- Combination therapy with cisplatin and anti-4-1BB: Synergistic anticancer effects and amelioration of cisplatin-induced nephrotoxicity
[作者：Kim, YH; Choi, BK; Kim, KH; Kang, SW; Kwon, BS,期刊：Cancer research, 页码：7264-7269 , 文章类型： Article，,卷期：2008年68-18]
- Anti-4-1BB and cisplatin showed synergistic anticancer effects in the CT-26 colon carcinoma model, producing complete regression in > 60% of mice with either preventive or therapeutic treatment. The tumor-free mice forme...
- LKB1 is necessary for Akt-mediated phosphorylation of proapoptotic proteins
[作者：Zhong, DS; Liu, XJ; Khuri, FR; Sun, SY; Vertino, PM; Zhou, W,期刊：Cancer research, 页码：7270-7277 , 文章类型： Article，,卷期：2008年68-18]
- LKB1 plays the role of tumor suppressor, opposite to Akt, by negatively regulating mammalian target of rapamycin through the activation of AMP-activated protein kinase and TSC signaling. We have discovered a novel, poten...
- A novel, macrophage migration inhibitory factor suicide substrate inhibits motility and growth of lung cancer cells
[作者：Winner, M; Meier, J; Zierow, S; Rendon, BE; Crichlow, GV; Riggs, R; Bucala, R; Leng, L; Smith, N; Lolis, E; Trent, JO; Mitchell, RA,期刊：Cancer research, 页码：7253-7257 , 文章类型： Article，,卷期：2008年68-18]
- Although chemokine and growth factor receptors are attractive and popular targets for cancer therapeutic intervention, structure-based targeting of the ligands themselves is generally not considered practical. New eviden...
- Kaiso contributes to DNA methylation-dependent silencing of tumor suppressor genes in colon cancer cell lines
[作者：Lopes, EC; Valls, E; Figueroa, ME; Mazur, A; Meng, FG; Chiosis, G; Laird, PW; Schreiber-Agus, N; Greally, JM; Prokhortchouk, E; Melnick, A,期刊：Cancer research, 页码：7258-7263 , 文章类型： Article，,卷期：2008年68-18]
- Aberrant CpG methylation of tumor suppressor gene regulatory elements is associated with transcriptional silencing and contributes to malignant transformation of different tissues. It is presumed that methylated DNA sequ...
- Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation
[作者：Rainey, MD; Charlton, ME; Stanton, RV; Kastan, MB,期刊：Cancer research, 页码：7466-7474 , 文章类型： Article，,卷期：2008年68-18]
- In response to DNA damage, the ATM protein kinase activates signal transduction pathways essential for coordinating cell cycle progression with DNA repair. In the human disease ataxia-telangiectasia, mutation of the. ATM...
- Development of a small-molecule serum- and glucocorticoid-regulated kinase-1 antagonist and its evaluation as a prostate cancer therapeutic
[作者：Sherk, AB; Frigo, DE; Schnackenberg, CG; Bray, JD; Laping, NJ; Trizna, W; Hammond, M; Patterson, JR; Thompson, SK; Kazmin, D; Norris, JD; McDonnell, DP,期刊：Cancer research, 页码：7475-7483 , 文章类型： Article，,卷期：2008年68-18]
- Androgens, through their actions on the androgen receptor (AR), are required for the development of the prostate and contribute to the pathologic growth dysregulation observed in prostate cancers. Consequently, androgen ...
- Nordihydroguaiaretic acid inhibits an activated fibroblast growth factor receptor 3 mutant and blocks downstream signaling in multiple myeloma cells
[作者：Meyer, AN; McAndrew, CW; Donoghue, DJ,期刊：Cancer research, 页码：7362-7370 , 文章类型： Article，,卷期：2008年68-18]
- Activating mutations within fibroblast growth factor receptor 3 (FGFR3), a receptor tyrosine kinase, are responsible for human skeletal dysplasias including achondroplasia and the neonatal lethal syndromes, Thanatophoric...
- An immortalization-dependent switch in integrin function up-regulates MMP-9 to enhance tumor cell invasion
[作者：Lamar, JM; Pumiglia, KM; DiPersio, CM,期刊：Cancer research, 页码：7371-7379 , 文章类型： Article，,卷期：2008年68-18]
- Integrins, the major receptors for cell adhesion to the extracellular matrix, play important roles during tumor progression. However, it is still unclear whether genetic lesions that occur during carcinoma development ca...
- Acute wounds accelerate tumorigenesis by a T cell-dependent mechanism
[作者：Stuelten, CH; Barbul, A; Busch, JI; Sutton, E; Katz, R; Sato, M; Wakefield, LM; Roberts, AB; Niederhuber, JE,期刊：Cancer research, 页码：7278-7282 , 文章类型： Article，,卷期：2008年68-18]
- We investigated the influence of acute wounding on tumor growth in a syngeneic mouse breast cancer model. Metastatic mouse breast cancer cells (4T1) were orthotopically injected into the mammary fat pads of BALB/c mice, ...
- Curcumin inhibits the proteasome activity in human colon cancer cells in vitro and in vivo
[作者：Milacic, V; Banerjee, S; Landis-Piwowar, KR; Sarkar, FH; Majumdar, APN; Dou, QP,期刊：Cancer research, 页码：7283-7292 , 文章类型： Article，,卷期：2008年68-18]
- Curcumin (diferuloylmethane) is the major active ingredient of turmeric (Curcuma longa) used in South Asian cuisine for centuries. Curcumin has been shown to inhibit the growth of transformed cells and to have a number o...
- Glucocorticoids antagonize estrogens by glucocorticoid receptor-mediated activation of estrogen sulfotransferase
[作者：Gong, H; Jarzynka, MJ; Cole, TJ; Lee, JH; Wada, T; Zhang, B; Gao, J; Song, WC; DeFranco, DB; Cheng, SY; Xie, W,期刊：Cancer research, 页码：7386-7393 , 文章类型： Article，,卷期：2008年68-18]
- Glucocorticoids and estrogens are two classes of steroid hormones that have essential but distinct physiologic functions. Estrogens also represent a risk factor for breast cancer. It has been suggested that glucocorticoi...
- A novel gene expression profile in lymphatics associated with tumor growth and nodal metastasis
[作者：Clasper, S; Royston, D; Baban, D; Cao, YH; Ewers, S; Butz, S; Vestweber, D; Jackson, DG,期刊：Cancer research, 页码：7293-7303 , 文章类型： Article，,卷期：2008年68-18]
- Invasion of lymphatic vessels is a key step in the metastasis of primary tumors to draining lymph nodes. Although the process is enhanced by tumor lymphangiogenesis, it is unclear whether this is a con sequence of increa...
- Cyp1b1 exerts opposing effects on intestinal tumorigenesis via exogenous and endogenous substrates
[作者：Halberg, RB; Larsen, MC; Elmergreen, TL; Ko, AY; Irving, AA; Clipson, L; Jefcoate, CR,期刊：Cancer research, 页码：7394-7402 , 文章类型： Article，,卷期：2008年68-18]
- Cytochrome P450 1B1 (Cyp1b1) metabolism contributes to physiologic functions during embryogenesis but also to carcinogenic activation of polycyclic aromatic hydrocarbons (PAH). We generated Cyp1b1-deficient mice carrying...
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