- Role of N-linked oligosaccharides in the biosynthetic processing of the cystic fibrosis membrane conductance regulator
[作者:Chang, XB; Mengos, A; Hou, YX; Cui, LY; Jensen, TJ; Aleksandrov, A; Riordan, JR; Gentzsch, M,期刊:Journal of cell science, 页码:2814-2823 , 文章类型: Article,,卷期:2008年121-17]
- The epithelial chloride channel CFTR is a glycoprotein that is modified by two N-linked oligosaccharides. The most common mutant CFTR protein in patients with cystic fibrosis,Delta F508, is misfolded and retained by ER q...
- Versatile DNA damage detection by the global genome nucleotide excision repair protein XPC
[作者:Hoogstraten, D; Bergink, S; Verbiest, VHM; Luijsterburg, MS; Geverts, B; Raams, A; Dinant, C; Hoeijmakers, JHJ; Vermeulen, W; Houtsmuller, AB,期刊:Journal of cell science, 页码:2850-2859 , 文章类型: Article,,卷期:2008年121-17]
- To investigate how the nucleotide excision repair initiator XPC locates DNA damage in mammalian cell nuclei we analyzed the dynamics of GFP-tagged XPC. Photobleaching experiments showed that XPC constantly associates wit...
- btn1 affects cytokinesis and cell-wall deposition by independent mechanisms, one of which is linked to dysregulation of vacuole pH
[作者:Codlin, S; Haines, RL; Burden, JJE; Mole, SE,期刊:Journal of cell science, 页码:2860-2870 , 文章类型: Article,,卷期:2008年121-17]
- btn1, the Schizosaccharomyces pombe orthologue of the human Batten-disease gene CLN3, is involved in vacuole pH homeostasis. We show that loss of btn1 also results in a defective cell wall marked by sensitivity to zymoly...
- TRPV4 enhances the cellular uptake of aminoglycoside antibiotics
[作者:Karasawa, T; Wang, Q; Fu, Y; Cohen, DM; Steyger, PS,期刊:Journal of cell science, 页码:2871-2879 , 文章类型: Article,,卷期:2008年121-17]
- The cochlea and kidney are susceptible to aminoglycoside-induced toxicity. The non-selective cation channel TRPV4 is expressed in kidney distal tubule cells, and hair cells and the stria vascularis in the inner ear. To d...
- P-Rex1 - a multidomain protein that regulates neurite differentiation
[作者:Waters, JE; Astle, MV; Ooms, LM; Balamatsias, D; Gurung, R; Mitchell, CA,期刊:Journal of cell science, 页码:2892-2903 , 文章类型: Article,,卷期:2008年121-17]
- The Rac-GEF P-Rex1 promotes membrane ruffling and cell migration in response to Rac activation, but its role in neuritogenesis is unknown. Rac1 promotes neurite differentiation; Rac3, however, may play an opposing role. ...
- Accelerated re-epithelialization in Dpr2-deficient mice is associated with enhanced response to TGF beta signaling
[作者:Meng, FW; Cheng, X; Yang, LL; Hou, N; Yang, X; Meng, AM,期刊:Journal of cell science, 页码:2904-2912 , 文章类型: Article,,卷期:2008年121-17]
- Members of the Dapper (Dpr)/Dact protein family are involved in the regulation of distinct signaling pathways, including TGF beta/Nodal, canonical and noncanonical Wnt pathways. Three Dpr genes, Dpr1, Dpr2 and Dpr3, are ...
- Mitochondrial shuttling of CAP1 promotes actin- and cofilin-dependent apoptosis
[作者:Wang, CH; Zhou, GL; Vedantam, S; Li, P; Field, J,期刊:Journal of cell science, 页码:2913-2920 , 文章类型: Article,,卷期:2008年121-17]
- Mitochondria play a central role in regulating apoptosis by releasing proapoptotic contents such as cytochrome c, and generating reactive oxygen species (ROS). Early in apoptosis, proteins translocate to mitochondria to ...
- Multiple functions encoded by the N-terminal PAT domain of adipophilin
[作者:Orlicky, DJ; DeGala, G; Greenwood, C; Bales, ES; Russell, TD; McManaman, JL,期刊:Journal of cell science, 页码:2921-2929 , 文章类型: Article,,卷期:2008年121-17]
- Adipophilin (ADPH), a member of the perilipin family of cytoplasmic lipid droplet (CLD)-binding proteins, is crucially dependent on triglyceride synthesis for stability. We have used cell lines expressing full-length or ...
- Arginine deiminase has multiple regulatory roles in the biology of Giardia lamblia
[作者:Touz, MC; Ropolo, AS; Rivero, MR; Vranych, CV; Conrad, JT; Svard, SG; Nash, TE,期刊:Journal of cell science, 页码:2930-2938 , 文章类型: Article,,卷期:2008年121-17]
- The protozoan parasite Giardia lamblia uses arginine deiminase (ADI) to produce energy from free L-arginine under anaerobic conditions. In this work, we demonstrate that, in addition to its known role as a metabolic enzy...
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