- Molecular signature of MT1-MMP: Transactivation of the downstream universal gene network in cancer
[作者：Rozanov, DV; Savinov, AY; Williams, R; Liu, K; Golubkov, VS; Krajewski, S; Strongin, AY,期刊：Cancer research, 页码：4086-4096 , 文章类型： Article，,卷期：2008年68-11]
- Invasion-promoting MT1-NMP is directly linked to tumorigenesis and metastasis. Our studies led us to identify those genes, the expression of which is universally linked to MT1-MMP in multiple tumor types. Genome-wide exp...
- Novel role of thromboxane receptors beta isoform in bladder cancer pathogenesis
[作者：Moussa, O; Ashton, AW; Fraig, M; Garrett-Mayer, E; Ghoneim, MA; Halushka, PV; Watson, DK,期刊：Cancer research, 页码：4097-4104 , 文章类型： Article，,卷期：2008年68-11]
- These studies were undertaken to determine the potential role of thromboxane receptors (TP) in bladder cancer. The data reported herein show that expression of the TP-beta receptor protein is increased in tissue obtained...
- The E2F3-Oncomir-1 axis is activated in Wilms' tumor
[作者：Kort, EJ; Farber, L; Tretiakova, M; Petillo, D; Furge, KA; Yang, XMJ; Cornelius, A; Teh, BT,期刊：Cancer research, 页码：4034-4038 , 文章类型： Article，,卷期：2008年68-11]
- Oncomir-1 is an oncogenic cluster of microRNAs (miRNA) located on chromosome 13. Previous in vitro studies showed that it is transcriptionally regulated by the transcription factor E2F3. In this report, we combine expres...
- Laforin confers cancer resistance to energy deprivation-induced apoptosis
[作者：Wang, Y; Liu, Y; Wu, C; McNally, B; Liu, Y; Zheng, P,期刊：Cancer research, 页码：4039-4044 , 文章类型： Article，,卷期：2008年68-11]
- A long-standing but poorly understood observation in experimental cancer therapy is the heterogeneity in cancer susceptibility to energy deprivation. Here, we show that the hexose kinase inhibitor 2-deoxyglucose (2-dG) p...
- Paired toll-like receptor agonists enhance vaccine therapy through induction of interleukin-12
[作者：Zheng, RX; Cohen, PA; Paustian, CA; Johnson, TD; Lee, WT; Shu, SY; Koski, GK,期刊：Cancer research, 页码：4045-4049 , 文章类型： Article，,卷期：2008年68-11]
- Minimal requirements for generating effective immunity include the delivery of antigenic (signal 1) and costimulatory (signal 2) signals to T lymphocytes. Recently, a class of third signals, often delivered by antigen-pr...
- The roles of human sucrose nonfermenting protein 2 homologue in the tumor-promoting functions of Rsf-1
[作者：Shen, JJC; Choi, JH; Yildiz, I; Tsai, FJ; Shaul, Y; Wang, TL; Shih, IM,期刊：Cancer research, 页码：4050-4057 , 文章类型： Article，,卷期：2008年68-11]
- Rsf-1 interacts with human sucrose nonfermenting protein 2 homologue (hSNF2H) to form a chromatin remodeling complex that participates in several biological processes. We have previously shown that Rsf-1 gene amplificati...
- Cells silenced for SDHB expression display characteristic features of the tumor phenotype
[作者：Cervera, AM; Apostolova, N; Crespo, FL; Mata, M; McCreath, KJ,期刊：Cancer research, 页码：4058-4067 , 文章类型： Article，,卷期：2008年68-11]
- Recently, enzymes of the tricarboxylic acid (TCA) cycle have emerged as novel tumor suppressors. In particular, mutations in the nuclear-encoded subunits of succinate dehydrogenase (SDHB, SDHC, and SDHD) cause paragangli...
- Retinoblastoma function is essential for establishing lung epithelial quiescence after injury
[作者：Mason-Richie, NA; Mistry, MJ; Gettler, CA; Elayyadi, A; Wikenheiser-Brokamp, KA,期刊：Cancer research, 页码：4068-4076 , 文章类型： Article，,卷期：2008年68-11]
- The retinoblastoma gene product (RB) regulates cell cycle, quiescence, and survival in a cell type-dependent and environment-dependent manner. RB function is critical in the pulmonary epithelium, as evidenced by nearly u...
- Polo-like kinase 3 functions as a tumor suppressor and is a negative regulator of hypoxia-inducible factor-1 alpha under hypoxic conditions
[作者：Yang, YL; Bai, JX; Shen, RL; Brown, SAN; Komissarova, E; Huang, Y; Jiang, N; Alberts, GF; Costa, M; Lu, L; Winldes, JA; Dai, W,期刊：Cancer research, 页码：4077-4085 , 文章类型： Article，,卷期：2008年68-11]
- Polo-like kinase 3 (Plk3) is an important mediator of the cellular responses to genotoxic stresses. In this study, we examined the physiologic function of Plk3 by generating Plk3-deficient mice. Plk3(-/-) mice displayed ...
- Wnt/beta-catenin signaling contributes to activation of normal and tumorigenic liver progenitor cells
[作者：Yang, W; Yan, HX; Chen, L; Liu, Q; He, YQ; Yu, LX; Zhang, SH; Huang, DD; Tang, L; Kong, XN; Chen, C; Liu, SQ; Wu, MC; Wang, HY,期刊：Cancer research, 页码：4287-4295 , 文章类型： Article，,卷期：2008年68-11]
- Adult hepatic progenitor (oval) cells are facultative stem cells in liver, which participate in a range of human liver diseases, including hepatocellular carcinoma (HCC). However, the molecular pathways regulating the ex...
- Twist is required for thrombin-induced tumor angiogenesis and growth
[作者：Hu, L; Roth, JM; Brooks, P; Ibrahim, S; Karpatkin, S,期刊：Cancer research, 页码：4296-4302 , 文章类型： Article，,卷期：2008年68-11]
- Twist, a master regulator of embryonic morphogenesis, induces functions that are also required for tumor invasion and metastasis. Because thrombin contributes to the malignant phenotype by up-regulating tumor metastasis,...
- Histone deacetylase inhibitors reverse SS18-SSX-mediated polycomb silencing of the tumor suppressor early growth response 1 in synovial sarcoma
[作者：Lubieniecka, JM; de Bruijn, DRH; Su, L; van Dijk, AHA; Subramanian, S; van de Rijn, M; Poulin, N; van Kessel, AG; Nielsen, TO,期刊：Cancer research, 页码：4303-4310 , 文章类型： Article，,卷期：2008年68-11]
- Synovial sarcoma is a soft tissue malignancy characterized by the fusion of SS18 to either SSX1, SSX2, or SSX4 genes. SS18 and SSX are transcriptional cofactors involved in activation and repression of gene transcription...
- Role of the polarity determinant crumbs in suppressing mammalian epithelial tumor progression
[作者：Karp, CM; Tan, TT; Mathew, R; Nelson, D; Mukherjee, C; Degenhardt, K; Karantza-Wadsworth, V; White, E,期刊：Cancer research, 页码：4105-4115 , 文章类型： Article，,卷期：2008年68-11]
- Most tumors are epithelial-derived, and although disruption of polarity and aberrant cellular junction formation is a poor prognosticator in human cancer, the role of polarity determinants in oncogenesis is poorly unders...
- Epigenetic inactivation of the Groucho homologue gene TLE1 in hematologic malignancies
[作者：Fraga, MF; Berdasco, M; Ballestar, E; Ropero, S; Lopez-Nieva, P; Lopez-Serra, L; Martin-Subero, JI; Calasanz, MJ; de Silanes, IL; Setien, F; Casado, S; Fernandez, AF; Siebert, R; Stifani, S; Esteller, M,期刊：Cancer research, 页码：4116-4122 , 文章类型： Article，,卷期：2008年68-11]
- An undifferentiated status and the epigenetic inactivation of tumor-suppressor genes are hallmarks of transformed cells. Promoter CpG island hypermethylation of differentiating genes, however, has rarely been reported. T...
- Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer
[作者：Toyota, M; Suzuki, H; Sasaki, Y; Maruyama, R; Imai, K; Shinomura, Y; Tokino, T,期刊：Cancer research, 页码：4123-4132 , 文章类型： Article，,卷期：2008年68-11]
- Altered expression of microRNA (miRNA) is strongly implicated in cancer, and recent studies have shown that, in cancer, expression of some miRNAs cells is silenced in association with CpG island hypermethylation. To iden...
- TIP30 induces apoptosis under oxidative stress through stabilization of p53 messenger RNA in human hepatocellular carcinoma
[作者：Zhao, J; Chen, JJ; Lu, B; Dong, L; Wang, HJ; Bi, CS; Wu, GB; Guo, HZ; Wu, MC; Guo, YJ,期刊：Cancer research, 页码：4133-4141 , 文章类型： Article，,卷期：2008年68-11]
- Reactive oxygen species (ROS) and cellular oxidant stress have long been associated with cancer. Here, we show that TIP30, also called CC3, regulates p53 mRNA stability and induces apoptosis by sensing of intracellular o...
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