- 17 beta-estradiol mobilizes bone marrow-derived endothelial progenitor cells to tumors
[作者：Suriano, R; Chaudhuri, D; Johnson, RS; Lambers, E; Ashok, BT; Kishore, R; Tiwari, RK,期刊：Cancer research, 页码：6038-6042 , 文章类型： Article，,卷期：2008年68-15]
- Neovascularization is critical for tumor growth and development. The cellular mediators for this process are yet to be defined. We discovered that bone marrow-derived endothelial progenitor cells (BM-EPC), having the phe...
- Targeting cancer stem cells through L1CAM suppresses glioma growth
[作者：Bao, SD; Wu, QL; Li, ZZ; Sathornsumetee, S; Wang, H; McLendon, RE; Hjehneland, AB; Rich, JN,期刊：Cancer research, 页码：6043-6048 , 文章类型： Article，,卷期：2008年68-15]
- Malignant gliomas are lethal cancers that display striking cellular heterogeneity. A highly tumorigenic glioma tumor subpopulation, termed cancer stem cells or tumor-initiating cells, promotes therapeutic resistance and ...
- Serum-soluble B7x is elevated in renal cell carcinoma patients and is associated with advanced stage
[作者：Thompson, RH; Zang, XX; Lohse, CM; Leibovich, BC; Slovin, SF; Reuter, VE; Cheville, JC; Blute, ML; Russo, P; Kwon, ED; Allison, JP,期刊：Cancer research, 页码：6054-6058 , 文章类型： Article，,卷期：2008年68-15]
- B7x is the newest member of the B7-CD28 family and is thought to dampen immune responses via negative costimulation. Tumor expression of B7x was recently described in renal cell carcinoma (RCC) and was associated with po...
- Methadone, commonly used as maintenance medication for outpatient treatment of opioid dependence, kills leukemia cells and overcomes chemoresistance
[作者：Friesen, C; Roscher, M; Alt, A; Miltner, E,期刊：Cancer research, 页码：6059-6064 , 文章类型： Article，,卷期：2008年68-15]
- The therapeutic opioid drug methadone (D,L-methadone hydrochloride) is the most commonly used maintenance medication for outpatient treatment of opioid dependence. In our study, we found that methadone is also a potent i...
- Down-regulation of myeloid cell leukemia-1 through inhibiting Erk/Pin 1 pathway by sorafenib facilitates chemosensitization in breast cancer
[作者：Ding, QQ; Huo, LF; Yang, JY; Xia, WY; Wei, YK; Liao, Y; Chang, CJ; Yang, Y; Lai, CC; Lee, DF; Yen, CJ; Chen, YJR; Hsu, JM; Kuo, HP; Lin, CY; Tsai, FJ; Li, LY; Tsai, CH; Hung, MC,期刊：Cancer research, 页码：6109-6117 , 文章类型： Article，,卷期：2008年68-15]
- Myeloid cell leukemia-1 (Mcl-1), a Bel-2-like antiapoptotic protein, plays a role in cell immortalization and chemoresistance in a number of human malignancies. A peptidylprolyl cis/trans isomerase, Pinl is involved in m...
- Ugene, a newly identified protein that is commonly overexpressed in cancer and binds uracil DNA glycosylase
[作者：Guo, CG; Zhang, XD; Fink, SP; Platzer, P; Wilson, K; Willson, JKV; Wang, ZH; Markowitz, SD,期刊：Cancer research, 页码：6118-6126 , 文章类型： Article，,卷期：2008年68-15]
- Expression microarrays identified a novel transcript, designated as Ugene, whose expression is absent in normal colon and colon adenomas, but that is commonly induced in malignant colon cancers. These findings were valid...
- Cyclic AMP response element-binding protein overexpression: A feature associated with negative prognosis in never smokers with non-small cell lung cancer
[作者：Seo, HS; Liu, DD; Bekele, BN; Kim, MK; Pisters, K; Lippman, SM; Wistuba, II; Koo, JS,期刊：Cancer research, 页码：6065-6073 , 文章类型： Article，,卷期：2008年68-15]
- Lung cancer is the leading cause of cancer deaths worldwide. Recent advances in targeted therapies hold promise for the development of new treatments for certain subsets of cancer patients by targeting specific signaling...
- Defective transcription/repair factor IN recruitment to specific UV lesions in trichothiodystrophy syndrome
[作者：Chigancas, V; Lima-Bessa, KM; Stary, A; Menck, CFM; Sarasin, A,期刊：Cancer research, 页码：6074-6083 , 文章类型： Article，,卷期：2008年68-15]
- Most trichothiodystrophy (TTD) patients present mutations in the xeroderma pigmentosum D (XPD) gene, coding for a subunit of the transcription/repair factor IIH (TFHH) complex involved in nucleotide excision repair (NER)...
- Integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer
[作者：Stemke-Hale, K; Gonzalez-Angulo, AM; Lluch, A; Neve, RM; Kuo, WL; Davies, M; Carey, M; Hu, Z; Guan, Y; Sahin, A; Symmans, WF; Pusztai, L; Nolden, LK; Horlings, H; Berns, K; Hung, MC; van de Vijver, MJ; Valero, V; Gray, JW; Bernards, R; Mills, GB; Hennessy, BT,期刊：Cancer research, 页码：6084-6091 , 文章类型： Article，,卷期：2008年68-15]
- Phosphatidylinositol 3-kinase (Pl3K)/AKT pathway aberrations are common in cancer. By applying mass spectroscopybased sequencing and reverse-phase protein arrays to 547 human breast cancers and 41 cell lines, we determin...
- A six-gene signature predicting breast cancer lung metastasis
[作者：Landemaine, T; Jackson, A; Bellahcene, A; Rucci, N; Sin, S; Abad, BM; Sierra, A; Boudinet, A; Guinebretiere, JM; Ricevuto, E; Nogues, C; Briffod, M; Bieche, I; Cherel, P; Garcia, T; Castronovo, V; Teti, A; Lidereau, R; Driouch, K,期刊：Cancer research, 页码：6092-6099 , 文章类型： Article，,卷期：2008年68-15]
- The lungs are a frequent target of metastatic breast cancer cells, but the underlying molecular mechanisms are unclear. All existing data were obtained either using statistical association between gene expression measure...
- Neutrophil gelatinase-associated lipocalin: A novel suppressor of invasion and angiogenesis in pancreatic cancer
[作者：Tong, ZM; Kunnumakkara, AB; Wang, HM; Matsuo, Y; Diagaradjane, P; Harikumar, KB; Ramachandran, V; Sung, B; Chakraborty, A; Bresalier, RS; Logsdon, C; Aggarwal, BB; Krishnan, S; Guha, S,期刊：Cancer research, 页码：6100-6108 , 文章类型： Article，,卷期：2008年68-15]
- Neutrophil gelatinase-associated lipocalin (NGAL) is a 25-kDa secreted acute phase protein, which is also up-regulated in multiple cancers, including breast, lung, and pancreas. Recently, NGAL has been proposed as an ear...
- Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton
[作者：Barkan, D; Kleinman, H; Simmons, JL; Asmussen, H; Kamaraju, AK; Hoenorhoff, MJ; Liu, ZY; Costes, SV; Cho, EH; Lockett, S; Khanna, C; Chambers, AF; Green, JE,期刊：Cancer research, 页码：6241-6250 , 文章类型： Article，,卷期：2008年68-15]
- Metastatic breast cancer may emerge from latent tumor cells that remain dormant at disseminated sites for many years. Identifying mechanisms regulating the switch from dormancy to proliferative metastatic growth has been...
- Effect of ablation or inhibition of stromal matrix metalloproteinase-9 on lung metastasis in a breast cancer model is dependent on genetic background
[作者：Martin, MD; Carter, KJ; Jean-Philippe, SR; Chang, M; Mobashery, S; Thiolloy, S; Lynch, CC; Matrisian, LM; Fingleton, B,期刊：Cancer research, 页码：6251-6259 , 文章类型： Article，,卷期：2008年68-15]
- Matrix metalloproteinases (MMP) are a family of enzymes with a myriad of functions. Lately, we have come to realize that broad-spectrum inhibition of these enzymes, as was tried unsuccessfully in multiple phase III trial...
- A pivotal role for heat shock protein 90 in Ewing Sarcoma resistance to anti-insulin-like growth factor 1 receptor treatment: in vitro and in vivo study
[作者：Martins, AS; Ordonez, JL; Garcia-Sanchez, A; Herrero, D; Sevillano, V; Osuna, D; Mackintosh, C; Caballero, G; Otero, AP; Poremba, C; Madoz-Gurpide, J; de Alava, E,期刊：Cancer research, 页码：6260-6270 , 文章类型： Article，,卷期：2008年68-15]
- Ewing Sarcoma (ES) shows several deregulated autocrine loops mediating cell survival and proliferation. Therefore, their blockade is a promising therapeutic approach. We previously reported the in vitro effect of insulin...
- Phosphatidylinostol 3-kinase inhibition broadly sensitizes glioblastoma cells to death receptor- and drug-induced apoptosis
[作者：Opel, D; Westhoff, MA; Bender, A; Braun, V; Debatin, KM; Fulda, S,期刊：Cancer research, 页码：6271-6280 , 文章类型： Article，,卷期：2008年68-15]
- The aberrant activity of the phosphatidylinositol 3-kinase (PI3K) pathway has been reported to correlate with adverse clinical outcome in human glioblastoma in vivo. However, the question of how this survival network can...
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