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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共60条记录   Ectopic expression of P-cadherin correlates with promoter hypomethylation early in colorectal carcinogenesis and enhanced intestinal crypt fission in vivo [作者：Milicic, A; Harrison, LA; Goodlad, RA; Hardy, RG; Nicholson, AM; Presz, M; Sieber, O; Santander, S; Pringle, JH; Mandir, N; East, P; Obszynska, J; Sanders, S; Piazuelo, E; Shaw, J; Harrison, R; Tomlinson, IP; McDonald, SAC; Wright, NA; Jankowski, JAZ,期刊：Cancer research, 页码：7760-7768 , 文章类型： Article，,卷期：2008年68-19] P-cadherin is normally expressed in the basal layer of squamous epithelia and absent from the healthy intestine and colon. We have previously shown it to be expressed in all inflamed, hyperplastic, and dysplastic intesti... Prolyl isomerase cyclophilin A regulation of Janus-activated kinase 2 and the progression of human breast cancer [作者：Zheng, JM; Koblinski, JE; Dutson, LV; Feeney, YB; Clevenger, CV,期刊：Cancer research, 页码：7769-7778 , 文章类型： Article，,卷期：2008年68-19] The activation of the Janus-activated kinase 2 (Jak2) tyrosine kinase following ligand binding has remained incompletely characterized at the mechanistic level. We report that the peptidyl-prolyl isomerase (PPI) cyclophi... Runx2 transcriptional activation of Indian Hedgehog and a downstream bone metastatic pathway in breast cancer cells [作者：Pratap, J; Wixted, JJ; Gaur, T; Zaidi, SK; Dobson, J; Gokul, KD; Hussain, S; van Wijnen, AJ; Stein, JL; Stein, GS; Lian, JB,期刊：Cancer research, 页码：7795-7802 , 文章类型： Article，,卷期：2008年68-19] Runx2, required for bone formation, is ectopically expressed in breast cancer cells. To address the mechanism by which Runx2 contributes to the osteolytic disease induced by MDA-MB-231 cells, we investigated the effect o... Dietary induction of colonic tumors in a mouse model of sporadic colon cancer [作者：Yang, K; Kurihara, N; Fan, K; Newmark, H; Rigas, B; Bancroft, L; Corner, G; Livote, E; Lesser, M; Edelmann, W; Velcich, A; Lipkin, M; Augenlicht, L,期刊：Cancer research, 页码：7803-7810 , 文章类型： Article，,卷期：2008年68-19] A defined rodent "new Western diet" (NWD), which recapitulates intake levels of nutrients that are major dietary risk factors for human colon cancer, induced colonic tumors when fed to wild-type C57B1/6 mice for 1.5 to 2... Breast tumor kinase phosphorylates p190RhoGAP to regulate Rho and Ras and promote breast carcinoma growth, migration, and invasion [作者：Shen, CH; Chen, HY; Lin, MS; Li, FY; Chang, CC; Kuo, ML; Settleman, J; Chen, RH,期刊：Cancer research, 页码：7779-7787 , 文章类型： Article，,卷期：2008年68-19] Breast tumor kinase (Brk), an Src-like nonreceptor tyrosine kinase, is overexpressed in breast cancer and several other cancer types. Our previous study indicates that Brk promotes cell migration and tumor invasion by ph... Brn-2 represses microphthalmia-associated transcription factor expression and marks a distinct subpopulation of microphthalmia-associated transcription factor-negative melanoma cells [作者：Goodall, J; Carreira, S; Denat, L; Kobi, D; Davidson, I; Nuciforo, P; Sturm, RA; Larue, L; Goding, CR,期刊：Cancer research, 页码：7788-7794 , 文章类型： Article，,卷期：2008年68-19] The origin of tumor heterogeneity is poorly understood, yet it represents a major barrier to effective therapy. In melanoma and in melanocyte development, the microphthalmia-associated transcription factor (Mitf) control... The mammary progenitor marker CD61/beta 3 integrin identifies cancer stem cells in mouse models of mammary tumorigenesis [作者：Vaillant, F; Asselin-Labat, ML; Shackleton, M; Forrest, NC; Lindeman, GJ; Visvader, JE,期刊：Cancer research, 页码：7711-7717 , 文章类型： Article，,卷期：2008年68-19] The cells of origin and mechanisms that underpin tumor heterogeneity in breast cancer are poorly understood. Here, we have examined three mouse models of mammary tumorigenesis (MMTV-wnt-1, MMTV-neu, and p53(+/-)) for cha... Mutations in the focal adhesion targeting region of deleted in liver cancer-1 attenuate their expression and function [作者：Liao, YC; Shih, YP; Lo, SH,期刊：Cancer research, 页码：7718-7722 , 文章类型： Article，,卷期：2008年68-19] Deleted in liver cancer-1 (DLC-1) is a RhoGTPase-activating protein (RhoGAP) domain containing tumor suppressor that is often down-regulated in various cancer types. Previously, we have shown that DLC-1 is recruited to f... SCL/TAL1 interrupting locus derepresses GLI1 from the negative control of Suppressor-of-Fused in pancreatic cancer cell [作者：Kasai, K; Inaguma, S; Yoneyama, A; Yoshikawa, K; Ikeda, H,期刊：Cancer research, 页码：7723-7729 , 文章类型： Article，,卷期：2008年68-19] As a physically binding protein of GLI1 transcription factor, Suppressor-of-Fused (SUFU) has been placed in the center of negative regulation of Hedgehog (Hh) signaling. SUFU tethers GLI1 in cytoplasm, and in some circum... Identification of transformation-related pathways in a breast epithelial cell model using a ribonomics approach [作者：Mazan-Mamczarz, K; Hagner, PR; Dai, BJ; Wood, WH; Zhang, YQ; Becker, KG; Liu, ZQ; Gartenhaus, RB,期刊：Cancer research, 页码：7730-7735 , 文章类型： Article，,卷期：2008年68-19] The aberrant expression of many genes is a common feature in the malignant transformation of cells. In mammalian cells, posttranscriptional gene regulatory processes are emerging as critical determinants controlling gene... Activation of signal transducer and activator of transcription 3 through a phosphomimetic serine 727 promotes prostate tumorigenesis independent of tyrosine 705 phosphorylation [作者：Qin, HR; Kim, HJ; Kim, JY; Hurt, EM; Klarmann, GJ; Kawasaki, BT; Serrat, MAD; Farrar, WL,期刊：Cancer research, 页码：7736-7741 , 文章类型： Article，,卷期：2008年68-19] Aberrantly activated signal transducer and activator of transcription 3 (Stat3) is implicated in the development of various human cancers. Y705 phosphorylation is conventionally thought to be required for Stat3 signal-de... The polycomb gene product BMI1 contributes to the maintenance of tumor-initiating side population cells in hepatocellular carcinoma [作者：Chiba, T; Miyagi, S; Saraya, A; Aoki, R; Seki, A; Morita, Y; Yonemitsu, Y; Yokosuka, O; Taniguchi, H; Nakauchi, H; Iwama, A,期刊：Cancer research, 页码：7742-7749 , 文章类型： Article，,卷期：2008年68-19] Side population (SP) cell analysis and sorting have been successfully applied to hepatocellular carcinoma (HCC) cell lines to identify a minor cell population with cancer stem cell properties. However, the molecular mech... Prostaglandin E-2 regulates tumor angiogenesis in prostate cancer [作者：Jain, S; Chakraborty, G; Raja, R; Kale, S; Kundu, GC,期刊：Cancer research, 页码：7750-7759 , 文章类型： Article，,卷期：2008年68-19] In cancer management, the cyclooxygenase (COX)-targeted approach has shown great promise in anticancer therapeutics. However, the use of COX-2 inhibitors has side effects and health hazards; thus, targeting its major met... Disruption of NAD(P)H : quinone oxidoreductase 1 gene in mice leads to radiation-induced myeloproliferative disease [作者：Iskander, K; Barrios, RJ; Jaiswal, AK,期刊：Cancer research, 页码：7915-7922 , 文章类型： Article，,卷期：2008年68-19] NAD(P)H:quinone oxidoreductase 1 null (NQO1(-/-)) Mice exposed to 3 Gy of gamma-radiation showed an increase in neutrophils, bone marrow hypercellularity, and enlarged lymph nodes and spleen. The spleen showed disrupted ... Nuclear survivin abrogates multiple cell cycle checkpoints and enhances viral oncolysis [作者：Connell, CM; Wheatley, SP; McNeish, IA,期刊：Cancer research, 页码：7923-7931 , 文章类型： Article，,卷期：2008年68-19] Survivin (BIRC5) promotes cell division and survival with roles as chromosomal passenger protein and inhibitor of apoptosis protein (LAP). It is overexpressed in many cancers and is associated with resistance to chemothe... Validation of the p21-activated kinases as targets for inhibition in neurofibromatosis type [作者：Yi, CL; Wilker, EW; Yaffe, MB; Stemmer-Rachamimov, A; Kissil, JL,期刊：Cancer research, 页码：7932-7937 , 文章类型： Article，,卷期：2008年68-19] Neurofibromatosis type 2 (NF2) is a dominantly inherited cancer disorder caused by mutations at the NF2 gene locus. Merlin, the protein product of the NF2 gene, has been shown to negatively regulate Rac1 signaling by inh...