- Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer
[作者：Choi, YL; Takeuchi, K; Soda, M; Inamura, K; Togashi, Y; Hatano, S; Enomoto, M; Hamada, T; Haruta, H; Watanabe, H; Kurashina, K; Hatanaka, H; Ueno, T; Takada, S; Yamashita, Y; Sugiyama, Y; Ishikawa, Y; Mano, H,期刊：Cancer research, 页码：4971-4976 , 文章类型： Article，,卷期：2008年68-13]
- The genome of a subset of non-small-cell lung cancers (NSCLC) harbors a small inversion within chromosome 2 that gives rise to a transforming fusion gene, EML4-ALK, which encodes an activated protein tyrosine kinase. Alt...
- Single-cell transcription site activation predicts chemotherapy response in human colorectal tumors
[作者：Pezo, RC; Gandhi, SJ; Shirley, LA; Pestell, RG; Augenlicht, LH; Singer, RH,期刊：Cancer research, 页码：4977-4982 , 文章类型： Article，,卷期：2008年68-13]
- Candidate gene and pathway approaches, and unbiased gene expression profiling, have identified marker signatures predictive of tumor phenotypes, such as drug sensitivity and invasive or metastatic potential. However, app...
- Transporter-mediated protection against thiopurine-induced hematopoietic toxicity
[作者：Krishnamurthy, P; Schwab, M; Takenaka, K; Nachagari, D; Morgan, J; Leslie, M; Du, W; Boyd, K; Cheok, M; Nakauchi, H; Marzolini, C; Kim, RB; Poonkuzhali, B; Schuetz, E; Evans, W; Relling, M; Schuetz, JD,期刊：Cancer research, 页码：4983-4989 , 文章类型： Article，,卷期：2008年68-13]
- Thiopurines are effective immunosuppressants and anticancer agents, but intracellular accumulation of their active metabolites (6-thioguanine nucleotides, 6-TGN) causes dose-limiting hematopoietic toxicity. Thiopurine S-...
- Noninvasive imaging and quantification of epidermal growth factor receptor kinase activation in vivo
[作者：Li, WR; Li, F; Huang, Q; Frederick, B; Bao, SD; Li, CY,期刊：Cancer research, 页码：4990-4997 , 文章类型： Article，,卷期：2008年68-13]
- Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase (RTK) critical in tumor growth and a major target for anticancer drug development. However, thus far, there is no effective system to monitor its acti...
- Complement-dependent tumor cell lysis triggered by combinations of epidermal growth factor receptor antibodies
[作者：Dechant, M; Weisner, W; Berger, S; Peipp, M; Beyer, T; Schneider-Merck, T; van Bueren, JJL; Bleeker, WK; Parren, PWHI; van de Winkel, JGJ; Valerius, T,期刊：Cancer research, 页码：4998-5003 , 文章类型： Article，,卷期：2008年68-13]
- Therapeutic monoclonal antibodies against the epidermal growth factor receptor (EGFR) have advanced the treatment of colon and head and neck cancer, and show great promise for the development of treatments for other soli...
- miR-206 expression is down-regulated in estrogen receptor alpha-positive human breast cancer
[作者：Kondo, N; Toyama, T; Sugiura, H; Fujii, Y; Yamashita, H,期刊：Cancer research, 页码：5004-5008 , 文章类型： Article，,卷期：2008年68-13]
- Expression levels of estrogen receptor (ER) et govern estrogen-dependent growth, response to endocrine therapy, and prognosis in ER alpha-positive breast cancer. Multiple mechanisms involved in altering ER alpha gene exp...
- Frequent detection of Merkel cell polyomavirus in human Merkel cell carcinomas and identification of a unique deletion in the VP1 gene
[作者：Kassem, A; Schopflin, A; Diaz, C; Weyers, WG; Stickeler, E; Werner, M; zur Hausen, A,期刊：Cancer research, 页码：5009-5013 , 文章类型： Article，,卷期：2008年68-13]
- Merkel cell carcinoma (MCC) is a rare but very aggressive human malignancy of the elderly or immunosuppressed patients. Recently, the clonal integration of a new human polyoma virus, which was termed Merkel cell polyomav...
- The cullin 4B-based UV-damaged DNA-binding protein ligase binds to UV-damaged chromatin and ubiquitinates histone H2A
[作者：Guerrero-Santoro, J; Kapetanaki, MG; Hsieh, CL; Gorbachinsky, I; Levine, AS; Rapic-Otrin, V,期刊：Cancer research, 页码：5014-5022 , 文章类型： Article，,卷期：2008年68-13]
- By removing UV-induced lesions from DNA, the nucleotide excision repair (NER) pathway preserves the integrity of the genome. The UV-damaged DNA-binding (UV-DDB) protein complex is involved in the recognition of chromatin...
- A syngeneic variance library for functional annotation of human variation: Application to BRCA2
[作者：Hucl, T; Rago, C; Gallmeier, E; Brody, JR; Gorospe, M; Kern, SE,期刊：Cancer research, 页码：5023-5030 , 文章类型： Article，,卷期：2008年68-13]
- The enormous scope of natural human genetic variation is now becoming defined. To accurately annotate these variants, and to identify those with clinical importance, is often difficult to assess through functional assays...
- c-Jun NH2-terminal kinase 1 is a critical regulator for the development of gastric cancer in mice
[作者：Shibata, W; Maeda, S; Hikiba, Y; Yanai, A; Sakamoto, K; Nakagawa, H; Ogura, K; Karin, M; Omata, M,期刊：Cancer research, 页码：5031-5039 , 文章类型： Article，,卷期：2008年68-13]
- c-Jun NH2-terminal kinase (JNK) links several cellular processes, including proliferation and survival, and is believed to be involved in carcinogenesis. However, the role of JNK in gastric tumorigenesis is unknown. Immu...
- 15-hydroxyprostaglandin dehydrogenase is a target of hepatocyte nuclear factor 3 beta and a tumor suppressor in lung cancer
[作者：Huang, GS; Eisenberg, R; Yan, M; Monti, S; Lawrence, E; Fu, PF; Walbroehl, J; Loewenberg, E; Golub, T; Merchan, J; Tenen, DG; Markowitz, SD; Halmos, B,期刊：Cancer research, 页码：5040-5048 , 文章类型： Article，,卷期：2008年68-13]
- The forkhead transcription factor hepatocyte nuclear factor 3 beta (HNF3 beta) is essential in foregut development and the regulation of lung-specific genes. HNF3 beta expression leads to growth arrest and apoptosis in l...
- Methylation mediated silencing of microRNA-1 gene and its role in hepatocellular carcinogenesis
[作者：Datta, J; Kutay, H; Nasser, MW; Nuovo, GJ; Wang, B; Majumder, S; Liu, CG; Volinia, S; Croce, CM; Schmittgen, TD; Ghoshal, K; Jacob, ST,期刊：Cancer research, 页码：5049-5058 , 文章类型： Article，,卷期：2008年68-13]
- MicroRNAs (miR) are a class of small (similar to 21 nucleotide) noncoding RNAs that, in general, negatively regulate gene expression. Some miRs harboring CGIs undergo methylation-mediated silencing, a characteristic of m...
- Zebrafish with mutations in mismatch repair genes develop neurofibromas and other tumors
[作者：Feitsma, H; Kuiper, RV; Korving, J; Nijman, IJ; Cuppen, E,期刊：Cancer research, 页码：5059-5066 , 文章类型： Article，,卷期：2008年68-13]
- Defective mismatch repair (MMR) in humans causes hereditary nonpolyposis colorectal cancer. This genetic predisposition to colon cancer is linked to heterozygous familial mutations, and loss-of-heterozygosity is necessar...
- Frequent inactivation of a putative tumor suppressor, angiopoietin-like protein 2, in ovarian cancer
[作者：Kikuchi, R; Tsuda, H; Kozaki, K; Kanai, Y; Kasamatsu, T; Sengoku, K; Hirohashi, S; Inazawa, J; Imoto, I,期刊：Cancer research, 页码：5067-5075 , 文章类型： Article，,卷期：2008年68-13]
- Angiopoietin-like protein 2 (ANGPTL2) is a secreted protein belonging to the angiopoietin family, the members of which are implicated in various biological processes, although its receptor remains unknown. We identified ...
- Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27(Kip1) at the transcriptional and posttranscriptional levels
[作者：Morishita, D; Katayama, R; Sekimizu, K; Tsuruo, T; Fujita, N,期刊：Cancer research, 页码：5076-5085 , 文章类型： Article，,卷期：2008年68-13]
- The serine/threonine kinase Pim is known to promote cell cycle progression and to inhibit apoptosis leading to tumorigenesis. However, the precise mechanisms remain unclear. We show, herein, that all the Pim family membe...
- Inhibition of fibroblast growth factor 19 reduces tumor growth by modulating beta-catenin signaling
[作者：Pai, R; Dunlap, D; Qing, J; Mohtashemi, I; Hotzel, K; French, DM,期刊：Cancer research, 页码：5086-5095 , 文章类型： Article，,卷期：2008年68-13]
- Fibroblast growth factors (FGF) play important roles in development, angiogenesis, and cancer. FGF19 uniquely binds to FGF receptor 4 (FGFR4). Our previous study has shown that FGF19 transgenic tumors have an activated W...
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