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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共60条记录   Androgens transduce the G alpha s-mediated activation of protein kinase A in prostate cells [作者：Bagchi, G; Wu, JJ; French, J; Kim, J; Moniri, NH; Daaka, Y,期刊：Cancer research, 页码：3225-3231 , 文章类型： Article，,卷期：2008年68-9] Androgens regulate the development and function of male reproductive organs and play a crucial role in the onset and progression of prostate cancer. Androgen action is primarily mediated through the nuclear androgen rece... MDM2 regulates dihydrofolate reductase activity through monoubiquitination [作者：Maguire, M; Nield, PC; Devling, T; Jenkins, RE; Park, BK; Polanski, R; Vlatkovic, N; Boyd, MT,期刊：Cancer research, 页码：3232-3242 , 文章类型： Article，,卷期：2008年68-9] MDM2 is a ubiquitin ligase that is best known for its essential function in the negative regulation of p53. In addition, MDM2 expression is associated with tumor progression in a number of common cancers, and in some cas... Cancer stem cells contribute to cisplatin resistance in Brca1/p53-mediated mouse mammary tumors [作者：Shafee, N; Smith, CR; Wei, SZ; Kim, Y; Mills, GB; Hortobagyi, GN; Stanbridge, EJ; Lee, EYHP,期刊：Cancer research, 页码：3243-3250 , 文章类型： Article，,卷期：2008年68-9] The majority of BRCA1-associated breast cancers are basal cell-like, which is associated with a poor outcome. Using a spontaneous mouse mammary tumor model, we show that platinum compounds, which generate DNA breaks duri... Two unique novel prostate-specific and androgen-regulated fusion partners of ETV4 in prostate cancer. [作者：Hermans, KG; Bressers, AA; van der Korput, HA; Dits, NF; Jenster, G; Trapman, J,期刊：Cancer research, 页码：3094-3098 , 文章类型： Article，,卷期：2008年68-9] Recently, fusion of ERG to the androgen-regulated, prostate-specific TMPRSS2 gene has been identified as the most frequent genetic alteration in prostate cancer. At low frequency, TMPRSS2-ETV1 and TMPRSS2-ETV4 fusion gen... Potential use of quantitative tissue phenotype to predict malignant risk for oral premalignant lesions [作者：Guillaud, M; Zhang, LW; Poh, C; Rosin, MP; MacAulay, C,期刊：Cancer research, 页码：3099-3107 , 文章类型： Article，,卷期：2008年68-9] The importance of early diagnosis in improving mortality and morbidity rates of oral squamous cell carcinoma (SCC) has long been recognized. However, a major challenge for early diagnosis is our limited ability to differ... Subtypes of breast cancer show preferential site of relapse [作者：Smid, M; Wang, YX; Zhang, Y; Sieuwerts, AM; Yu, J; Klijn, JGM; Foekens, JA; Martens, JWM,期刊：Cancer research, 页码：3108-3114 , 文章类型： Article，,卷期：2008年68-9] We explored whether the five previously reported molecular subtypes in breast cancer show a preference for organ-specific relapse and searched for molecular pathways involved. The "intrinsic" gene list describing the sub... Amplification of telomerase reverse transcriptase gene in human mammary epithelial cells with limiting telomerase RNA expression levels [作者：Cao, Y; Huschtscha, LI; Nouwens, AS; Pickett, HA; Neumann, AA; Chang, ACM; Toouli, CD; Bryan, TM; Reddel, RR,期刊：Cancer research, 页码：3115-3123 , 文章类型： Article，,卷期：2008年68-9] Activation of telomerase is a crucial step during cellular immortalization, and in some tumors this results from amplification of the human telomerase reverse transcriptase (hTERT) gene. Immortalization of normal human c... Microphthalmia-associated transcription factor is a critical transcriptional regulator of melanoma inhibitor of apoptosis in melanomas [作者：Dynek, JN; Chan, SM; Liu, JF; Zha, JP; Fairbrother, WJ; Vucic, D,期刊：Cancer research, 页码：3124-3132 , 文章类型： Article，,卷期：2008年68-9] Melanoma inhibitor of apoptosis (ML-IAP) is a potent inhibitor of apoptosis, which is highly expressed in melanomas and likely contributes to their resistance to chemotherapeutic treatments. Herein, we show that the line... Protein kinase A effects of an expressed PRKAR1A mutation associated with aggressive tumors [作者：Meoli, E; Bossis, I; Cazabat, L; Mavrakis, M; Horvath, A; Stergiopoulos, S; Shiferaw, ML; Fumey, G; Perlemoine, K; Muchow, M; Robinson-White, A; Weinberg, F; Nesterova, M; Patronas, Y; Groussin, L; Bertherat, J; Stratakis, CA,期刊：Cancer research, 页码：3133-3141 , 文章类型： Article，,卷期：2008年68-9] Most PRKAR1A tumorigenic mutations lead to nonsense mRNA that is decayed; tumor formation has been associated with an increase in type II protein kinase A (PKA) subunits. The IVS6+1G>T PRKAR1A mutation leads to a protein... Epigenetic modification of CCAAT/enhancer binding protein alpha expression in acute myeloid leukemia [作者：Hackanson, B; Bennett, KL; Brena, RM; Jiang, JM; Claus, R; Chen, SS; Blagitko-Dorfs, N; Maharry, K; Whitman, SP; Schmiittgen, TD; Lubbert, M; Marcucci, G; Bloomfield, CD; Plass, C,期刊：Cancer research, 页码：3142-3151 , 文章类型： Article，,卷期：2008年68-9] Functional loss of CCAAT/enhancer binding protein alpha (C/ EBP alpha), a master regulatory transcription factor in the hematopoietic system, can result in a differentiation block in granulopoiesis and thus contribute to... Transforming growth factor beta induces apoptosis through repressing the phosphoinositide 3-kinase/AKT/survivin pathway in colon cancer cells [作者：Wang, J; Yang, LM; Yang, JH; Kuropatwinski, K; Wang, W; Liu, XQ; Hauser, J; Brattain, MG,期刊：Cancer research, 页码：3152-3160 , 文章类型： Article，,卷期：2008年68-9] FET cells, derived from an early-stage colon carcinoma, are nontumorigenic in athymic mice. Stable transfection of a dominant-negative transforming growth factor beta (TGF beta) type II receptor (DNRII) into FET cells th... Genetic variants contributing to daunorubicin-induced cytotoxicity [作者：Huang, RS; Duan, SW; Kistner, EO; Bleibel, WK; Delaney, SM; Fackenthal, DL; Das, S; Dolan, ME,期刊：Cancer research, 页码：3161-3168 , 文章类型： Article，,卷期：2008年68-9] Identifying heritable genetic variants responsible for chemotherapeutic toxicities has been challenging due in part to its multigenic nature. To date, there is a paucity of data on genetic variants associated with patien... Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair [作者：Chen, X; Zhong, SJ; Zhu, Y; Dziegielewska, B; Ellenberger, T; Wilson, GM; MacKerell, AD; Tomkinson, AE,期刊：Cancer research, 页码：3169-3177 , 文章类型： Article，,卷期：2008年68-9] Based on the crystal structure of human DNA ligase I complexed with nicked DNA, computer-aided drug design was used to identify compounds in a database of 1.5 million commercially available low molecular weight chemicals... Variants of the adiponectin and adiponectin receptor 1 genes and breast cancer risk [作者：Kaklamani, VG; Sadim, M; Hsi, A; Offit, K; Oddoux, C; Ostrer, H; Ahsan, H; Pasche, B; Mantzoros, C,期刊：Cancer research, 页码：3178-3184 , 文章类型： Article，,卷期：2008年68-9] Breast cancer risk is higher among obese women and women,with diabetes. Adiponectin is a protein exclusively secreted by adipose tissue, circulating levels of which have been associated with breast cancer risk. Whether g... Fibronectin expression modulates mammary epithelial cell proliferation during acinar differentiation [作者：Williams, CM; Engler, AJ; Slone, RD; Galante, LL; Schwarzbauer, JE,期刊：Cancer research, 页码：3185-3192 , 文章类型： Article，,卷期：2008年68-9] The mammary gland consists of a polarized epithelium surrounded by a basement membrane matrix that forms a series of branching ducts ending in hollow, sphere-like acini. Essential roles for the epithelial basement membra... Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence [作者：Kumamoto, K; Spillare, EA; Fujita, K; Horikawa, I; Yamashita, T; Appella, E; Nagashima, M; Takenoshita, S; Yokota, J; Harris, CC,期刊：Cancer research, 页码：3193-3203 , 文章类型： Article，,卷期：2008年68-9] Nutlin-3, an MDM2 inhibitor, activates p53, resulting in several types of cancer cells undergoing apoptosis. Although p53 is mutated or deleted in similar to 50%o of all cancers, p53 is still functionally active in the o...