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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共63条记录   microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma [作者：Kefas, B; Godlewski, J; Comeau, L; Li, YQ; Abounader, R; Hawkinson, M; Lee, JW; Fine, H; Chiocca, EA; Lawler, S; Purow, B,期刊：Cancer research, 页码：3566-3572 , 文章类型： Article，,卷期：2008年68-10] microRNAs are noncoding RNAs inhibiting expression of numerous target genes, and a few have been shown to act as oncogenes or tumor suppressors. We show that microRNA-7 (miR-7) is a potential tumor suppressor in glioblas... Constitutive activation of signal transducers and activators of transcription predicts vorinostat resistance in cutaneous T-cell lymphoma [作者：Fantin, VR; Loboda, A; Paweletz, CP; Hendrickson, RC; Pierce, JW; Roth, JA; Li, LX; Gooden, F; Korenchuk, S; Hou, XLS; Harrington, EA; Randolph, S; Reilly, JF; Ware, CM; Kadin, ME; Frankel, SR; Richon, VM,期刊：Cancer research, 页码：3785-3794 , 文章类型： Article，,卷期：2008年68-10] Vorinostat is a histone deacetylase inhibitor that induces differentiation, growth arrest, and/or apoptosis of malignant cells both in vitro and in vivo and has shown clinical responses in similar to 30% of patients with... Cancer cell death enhances the penetration and efficacy of oncolytic herpes simplex virus in tumors [作者：Nagano, S; Perentes, JY; Jain, RK; Boucher, Y,期刊：Cancer research, 页码：3795-3802 , 文章类型： Article，,卷期：2008年68-10] The success of tumor oncolytic virotherapy is limited by the poor penetration of virus in tumors. Interstitial collagen fibers and the narrow spacing between cancer cells are major barriers hindering the movement of larg... Inhibition of N-linked glycosylation disrupts receptor tyrosine kinase signaling in tumor cells [作者：Contessa, JN; Bhojani, MS; Freeze, HH; Rehemtulla, A; Lawrence, TS,期刊：Cancer research, 页码：3803-3809 , 文章类型： Article，,卷期：2008年68-10] Receptor tyrosine kinases (RTK) are therapeutic targets for the treatment of malignancy. However, tumor cells develop resistance to targeted therapies through the activation of parallel signaling cascades. Recent evidenc... A small molecule disruptor of Rb/Raf-1 interaction inhibits cell proliferation, angiogenesis, and growth of human tumor xenografts in nude mice [作者：Kinkade, R; Dasgupta, P; Carie, A; Pernazza, D; Carless, M; Pillai, S; Lawrence, N; Sebti, SM; Chellappan, S,期刊：Cancer research, 页码：3810-3818 , 文章类型： Article，,卷期：2008年68-10] Although it is well established that cyclin-dependent kinases phosphorylate and inactivate Rb, the Raf-1 kinase physically interacts with Rb and initiates the phosphorylation cascade early in the cell cycle. We have iden... Genetic ablation of M-3 muscarinic receptors attenuates murine colon epithelial cell proliferation and neoplasia [作者：Raufman, JP; Samimi, R; Shah, N; Khurana, S; Shant, J; Drachenberg, C; Xie, GF; Wess, J; Cheng, KR,期刊：Cancer research, 页码：3573-3578 , 文章类型： Article，,卷期：2008年68-10] Colon epithelial cells express and most colon cancers overexpress M-3 muscarinic receptors (M3R). In human colon cancer cells, post-M3R signaling stimulates proliferation. To explore the importance of M3R expression in v... Inactivation of gadd45a sensitizes epithelial cancer cells to ionizing radiation in vivo resulting in prolonged survival [作者：Lu, XD; Yang, CY; Hill, R; Yin, CY; Hollander, MC; Fornace, AJ; Van Dyke, T,期刊：Cancer research, 页码：3579-3583 , 文章类型： Article，,卷期：2008年68-10] Ionizing radiation (IR) therapy is one of the most commonly used treatments for cancer patients. The responses of tumor cells to IR are often tissue specific and depend on pathway aberrations present in the tumor. Identi... Characterization of TMPRSS2-ETS gene aberrations in androgen-independent metastatic prostate cancer [作者：Mehra, R; Tomlins, SA; Yu, JJ; Cao, XH; Wang, L; Menon, A; Rubin, MA; Pienta, KJ; Shah, RB; Chinnaiyan, AM,期刊：Cancer research, 页码：3584-3590 , 文章类型： Article，,卷期：2008年68-10] Recurrent gene fusions between the androgen-regulated gene TMPRSS2 and the ETS transcription factor family members ERG, ETV1, and ETV4 have been identified as a critical event in prostate cancer development. In this stud... The Spy1/RINGO family represents a novel mechanism regulating mammary growth and tumorigenesis [作者：Golipour, A; Myers, D; Seagroves, T; Murphy, D; Evan, GI; Donoghue, DJ; Moorehead, RA; Porter, LA,期刊：Cancer research, 页码：3591-3600 , 文章类型： Article，,卷期：2008年68-10] Spy1A is a unique cell cycle activator known to mediate cell cycle progression and override the DNA damage response. This study focused on determining the role of this protein on postnatal mammary gland morphogenesis and... Down-regulation of p57(Kip2) induces prostate cancer in the mouse [作者：Jin, RJ; Lho, Y; Wang, YQ; Ao, MF; Revelo, MP; Hayward, SW; Wills, ML; Logan, SK; Zhang, P; Matusik, RJ,期刊：Cancer research, 页码：3601-3608 , 文章类型： Article，,卷期：2008年68-10] p57(Kip2) has been considered a candidate tumor suppressor gene because of its location in the genome, biochemical activities, and imprinting status. However, little is known about the role of p57(Kip2) in tumorigenesis ... Inflammatory signaling and aryl hydrocarbon receptor mediate synergistic induction of interleukin 6 in MCF-7 cells [作者：Hollingshead, BD; Beischlag, TV; DiNatale, BC; Ramadoss, P; Perdew, GH,期刊：Cancer research, 页码：3609-3617 , 文章类型： Article，,卷期：2008年68-10] The pleiotropic cytokine interleukin 6 (IL-6) is involved in immune cell homeostasis. Additionally, IL-6 expression and signaling in tumor cells have been shown to elicit both protumor and antitumor properties. There is ... Breast cancer survival is associated with telomere length in peripheral blood cells [作者：Svenson, U; Nordfjall, K; Stegmayr, B; Manjer, J; Nilsson, P; Tavelin, B; Henriksson, R; Lenner, P; Roos, G,期刊：Cancer research, 页码：3618-3623 , 文章类型： Article，,卷期：2008年68-10] Telomeres are essential for maintaining chromosomal stability. Previous studies have indicated that individuals with shorter blood telomeres may be at higher risk of developing various types of cancer, such as in lung, b... Myc-mediated transcriptional repression by recruitment of histone deacetylase [作者：Kurland, JF; Tansey, WP,期刊：Cancer research, 页码：3624-3629 , 文章类型： Article，,卷期：2008年68-10] Myc is a transcription factor that features prominently in cancer. The oncogenicity of Myc stems from its ability to regulate expression of genes required for cell growth and proliferation. Although the mechanisms throug... Single-molecule PCR analysis of germ line mutation induction by anticancer drugs in mice [作者：Glen, CD; Smith, AG; Dubrova, YE,期刊：Cancer research, 页码：3630-3636 , 文章类型： Article，,卷期：2008年68-10] Understanding and estimating the genetic hazards of exposure to chemical mutagens and anticancer drugs in humans requires the development of efficient systems for monitoring germ line mutation. The suitability of a singl... Hoxb7 inhibits transgenic HER-2/neu-induced mouse mammary tumor onset but promotes progression and lung metastasis [作者：Chen, HX; Lee, JS; Liang, XH; Zhang, HP; Zhu, T; Zhang, Z; Taylor, ME; Zahnow, C; Feigenbaum, L; Rein, A; Sukumar, S,期刊：Cancer research, 页码：3637-3644 , 文章类型： Article，,卷期：2008年68-10] Our previous studies have shown that HOXB7 mRNA is overexpressed in similar to 50% of invasive breast carcinomas and promotes tumor progression in breast cancer cells grown as xenografts in mice. In silico analysis of pu... Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways [作者：Onder, TT; Gupta, PB; Mani, SA; Yang, J; Lander, ES; Weinberg, RA,期刊：Cancer research, 页码：3645-3654 , 文章类型： Article，,卷期：2008年68-10] Loss of the epithelial adhesion molecule E-cadherin is thought to enable metastasis by disrupting intercellular contacts-an early step in metastatic dissemination. To further investigate the molecular basis of this notio...