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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共12条记录   Working with the best [作者：Oskin, B,期刊：Cancer Cell, 页码：U1-U4 , 文章类型： Article，,卷期：2008年13-4] Modeling of C/EBP alpha mutant acute myeloid leukemia reveals a common expression signature of committed myeloid leukemia-initiating cells [作者：Kirstetter, P; Schuster, MB; Bereshchenko, O; Moore, S; Dvinge, H; Kurz, E; Theilgaard-Monch, K; Mansson, R; Pedersen, TA; Pabst, T; Schrock, E; Porse, BT; Jacobsen, SEW; Bertone, P; Tenen, DG; Nerlov, C,期刊：Cancer Cell, 页码：299-310 , 文章类型： Article，,卷期：2008年13-4] Mutations in the CEBPA gene are present in 7%-10% of human patients with acute myeloid leukemia (AML). However, no genetic models exist that demonstrate their etiological relevance. To mimic the most common mutations aff... Efficacy of TG101348, a selective JAK2 inhibitor, in treatment of a murine model of JAK2V617F-induced polycythemia vera [作者：Werning, G; Kharas, MG; Okabe, R; Moore, SA; Leeman, DS; Cullen, DE; Gozo, M; McDowell, EP; Levine, RL; Doukas, J; Mak, CC; Noronha, G; Martin, M; Ko, YD; Lee, BH; Soll, RM; Tefferi, A; Hood, JD; Gilliland, DG,期刊：Cancer Cell, 页码：311-320 , 文章类型： Article，,卷期：2008年13-4] We report that TG101348, a selective small-molecule inhibitor of JAK2 with an in vitro IC50 of similar to 3 nM, shows therapeutic efficacy in a murine model of myeloproliferative disease induced by the JAK2V617F mutation... Selective inhibition of JAK2-Driven erythroid differentiation of polycythemia vera progenitors [作者：Geron, I; Abrahamsson, AE; Barroga, CF; Kavalerchik, E; Gotlib, J; Hood, JD; Durocher, J; Mak, CC; Noronha, G; Soll, RM; Tefferi, A; Kaushansky, K; Jamieson, CHM,期刊：Cancer Cell, 页码：321-330 , 文章类型： Article，,卷期：2008年13-4] Polycythemia Vera (PV) is a myeloproliferative disorder (MPD) that is commonly characterized by mutant JAK2 (JAK2V617F) signaling, erythrocyte overproduction, and a propensity for thrombosis, progression to myelofibrosis... Blocking neuropilin-2 function inhibits tumor cell metastasis [作者：Caunt, M; Mak, J; Liang, WC; Stawicki, S; Pan, Q; Tong, RK; Kowalski, J; Ho, C; Reslan, HB; Ross, J; Berry, L; Kasman, I; Zlot, C; Cheng, Z; Le Couter, J; Filvaroff, EH; Plowman, G; Peale, F; French, D; Carano, R; Koch, AW; Wu, Y; Watts, RJ; Tessier-Lavigne, M; Bagri, A,期刊：Cancer Cell, 页码：331-342 , 文章类型： Article，,卷期：2008年13-4] Metastasis, which commonly uses lymphatics, accounts for much of the mortality associated with cancer. The vascular endothelial growth factor (VEGF)-C coreceptor, neuropilin-2 (Nrp2), modulates but is not necessary for d... The signaling adaptor p62 is an important NF-kappa B mediator in tumorigenesis [作者：Duran, A; Linares, JF; Galvez, AS; Wikenheiser, K; Flores, JM; Diaz-Meco, MT; Moscat, J,期刊：Cancer Cell, 页码：343-354 , 文章类型： Article，,卷期：2008年13-4] The balance between cell death and survival, two critical aspects of oncogenic transformation, determines the outcome of tumorigenesis. Nuclear factor-kappa B (NF-kappa B) is a critical regulator of survival; it is induc... Feedback circuit among INK4 tumor suppressors constrains human glioblastoma development [作者：Wiedemeyer, R; Brennan, C; Heffernan, TP; Xiao, YH; Mahoney, J; Protopopov, A; Zheng, H; Bignell, G; Furnari, F; Cavenee, WK; Hahn, WC; Ichimura, K; Collins, VP; Chu, GC; Stratton, MR; Ligon, KL; Futreal, PA; Chin, L,期刊：Cancer Cell, 页码：355-364 , 文章类型： Article，,卷期：2008年13-4] We have developed a nonheuristic genome topography scan (GTS) algorithm to characterize the patterns of genomic alterations in human glioblastoma (GBM), identifying frequent p18(INK4C) and p16(INK4A) codeletion. Function... Matuzumab binding to EGFR prevents the conformational rearrangement required for dimerization [作者：Schmiedel, J; Blaukat, A; Li, SQ; Knochel, T; Ferguson, KM,期刊：Cancer Cell, 页码：365-373 , 文章类型： Article，,卷期：2008年13-4] An increasing number of therapeutic antibodies targeting tumors that express the epidermal growth factor receptor (EGFR) are in clinical use or late stages of clinical development. Here we investigate the molecular basis... C/EBP alpha in leukemogenesis: A matter of being in the right place with the right signals [作者：Castilla, LH,期刊：Cancer Cell, 页码：289-291 , 文章类型： Editorial Material，,卷期：2008年13-4] Leukemia-initiating cells can originate from hematopoietic progenitor cells that have acquired self-renewal capacity upon transformation with leukemic fusion genes. In this issue of Cancer Cell, Kirstetter and colleagues... A molecular view of Anti-ErbB monoclonal antibody therapy [作者：Leahy, DJ,期刊：Cancer Cell, 页码：291-293 , 文章类型： Editorial Material，,卷期：2008年13-4] Abnormal activation of the epidermal growth factor receptor (EGFR) and its homolog HER2 (Neu/ErbB2) has been associated with many human cancers, and monoclonal antibodies targeting EGFR and HER2 are effective anticancer ... RanBP2: A tumor suppressor with a new twist on Topoll, SUMO, and centromeres [作者：Navarro, MS; Bachant, J,期刊：Cancer Cell, 页码：293-295 , 文章类型： Editorial Material，,卷期：2008年13-4] In vertebrate cells, the small ubiquitin-like modifier SUMO plays a poorly defined role in targeting DNA topoisomerase II (Topoll) to centromeres (CENs) during mitosis, presumably to facilitate the untangling of sister c... VHL inactivation: A new road to senescence [作者：Kim, WY; Sharpless, NE,期刊：Cancer Cell, 页码：295-297 , 文章类型： Editorial Material，,卷期：2008年13-4] Loss of the VHL tumor suppressor gene promotes cancer in several ways, including activation of the HIF transcription factors. HIF overexpression is associated with increased malignancy in many tumor types. So why is the ...