- Regulation of androgen receptor transcriptional activity by rapamycin in prostate cancer cell proliferation and survival
[作者:Wang, Y; Mikhailova, M; Bose, S; Pan, CX; White, RD; Ghosh, PM,期刊:Oncogene, 页码:7106-7117 , 文章类型: Article,,卷期:2008年27-56]
- The mTOR (mammalian target of rapamycin) inhibit or rapamycin caused growth arrest in both androgen-dependent and androgen-independent prostate cancer cells; however, long-term treatment induced resistance to the drug. T...
- Prostate tumor progression is mediated by a paracrine TGF-beta/Wnt3a signaling axis
[作者:Li, X; Placencio, V; Iturregui, JM; Uwamariya, C; Sharif-Afshar, AR; Koyama, T; Hayward, SW; Bhowmick, NA,期刊:Oncogene, 页码:7118-7130 , 文章类型: Article,,卷期:2008年27-56]
- Transforming growth factor (TGF)-beta is an important paracrine factor in tumorigenesis. Ligand binding of the type I and II TGF-beta receptors initiate downstream signaling. The role of stromal TGF-beta signaling in pro...
- CEACAM1, a SOX9 direct transcriptional target identified in the colon epithelium
[作者:Zalzali, H; Naudin, C; Bastide, P; Quittau-Prevostel, C; Yaghi, C; Poulat, F; Jay, P; Blache, P,期刊:Oncogene, 页码:7131-7138 , 文章类型: Article,,卷期:2008年27-56]
- A deletion of the transcription factor SOX9 gene in the mice intestine affects the morphology of the colon epithelium and leads to hyperplasia. Nevertheless, direct transcriptional targets of SOX9 in this tissue are stil...
- Oncogene activation in melanocytes links reactive oxygen to multinucleated phenotype and senescence
[作者:Leikam, C; Hufnagel, A; Schartl, M; Meierjohann, S,期刊:Oncogene, 页码:7070-7082 , 文章类型: Article,,卷期:2008年27-56]
- Contrary to malignant melanoma, nevi are a benign form of melanocytic hyperproliferation. They are frequently observed as precursor lesions of melanoma, but they also feature biochemical markers of senescence. In particu...
- Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer
[作者:Wolf, I; Levanon-Cohen, S; Bose, S; Ligumsky, H; Sredni, B; Kanety, H; Kuro-o, M; Karlan, B; Kaufman, B; Koeffler, HP; Rubinek, T,期刊:Oncogene, 页码:7094-7105 , 文章类型: Article,,卷期:2008年27-56]
- Klotho is an anti-aging gene, which has been shown to inhibit the insulin and insulin-like growth factor 1 (IGF-1) pathways in mice hepatocytes and myocytes. As IGF-1 and insulin regulate proliferation, survival and meta...
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