- gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis
[作者:Bollrath, J; Phesse, TJ; von Burstin, VA; Putoczki, T; Bennecke, M; Bateman, T; Nebelsiek, T; Lundgren-May, T; Canli, O; Schwitalla, S; Matthews, V; Schmid, RM; Kirchner, T; Arkan, MC; Ernst, M; Greten, FR,期刊:Cancer Cell, 页码:91-102 , 文章类型: Article,,卷期:2009年15-2]
- Although gastrointestinal cancers are frequently associated with chronic inflammation, the underlying molecular links have not been comprehensively deciphered. Using loss- and gain-of-function mice in a colitis-associate...
- Regulation of the IL-23 and IL-12 Balance by Stat3 Signaling in the Tumor Microenvironment
[作者:Kortylewski, M; Xin, H; Kujawski, M; Lee, H; Liu, Y; Harris, T; Drake, C; Pardoll, D; Yu, H,期刊:Cancer Cell, 页码:114-123 , 文章类型: Article,,卷期:2009年15-2]
- Interactions between tumor and immune cells either enhance or inhibit cancer progression. We show here that Stat3 signaling within the tumor microenvironment induces a procarcinogenic cytokine, IL-23, while inhibiting a ...
- IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer
[作者:Grivennikov, S; Karin, E; Terzic, J; Mucida, D; Yu, GY; Vallabhapurapu, S; Scheller, J; Rose-John, S; Cheroutre, H; Eckmann, L; Karin, M,期刊:Cancer Cell, 页码:103-113 , 文章类型: Article,,卷期:2009年15-2]
- Colitis-associated cancer (CAC) is the most serious complication of inflammatory bowel disease. Proinflammatory cytokines have been suggested to regulate preneoplastic growth during CAC tumorigenesis. Interleukin 6 (IL-6...
- Identification of CD15 as a Marker for Tumor-Propagating Cells in a Mouse Model of Medulloblastoma
[作者:Read, TA; Fogarty, MP; Markant, SL; McLendon, RE; Wei, ZZ; Ellison, DW; Febbo, PG; Wechsler-Reya, RJ,期刊:Cancer Cell, 页码:135-147 , 文章类型: Article,,卷期:2009年15-2]
- The growth of many cancers depends on self-renewing cells called cancer stem cells or tumor-propagating cells (TPCs). In human brain tumors, cells expressing the stem cell marker CD133 have been implicated as TPCs. Here ...
- mTOR Complex 2 Is Required for the Development of Prostate Cancer Induced by Pten Loss in Mice
[作者:Guertin, DA; Stevens, DM; Saitoh, M; Kinkel, S; Crosby, K; Sheen, JH; Mullholland, DJ; Magnuson, MA; Wu, H; Sabatini, DM,期刊:Cancer Cell, 页码:148-159 , 文章类型: Article,,卷期:2009年15-2]
- mTOR complex 2 (mTORC2) contains the mammalian target of rapamycin (mTOR) kinase and the Rictor regulatory protein and phosphorylates Akt. Whether this function of mTORC2 is critical for cancer progression is unknown. He...
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