- C-MYC overexpression is required for continuous suppression of oncogene-induced senescence in melanoma cells
[作者:Zhuang, D; Mannava, S; Grachtchouk, V; Tang, WH; Patil, S; Wawrzyniak, JA; Berman, AE; Giordano, TJ; Prochownik, EV; Soengas, MS; Nikiforov, MA,期刊:Oncogene, 页码:6623-6634 , 文章类型: Article,,卷期:2008年27-52]
- Malignant melanomas often harbor activating mutations in BRAF (V600E) or, less frequently, in NRAS (Q61R). Intriguingly, the same mutations have been detected at higher incidences in benign nevi, which are largely compos...
- Phosphorylation of Plk1 at Ser326 regulates its functions during mitotic progression
[作者:Tang, J; Yang, X; Liu, X,期刊:Oncogene, 页码:6635-6645 , 文章类型: Article,,卷期:2008年27-52]
- Polo-like kinase 1 (Plk1), the best characterized member of the mammalian polo-like kinase family, is well regulated throughout the cell cycle at the protein expression level. Moreover, it is known that Plk1 kinase activ...
- Apoptosis-based treatment of glioblastomas with ABT-737, a novel small molecule inhibitor of Bcl-2 family proteins
[作者:Tagscherer, KE; Fassl, A; Campos, B; Farhadi, M; Kraemer, A; Bock, BC; Macher-Goeppinger, S; Radlwimmer, B; Wiestler, OD; Herold-Mende, C; Roth, W,期刊:Oncogene, 页码:6646-6656 , 文章类型: Article,,卷期:2008年27-52]
- Defects in the apoptotic signaling cascades contribute to the poor therapeutic response of malignant gliomas. As glioblastomas are characterized by high expression levels of anti-apoptotic Bcl-2 family proteins, we studi...
- MicroRNA-196a targets annexin A1: a microRNA-mediated mechanism of annexin A1 downregulation in cancers
[作者:Luthra, R; Singh, RR; Luthra, MG; Li, YX; Hannah, C; Romans, AM; Barkoh, BA; Chen, SS; Ensor, J; Maru, DM; Broaddus, RR; Rashid, A; Albarracin, CT,期刊:Oncogene, 页码:6667-6678 , 文章类型: Article,,卷期:2008年27-52]
- Suppression of annexin A1 (ANXA1), a mediator of apoptosis and inhibitor of cell proliferation, is well documented in various cancers but the underlying mechanism remains unknown. We investigated whether decreased ANXA1 ...
- Overlapping gene expression profiles of cell migration and tumor invasion in human bladder cancer identify metallothionein 1E and nicotinamide N-methyltransferase as novel regulators of cell migration
[作者:Wu, Y; Siadaty, MS; Berens, ME; Hampton, GM; Theodorescu, D,期刊:Oncogene, 页码:6679-6689 , 文章类型: Article,,卷期:2008年27-52]
- Cell migration is essential to cancer invasion and metastasis and is spatially and temporally integrated through transcriptionally dependent and independent mechanisms. As cell migration is studied in vitro, it is import...
- The G1556S-type tuberin variant suppresses tumor formation in tuberous sclerosis 2 mutant (Eker) rats despite its deficiency in mTOR inhibition
[作者:Shiono, M; Kobayashi, T; Takahashi, R; Sun, G; Abe, M; Zhang, D; Wang, L; Piao, X; Takagi, Y; Mineki, R; Taka, H; Tada, N; Sonobe, S; Momose, S; Ueda, M; Hino, O,期刊:Oncogene, 页码:6690-6697 , 文章类型: Article,,卷期:2008年27-52]
- Tuberin, a tumor-suppressor protein produced by the tuberous sclerosis gene TSC2, downregulates the Rheb-mTOR-S6K pathway (mTOR axis). Comparison of the effects of human tuberin mutations, such as G1556S, suggests that p...
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