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  • N-cadherin expression level distinguishes reserved versus primed states of hematopoietic stem cells
    [作者:Haug, JS; He, XC; Grindley, JC; Wunderlich, JP; Gaudenz, K; Ross, JT; Paulson, A; Wagner, KP; Xie, YC; Zhu, RH; Yin, T; Perry, JM; Hembree, MJ; Redenbaugh, EP; Radice, GL; Seidel, C; Li, LH,期刊:Cell Stem Cell, 页码:367-379 , 文章类型: Article,,卷期:2008年2-4]
  • Osteoblasts expressing the homophilic adhesion molecule N-cadherin form a hematopoietic stem cell (HSC) niche. Therefore, we examined how N-cadherin expression in HSCs relates to their function. We found that bone marrow...
  • Notch in the niche
    [作者:Gering, M; Patient, R,期刊:Cell Stem Cell, 页码:293-294 , 文章类型: Editorial Material,,卷期:2008年2-4]
  • Notch signaling is essential for hematopoietic stem cell (HSC) formation during embryogenesis, and hitherto it was also thought to be required for HSC maintenance. However, in this issue of Cell Stem Cell, Maillard et al...
  • Illuminating the black box of reprogramming
    [作者:Sridharan, R; Plath, K,期刊:Cell Stem Cell, 页码:295-297 , 文章类型: Editorial Material,,卷期:2008年2-4]
  • Yamanaka and colleagues, in a Science article currently published online, have generated induced pluripotent stem (iPS) cells from liver and stomach cells, suggesting that transcription factor-induced reprogramming is no...
  • Cancer: Inappropriate expression of stem cell programs?
    [作者:Wang, Y; Armstrong, SA,期刊:Cell Stem Cell, 页码:297-299 , 文章类型: Editorial Material,,卷期:2008年2-4]
  • Cancer stem cells (CSCs) are a subpopulation of cancer cells that possess characteristics, including self-renewal, associated with normal stem cells. In this issue of Cell Stem Cell, Wong et al. (2008) define a core embr...
  • Building better beta cells
    [作者:Stanley, EG; Elefanty, AG,期刊:Cell Stem Cell, 页码:300-301 , 文章类型: Editorial Material,,卷期:2008年2-4]
  • Type 1 diabetes represents an attractive target for human embryonic stem cell (hESC)-based cell replacement therapies. Recently, in Nature Biotechnology, Kroon et al. (2008) reported encouraging progress toward this goal...
  • Hematopoietic stem cells in transit - Where's the niche?
    [作者:Magnusson, M; Mikkola, HKA,期刊:Cell Stem Cell, 页码:302-304 , 文章类型: Editorial Material,,卷期:2008年2-4]
  • In this issue of Cell Stem Cell, Min et al. (2008) identify Egr1 as a novel hematopoietic stem cell (HSC) transcription factor that regulates proliferation and mobilization of these cells. An improved understanding of Eg...