growth of breast cancer cells
[作者：Ueki, T; Nishidate, T; Park, JH; Lin, ML; Shimo, A; Hirata, K; Nakamura, Y; Katagiri, T,期刊：Oncogene, 页码：5672-5683 , 文章类型： Article，,卷期：2008年27-43]
- To investigate the detailed molecular mechanism of mammary carcinogenesis and discover novel therapeutic targets, we previously analysed gene expression profiles of breast cancers. We here report characterization of a si...
- Roles of induced expression of MAPK phosphatase-2 in tumor development in RET-MEN2A transgenic mice
[作者：Hasegawa, T; Enomoto, A; Kato, T; Kawai, K; Miyamoto, R; Jijiwa, M; Ichihara, M; Ishida, M; Asai, N; Murakumo, Y; Ohara, K; Niwa, Y; Goto, H; Takahashi, M,期刊：Oncogene, 页码：5684-5695 , 文章类型： Article，,卷期：2008年27-43]
- Germline mutations in the RET tyrosine kinase gene are responsible for the development of multiple endocrine neoplasia 2A and 2B (MEN2A and MEN2B). However, knowledge of the fundamental principles that determine the muta...
- DAPK2 is a novel E2F1/KLF6 target gene involved in their proapoptotic function
[作者：Britschgi, A; Trinh, E; Rizzi, M; Jenal, M; Ress, A; Tobler, A; Fey, MF; Helin, K; Tschan, MP,期刊：Oncogene, 页码：5706-5716 , 文章类型： Article，,卷期：2008年27-43]
- Death-associated protein kinase 2 (DAPK2) belongs to a family of proapoptotic Ca2+/calmodulin-regulated serine/threonine kinases. We recently identified DAPK2 as an enhancing factor during granulocytic differentiation. T...
- p300 provides a corepressor function by cooperating with YY1 and HDAC3 to repress c-Myc
[作者：Sankar, N; Baluchamy, S; Kadeppagari, RK; Singhal, G; Weitzman, S; Thimmapaya, B,期刊：Oncogene, 页码：5717-5728 , 文章类型： Article，,卷期：2008年27-43]
- We showed earlier that p300/CBP plays an important role in G1 progression by negatively regulating c-Myc and thereby preventing premature G1 exit. Here, we have studied the mechanism by which p300 represses c-Myc and sho...
- LRIG1 negatively regulates the oncogenic EGF receptor mutant EGFRvIII
[作者：Stutz, MA; Shattuck, DL; Laederich, MB; Carraway, KL; Sweeney, C,期刊：Oncogene, 页码：5741-5752 , 文章类型： Article，,卷期：2008年27-43]
- Epidermal growth factor receptor (EGFR) mutation is frequently observed in human cancer and contributes to the growth, survival and therapeutic resistance of tumors. EGFRvIII is an oncogenic EGFR mutant resulting from th...
- Cis-acting genomic elements of the Pas1 locus control Kras mutability in lung tumors
[作者：Manenti, G; Trincucci, G; Pettinicchio, A; Amendola, E; Scarfo, M; Dragani, TA,期刊：Oncogene, 页码：5753-5758 , 文章类型： Article，,卷期：2008年27-43]
- The Pas1 locus is the major tumor modi. er of lung tumorigenesis in mouse inbred strains. Of six genes contained in a conserved haplotype, three (Casc1, Kras and Ifltd1) have been proposed as Pas1 candidates, but mechani...
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