- Mesenchymal stem cells: Revisiting history, concepts, and assays
[作者:Bianco, P; Robey, PG; Simmons, PJ,期刊:Cell Stem Cell, 页码:313-319 , 文章类型: Article,,卷期:2008年2-4]
- The concept of mesenchymal stem cells has gained wide popularity. Despite the rapid growth of the field, uncertainties remain with respect to the defining characteristics of these cells, including their potency and self-...
- Module map of stem cell genes guides creation of epithelial cancer stem cells
[作者:Wong, DJ; Liu, H; Ridky, TW; Cassarino, D; Segal, E; Chang, HY,期刊:Cell Stem Cell, 页码:333-344 , 文章类型: Article,,卷期:2008年2-4]
- Self-renewal is a hallmark of stem cells and cancer, but existence of a shared sternness program remains controversial. Here, we construct a gene module map to systematically relate transcriptional programs in embryonic ...
- Trophoblast differentiation defect in human embryonic stem cells lacking PIG-A and GPI-anchored cell-surface proteins
[作者:Chen, GB; Ye, ZH; Yu, XB; Zou, JH; Mali, P; Brodsky, RA; Cheng, LZ,期刊:Cell Stem Cell, 页码:345-355 , 文章类型: Article,,卷期:2008年2-4]
- Pluripotent human embryonic stem (hES) cells can differentiate into various cell types derived from the three embryonic germ layers and extraembryonic tissues such as trophoblasts. The mechanisms governing lineage choice...
- Canonical notch signaling is dispensable for the maintenance of adult hematopoietic stem cells
[作者:Maillard, I; Koch, U; Dumortier, A; Shestova, O; Xu, L; Sai, H; Pross, SE; Aster, JC; Bhandoola, A; Radtke, F; Pear, WS,期刊:Cell Stem Cell, 页码:356-366 , 文章类型: Article,,卷期:2008年2-4]
- Gain-of-function experiments have demonstrated the potential of Notch signals to expand primitive hematopoietic progenitors, but whether Notch physiologically regulates hematopoietic stem cell (HSC) homeostasis in vivo i...
- N-cadherin expression level distinguishes reserved versus primed states of hematopoietic stem cells
[作者:Haug, JS; He, XC; Grindley, JC; Wunderlich, JP; Gaudenz, K; Ross, JT; Paulson, A; Wagner, KP; Xie, YC; Zhu, RH; Yin, T; Perry, JM; Hembree, MJ; Redenbaugh, EP; Radice, GL; Seidel, C; Li, LH,期刊:Cell Stem Cell, 页码:367-379 , 文章类型: Article,,卷期:2008年2-4]
- Osteoblasts expressing the homophilic adhesion molecule N-cadherin form a hematopoietic stem cell (HSC) niche. Therefore, we examined how N-cadherin expression in HSCs relates to their function. We found that bone marrow...
- The transcription factor EGR1 controls both the proliferation and localization of hematopoietic stem cells
[作者:Min, IM; Pietramaggiori, G; Kim, FS; Passegue, E; Stevenson, KE; Wagers, AJ,期刊:Cell Stem Cell, 页码:380-391 , 文章类型: Article,,卷期:2008年2-4]
- EGR1 is a member of the immediate early response transcription factor family and functions in cell growth, development, and stress responses in many tissues. Here we report an additional role for EGR1 in regulating homeo...
- Ontogeny and multipotency of neural crest-derived stem cells in mouse bone marrow, dorsal root ganglia, and whisker pad
[作者:Nagoshi, N; Shibata, S; Kubota, Y; Nakarnura, M; Nagai, Y; Satoh, E; Morikawa, S; Okada, Y; Mabuchi, Y; Katoh, H; Okada, S; Fukuda, K; Suda, T; Matsuzaki, Y; Toyama, Y; Okano, H,期刊:Cell Stem Cell, 页码:392-403 , 文章类型: Article,,卷期:2008年2-4]
- Although recent reports have described multipotent, self-renewing, neural crest-derived stem cells (NCSCs), the NCSCs in various adult rodent tissues have not been well characterized or compared. Here we identified NCSCs...
- Notch in the niche
[作者:Gering, M; Patient, R,期刊:Cell Stem Cell, 页码:293-294 , 文章类型: Editorial Material,,卷期:2008年2-4]
- Notch signaling is essential for hematopoietic stem cell (HSC) formation during embryogenesis, and hitherto it was also thought to be required for HSC maintenance. However, in this issue of Cell Stem Cell, Maillard et al...
- Illuminating the black box of reprogramming
[作者:Sridharan, R; Plath, K,期刊:Cell Stem Cell, 页码:295-297 , 文章类型: Editorial Material,,卷期:2008年2-4]
- Yamanaka and colleagues, in a Science article currently published online, have generated induced pluripotent stem (iPS) cells from liver and stomach cells, suggesting that transcription factor-induced reprogramming is no...
- Building better beta cells
[作者:Stanley, EG; Elefanty, AG,期刊:Cell Stem Cell, 页码:300-301 , 文章类型: Editorial Material,,卷期:2008年2-4]
- Type 1 diabetes represents an attractive target for human embryonic stem cell (hESC)-based cell replacement therapies. Recently, in Nature Biotechnology, Kroon et al. (2008) reported encouraging progress toward this goal...
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