- Regulation of beta-Adrenergic Receptor Signaling by S-Nitrosylation of G-Protein-Coupled Receptor Kinase 2
[作者:Whalen, EJ; Foster, MW; Matsumoto, A; Ozawa, K; Violin, JD; Que, LG; Nelson, CD; Benhar, M; Keys, JR; Rockman, HA; Koch, WJ; Daaka, Y; Lefkowitz, RJ; Stamler, JS,期刊:Cell, 页码:20-30 , 文章类型: Article,,卷期:2008年135-2]
- beta-adrenergic receptors (beta-ARs), prototypic G-protein-coupled receptors (GPCRs), play a critical role in regulating numerous physiological processes. The GPCR kinases (GRKs) curtail G-protein signaling and target re...
- Morphine-Induced Receptor Endocytosis in a Novel Knockin Mouse Reduces Tolerance and Dependence
[作者:Kim, JA; Bartlett, S; He, L; Nielsen, CK; Chang, AM; Kharazia, V; Waldhoer, M; Ou, CJ; Taylor, S; Ferwerda, M; Cado, D; Whistler, JL,期刊:Cell, 页码:31-38 , 文章类型: Article,,卷期:2008年135-2]
- Opioid drugs, such as morphine, are among the most effective analgesics available. However, their utility for the treatment of chronic pain is limited by side effects including tolerance and dependence. Morphine acts pri...
- A beta-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior
[作者:Beaulieu, JM; Marion, S; Rodriguiz, RM; Medvedev, IO; Sotnikova, TD; Ghisi, V; Wetsel, WC; Lefkowitz, RJ; Gainetdinov, RR; Caron, MG,期刊:Cell, 页码:39-50 , 文章类型: Article,,卷期:2008年135-2]
- Besides their role in desensitization, beta-arrestin 1 and 2 promote the formation of signaling complexes allowing G protein-coupled receptors (GPCR) to signal independently from G proteins. Here we show that lithium, a ...
- DEP-Domain-Mediated Regulation of GPCR Signaling Responses
[作者:Ballon, DR; Flanary, PL; Gladue, DP; Konopka, JB; Dohlman, HG; Thorner, J,期刊:Cell, 页码:51-64 , 文章类型: Article,,卷期:2008年135-2]
- G protein-coupled receptors (GPCRs) mediate cellular responses to a variety of stimuli, but how specific responses are regulated has been elusive, as the types of GPCRs vastly outnumber the classes of G protein heterotri...
- Location, Location, Location ... Site-Specific GPCR Phosphorylation Offers a Mechanism for Cell-Type-Specific Signalling
[作者:Tobin, AB; Butcher, AJ; Kong, KC,期刊:Cell, 页码:5-12 , 文章类型: Article,,卷期:2008年135-2]
- It is now established that most of the similar to 800 G-protein-coupled receptors (GPCRs) are regulated by phosphorylation in a process that results in the recruitment of arrestins, leading to receptor desensitization an...
- Identification of White Adipocyte Progenitor Cells In Vivo
[作者:Rodeheffer, MS; Birsoy, K; Friedman, JM,期刊:Cell, 页码:240-249 , 文章类型: Article,,卷期:2008年135-2]
- The increased white adipose tissue (WAT) mass associated with obesity is the result of both hyperplasia and hypertrophy of adipocytes. However, the mechanisms controlling adipocyte number are unknown in part because the ...
- RTEL1 Maintains Genomic Stability by Suppressing Homologous Recombination
[作者:Barber, LJ; Youds, JL; Ward, JD; McIlwraith, MJ; O'Neil, NJ; Petalcorin, MIR; Martin, JS; Collis, SJ; Cantor, SB; Auclair, M; Tissenbaum, H; West, SC; Rose, AM; Boulton, SJ,期刊:Cell, 页码:261-271 , 文章类型: Article,,卷期:2008年135-2]
- Homologous recombination (HR) is an important conserved process for DNA repair and ensures maintenance of genome integrity. Inappropriate HR causes gross chromosomal rearrangements and tumorigenesis in mammals. In yeast,...
- Lid2 Is Required for Coordinating H3K4 and H3K9 Methylation of Heterochromatin and Euchromatin
[作者:Li, F; Huarte, M; Zaratiegui, M; Vaughn, MW; Shi, Y; Martienssen, R; Cande, WZ,期刊:Cell, 页码:272-283 , 文章类型: Article,,卷期:2008年135-2]
- In most eukaryotes, histone methylation patterns regulate chromatin architecture and function: methylation of histone H3 lysine-9 (H3K9) demarcates heterochromatin, whereas H3K4 methylation demarcates euchromatin. We sho...
- THO/Sub2p Functions to Coordinate 3 '-End Processing with Gene-Nuclear Pore Association
[作者:Rougemaille, M; Dieppois, G; Kisseleva-Romanova, E; Gudipati, RK; Lemoine, S; Blugeon, C; Boulay, J; Jensen, TH; Stutz, F; Devaux, F; Libri, D,期刊:Cell, 页码:308-321 , 文章类型: Article,,卷期:2008年135-2]
- During transcription, proteins assemble sequentially with nascent RNA to generate a messenger ribonucleoprotein particle (mRNP). The THO complex and its associated Sub2p helicase are functionally implicated in both trans...
|