- Swapping nucleotides, tuning Hsp70
[作者：Cyr, DM,期刊：Cell, 页码：945-947 , 文章类型： Editorial Material，,卷期：2008年133-6]
- Molecular chaperones such as heat shock protein 70 (Hsp70) are crucial for protein folding. Crystal structures of Hsp70 in a complex with the nucleotide exchange factor (NEF) Hsp110 reported in this issue of Cell (Polier...
- Rewiring bacteria, two components at a time
[作者：Kohanski, MA; Collins, JJ,期刊：Cell, 页码：947-948 , 文章类型： Editorial Material，,卷期：2008年133-6]
- In this issue, Skerker et al. (2008) present a rational method for rewiring the protein-protein interactions and output responses of prokaryotic two-component signal transduction systems. This work has important implicat...
- From ER to Eph receptors: New roles for VAP fragments
[作者：Ackerman, SL; Cox, GA,期刊：Cell, 页码：949-951 , 文章类型： Editorial Material，,卷期：2008年133-6]
- Dominantly inherited mutations in an endoplasmic reticulum protein called VAPB have been found in a subset of patients with a rare familial form of amyotrophic lateral sclerosis (ALS). In this issue, Tsuda et al. (2008) ...
- Golgi governance: The third way
[作者：Simon, SM,期刊：Cell, 页码：951-953 , 文章类型： Editorial Material，,卷期：2008年133-6]
- It is a subject of intense debate whether proteins are transported by vesicles through the membranous stacks of the Golgi or whether the stacks mature, carrying the cargo along. In this issue, Patterson et al. (2008) pre...
- The platypus genome unraveled
[作者：O'Brien, SJ,期刊：Cell, 页码：953-955 , 文章类型： Editorial Material，,卷期：2008年133-6]
- The genome of the platypus has been sequenced, assembled, and annotated by an international genomics team. Like the animal itself the platypus genome contains an amalgam of mammal, reptile, and bird-like features.
- The Amyotrophic lateral sclerosis 8 protein VAPB is cleaved, secreted, and acts as a ligand for Eph receptors
[作者：Tsuda, H; Han, SM; Yang, YF; Tong, C; Lin, YQ; Mohan, K; Haueter, C; Zoghbi, A; Harati, Y; Kwan, J; Miller, MA; Bellen, HJ,期刊：Cell, 页码：963-977 , 文章类型： Article，,卷期：2008年133-6]
- VAP proteins (human VAPB/ALS8, Drosophila VAP33, and C. elegans VPR-1) are homologous proteins with an amino-terminal major sperm protein (MSP) domain and a transmembrane domain. The MSP domain is named for its similarit...
- Centrosome amplification can initiate tumorigenesis in flies
[作者：Basto, R; Brunk, K; Vinadogrova, T; Peel, N; Franz, A; Khodjakov, A; Raff, JW,期刊：Cell, 页码：1032-1042 , 文章类型： Article，,卷期：2008年133-6]
- Centrosome amplification is a common feature of many cancer cells, and it has been previously proposed that centrosome amplification can drive genetic instability and so tumorigenesis. To test this hypothesis, we generat...
- Unexpected pieces to the senescence puzzle
[作者：Cichowski, K; Hahn, WC,期刊：Cell, 页码：958-961 , 文章类型： Review，,卷期：2008年133-6]
- Although initially described as the end state of cells after extended rounds of division in culture, it is now clear that cellular senescence induced by different stimuli plays an important role in tumor suppression in v...
- Systemic endocrine instigation of indolent tumor growth requires osteopontin
[作者：McAllister, SS; Gifford, AM; Greiner, AL; Kelleher, SP; Saelzler, MP; Ince, TA; Reinhardt, F; Harris, LN; Hylander, BL; Repasky, EA; Weinberg, RA,期刊：Cell, 页码：994-1005 , 文章类型： Article，,卷期：2008年133-6]
- The effects of primary tumors on the host systemic environment and resulting contributions of the host to tumor growth are poorly understood. Here, we find that human breast carcinomas instigate the growth of otherwise-i...
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