- Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia
[作者:Wei, J; Wunderlich, M; Fox, C; Alvarez, S; Cigudosa, JC; Wilhelm, JS; Zheng, Y; Cancelas, JA; Gu, Y; Jansen, M; DiMartino, JF; Mulloy, JC,期刊:Cancer Cell, 页码:483-495 , 文章类型: Article,,卷期:2008年13-6]
- Faithful modeling of mixed-lineage leukemia in murine cells has been difficult to achieve. We show that expression of MLL-AF9 in human CD34+ cells induces acute myeloid, lymphoid, or mixed-lineage leukemia in immunodefic...
- Genetic and epigenetic silencing of microRNA-203 enhances ABL1 and BCR-ABL1 oncogene expression
[作者:Bueno, MJ; de Castro, IP; de Cedron, MG; Santos, J; Calin, GA; Cigudosa, JC; Croce, CM; Fernandez-Piqueras, J; Malumbres, M,期刊:Cancer Cell, 页码:496-506 , 文章类型: Article,,卷期:2008年13-6]
- The mammalian genome contains several hundred microRNAs that regulate gene expression through modulation of target mRNAs. Here, we report a fragile chromosomal region lost in specific hematopoietic malignancies. This 7 M...
- TNFR1 signaling and IFN-gamma signaling determine whether T cells induce tumor dormancy or promote multistage carcinogenesis
[作者:Mueller-Hermelink, N; Braumuller, H; Pichler, B; Wieder, T; Mailhammer, R; Schaak, K; Ghoreschi, K; Yazdi, A; Haubner, R; Sander, CA; Mocikat, R; Schwaiger, M; Forster, I; Huss, R; Weber, WA; Kneilling, M; Rocken, M,期刊:Cancer Cell, 页码:507-518 , 文章类型: Article,,卷期:2008年13-6]
- Immune responses may arrest tumor growth by inducing tumor dormancy. The mechanisms leading to either tumor dormancy or promotion of multistage carcinogenesis by adaptive immunity are poorly characterized. Analyzing T an...
- The role of SPINK1 in ETS rearrangement-negative prostate cancers
[作者:Tomlins, SA; Rhodes, DR; Yu, JJ; Varambally, S; Mehra, R; Perner, S; Demichelis, F; Helgeson, BE; Laxman, B; Morris, DS; Cao, Q; Cao, XH; Andren, O; Fall, K; Johnson, L; Wei, JT; Shah, RB; Al-Ahmadie, H; Eastham, JA; Eggener, SE; Fine, SW; Hotakainen, K; Stenman, UH; Tsodikov, A; Gerald, WL; Lilja, H; Reuter, VE; Kantoff, PW; Scardino, PT; Rubin, MA; Bjartell, AS; Chinnaiyan, AM,期刊:Cancer Cell, 页码:519-528 , 文章类型: Article,,卷期:2008年13-6]
- ETS gene fusions have been characterized in a majority of prostate cancers; however, the key molecular alterations in ETS-negative cancers are unclear. Here we used an outlier meta-analysis (meta-COPA) to identify SPINK1...
- DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications
[作者:Jiang, X; Tan, J; Li, JS; Kivimaee, S; Yang, XJ; Zhuang, L; Lee, PL; Chan, MTW; Stanton, LW; Liu, ET; Cheyette, BNR; Yu, Q,期刊:Cancer Cell, 页码:529-541 , 文章类型: Article,,卷期:2008年13-6]
- Genetic and epigenetic defects in Wnt/beta-catenin signaling play important roles in colorectal cancer progression. Here we identify DACT3, a member of the DACT (Dpr/Frodo) gene family, as a negative regulator of Wnt/bet...
- VEGFR-3 expression is restricted to blood and lymphatic vessels in solid tumors
[作者:Petrova, TV; Bono, P; Holnthoner, W; Chesnes, J; Pytowski, B; Sihto, H; Laakkonen, P; Heikkila, P; Joensuu, H; Alitalo, K,期刊:Cancer Cell, 页码:554-556 , 文章类型: Letter,,卷期:2008年13-6]
-
- Further evidence for expression and function of the VEGF-C/VEGFR-3 axis in cancer cells
[作者:Su, JL; Chen, PS; Chien, MH; Chen, PB; Chen, YH; Lai, CC; Hung, MC; Kuo, ML,期刊:Cancer Cell, 页码:557-560 , 文章类型: Letter,,卷期:2008年13-6]
-
- Tumor cell metabolism: Cancer's Achilles' heel
[作者:Kroemer, G; Pouyssegur, J,期刊:Cancer Cell, 页码:472-482 , 文章类型: Review,,卷期:2008年13-6]
- The essential hallmarks of cancer are intertwined with an altered cancer cell-intrinsic metabolism, either as a consequence or as a cause. As an example, the resistance of cancer mitochondria against apoptosis-associated...
|