- Netrin-1 Induces Apoptosis in Human Cervical Tumor Cells via the TAp73 alpha Tumor Suppressor
[作者:Roperch, JP; El Ouadrani, K; Hendrix, A; Emami, S; De Wever, O; Melino, G; Gespach, C,期刊:Cancer research, 页码:8231-8239 , 文章类型: Article,,卷期:2008年68-20]
- Netrins and their receptors deleted in colon cancer (DCC), neogenin, UNC5, and integrins are involved in axon guidance, epithelial morphogenesis, vascular pattering, cancer cell survival, invasion, tumor angiogenesis, an...
- Sperm-Associated Antigen 9 Is Associated With Tumor Growth, Migration, and Invasion in Renal Cell Carcinoma
[作者:Garg, M; Kanojia, D; Khosla, A; Dudha, N; Sati, S; Chaurasiya, D; Jagadish, N; Seth, A; Kumar, R; Gupta, S; Gupta, A; Lohiya, NK; Suri, A,期刊:Cancer research, 页码:8240-8248 , 文章类型: Article,,卷期:2008年68-20]
- Renal cell carcinoma (RCC) represents one of the most resistant tumors to radiation and chemotherapy. Current therapies for RCC patients are inefficient due to the lack of diagnostic and therapeutic markers. Our recent s...
- Characterization of Naturally Occurring HPV16 Integration Sites Isolated from Cervical Keratinocytes under Noncompetitive Conditions
[作者:Dall, KL; Scarpini, CG; Roberts, I; Winder, DM; Stanley, MA; Muralidhar, B; Herdman, MT; Pett, MR; Coleman, N,期刊:Cancer research, 页码:8249-8259 , 文章类型: Article,,卷期:2008年68-20]
- As the high-risk human papillomavirus (HPV) integrants seen in anogenital carcinomas represent the end-point of a clonal selection process, we used the W12 model to study the naturally occurring integration events that e...
- Feedback Mechanisms Promote Cooperativity for Small Molecule Inhibitors of Epidermal and Insulin-Like Growth Factor Receptors
[作者:Buck, E; Eyzaguirre, A; Rosenfeld-Franklin, M; Thomson, S; Mulvihill, M; Barr, S; Brown, E; O'Connor, M; Yao, Y; Pachter, J; Miglarese, M; Epstein, D; Iwata, KK; Haley, JD; Gibson, NW; Ji, QS,期刊:Cancer research, 页码:8322-8332 , 文章类型: Article,,卷期:2008年68-20]
- Epidermal growth factor receptor (EGFR) and insulin-like growth factor-I receptor (IGF-IR) can cooperate to regulate tumor growth and survival, and synergistic growth inhibition has been reported for combined blockade of...
- The Thioredoxin System Mediates Redox-Induced Cell Death in Human Colon Cancer Cells: Implications for the Mechanism of Action of Anticancer Agents
[作者:Sun, Y; Rigas, B,期刊:Cancer research, 页码:8269-8277 , 文章类型: Article,,卷期:2008年68-20]
- Anticancer agents act, at least in part, by inducing reactive oxygen and nitrogen species (RONS). We examined the redox effect on SW480 and HT-29 colon cancer cells of four anticancer compounds, arsenic trioxide, phospho...
- Arsenic Exposure In utero Exacerbates Skin Cancer Response in Adulthood with Contemporaneous Distortion of Tumor Stem Cell Dynamics
[作者:Waalkes, MP; Liu, J; Germolee, DR; Trempus, CS; Cannon, RE; Tokar, EJ; Tennant, RW; Ward, JM; Diwan, BA,期刊:Cancer research, 页码:8278-8285 , 文章类型: Article,,卷期:2008年68-20]
- Arsenic is a carcinogen with transplacental activity that can affect human skin stem cell population dynamics in vitro by blocking exit into differentiation pathways. Keratinocyte stem cells (KSC) are probably a key targ...
- Suppression of the Negative Regulator LRIG1 Contributes to ErbB2 Overexpression in Breast Cancer
[作者:Miller, JK; Shattuck, DL; Ingalla, EQ; Yen, LL; Borowsky, AD; Young, LJT; Cardiff, RD; Carraway, KL; Sweeney, C,期刊:Cancer research, 页码:8286-8294 , 文章类型: Article,,卷期:2008年68-20]
- The ErbB2 receptor tyrosine kinase is overexpressed in similar to 25% of breast tumors and contributes to poor patient prognosis and therapeutic resistance. Here, we examine the role of the recently discovered ErbB negat...
- Semaphorin 3B Inhibits the Phosphatidylinositol 3-Kinase/Akt Pathway through Neuropilin-1 in Lung and Breast Cancer Cells
[作者:Castro-Rivera, E; Ran, S; Brekken, RA; Minna, JD,期刊:Cancer research, 页码:8295-8303 , 文章类型: Article,,卷期:2008年68-20]
- Semaphorin 3B (SEMA3B), located at 3p21.3, is a secreted member of the semaphorin family important in axonal guidance. SEMA3B undergoes allele and expression loss in lung and breast cancer and can function as a tumor sup...
- Targeted and Nontargeted Effects of Ionizing Radiation That Impact Genomic Instability
[作者:Maxwell, CA; Fleisch, MC; Costes, SV; Erickson, AC; Boissiere, A; Gupta, R; Ravani, SA; Parvin, B; Barcellos-Hoff, MH,期刊:Cancer research, 页码:8304-8311 , 文章类型: Article,,卷期:2008年68-20]
- Radiation-induced genomic instability, in which the progeny of irradiated cells display a high frequency of nonclonal genomic damage, occurs at a frequency inconsistent with mutation. We investigated the mechanism of thi...
- Src and ADAM-17-Mediated Shedding of Transforming Growth Factor-alpha Is a Mechanism of Acute Resistance to TRAIL
[作者:Van Schaeybroeck, S; Kelly, DM; Kyula, J; Stokesberry, S; Fennell, DA; Johnston, PG; Longley, DB,期刊:Cancer research, 页码:8312-8321 , 文章类型: Article,,卷期:2008年68-20]
- Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL/Apo-2L) has emerged as a promising anticancer agent. However, resistance to TRAIL is likely to be a major problem, and sensitization of cancer cells to TRAIL...
- MicroRNA-7, a Homeobox D10 Target, Inhibits p21-Activated Kinase 1 and Regulates Its Functions
[作者:Reddy, SDN; Ohshiro, K; Rayala, SK; Kumar, R,期刊:Cancer research, 页码:8195-8200 , 文章类型: Article,,卷期:2008年68-20]
- MicroRNAs are noncoding RNAs that inhibit the expression of their targets in a sequence-specific manner and play crucial roles during oncogenesis. Here we show that microRNA-7 (miR-7) inhibits p21-activated kinase I (Pak...
- The Polarity Protein Par6 Induces Cell Proliferation and Is Overexpressed in Breast Cancer
[作者:Nolan, ME; Aranda, V; Lee, S; Lakshmi, B; Basu, S; Allred, DC; Muthuswamy, SK,期刊:Cancer research, 页码:8201-8209 , 文章类型: Article,,卷期:2008年68-20]
- The polarity protein complex Par6/atypical protein kinase (aPKC)/Cdc42 regulates polarization processes during epithelial morphogenesis, astrocyte migration, and axon specification. We, as well as others, have shown that...
- Phosphorylated Caveolin-1 Regulates Rho/ROCK-Dependent Focal Adhesion Dynamics and Tumor Cell Migration and Invasion
[作者:Joshi, B; Strugnell, SS; Goetz, JG; Kojic, LD; Cox, ME; Griffith, OL; Chan, SK; Jones, SJ; Leung, SP; Masoudi, H; Leung, S; Wiseman, SM; Nabi, IR,期刊:Cancer research, 页码:8210-8220 , 文章类型: Article,,卷期:2008年68-20]
- Rho/ROCK signaling and caveolin-1 (Cav1) are implicated in tumor cell migration and metastasis; however, the underlying molecular mechanisms remain poorly defined. Cav1 was found here to be an independent predictor of de...
- Activated G alpha(13) Impairs Cell Invasiveness through p190RhoGAP-Mediated Inhibition of RhoA Activity
[作者:Bartolome, RA; Wright, N; Molina-Ortiz, I; Sanchez-Luque, FJ; Teixido, J,期刊:Cancer research, 页码:8221-8230 , 文章类型: Article,,卷期:2008年68-20]
- The GTPase RhoA is a downstream target of heterotrimeric G(13) proteins and plays key roles in cell migration and invasion. Here, we show that expression in human melanoma cells of a constitutively active, GTPase-deficie...
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