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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共46条记录   Tissue Factor Regulation by Epidermal Growth Factor Receptor and Epithelial-to-Mesenchymal Transitions: Effect on Tumor Initiation and Angiogenesis [作者：Milsom, CC; Yu, JL; Mackman, N; Micallef, J; Anderson, GM; Guha, A; Rak, JW,期刊：Cancer research, 页码：10068-10076 , 文章类型： Article，,卷期：2008年68-24] ErbB oncogenes drive the progression of several human cancers. Our study shows that in human carcinoma (A431) and glioma (U373) cells, the oncogenic forms of epidermal growth factor receptor (EGFR; including EGFRvIII) tr... Approaches to Complex Pathways in Molecular Epidemiology: Summary of a Special Conference of the American Association for Cancer Research [作者：Thomas, DC; Baurley, JW; Brown, EE; Figueiredo, JC; Goldstein, A; Hazra, A; Wilson, RT; Rothman, N,期刊：Cancer research, 页码：10028-10030 , 文章类型： Article，,卷期：2008年68-24] Lapatinib (Tykerb, GW572016) reverses multidrug resistance in cancer cells by inhibiting the activity of ATP-binding cassette subfamily B member 1 and G member 2 (vol 68, pg 7905, 2008) [作者：Dai, C; Tiwari, AK; Wu, CP; Su, X; Wang, SR; Liu, D; Ashby, CR; Huang, Y; Robey, RW; Liang, Y; Chen, L; Shi, CJ; Ambudkar, SV; Chen, ZS; Lapatinib, FL,期刊：Cancer research, 页码：10387-10387 , 文章类型： Correction，,卷期：2008年68-24] Biological Research in the Evolution of Cancer Surgery: A Personal Perspective [作者：Fisher, B,期刊：Cancer research, 页码：10007-10020 , 文章类型： Review，,卷期：2008年68-24] During the 19th, and for most of the 20th century, malignant tumors were removed by mutilating radical anatomic dissection. Advances such as anesthesia, asepsis, and blood transfusion made possible increasingly more radi... p53 Small-Molecule Inhibitor Enhances Temozolomide Cytotoxic Activity against Intracranial Glioblastoma Xenografts [作者：Dinca, EB; Lu, KV; Sarkaria, JN; Pieper, RO; Prados, MD; Haas-Kogan, DA; VandenBerg, SR; Berger, MS; James, CD,期刊：Cancer research, 页码：10034-10039 , 文章类型： Article，,卷期：2008年68-24] In this study, we investigated the precursor and active forms 01 a p53 small-molecule inhibitor for their effects on temozolomide (TMZ) antitumor activity against glioblastoma (GBM), using both in vitro and in vivo exper... Negative Regulation of AKT Activation by BRCA1 [作者：Xiang, T; Ohashi, A; Huang, YP; Pandita, TK; Ludwig, T; Powell, SN; Yang, Q,期刊：Cancer research, 页码：10040-10044 , 文章类型： Article，,卷期：2008年68-24] The breast cancer susceptibility gene 1 (BRCA1) plays a key role in mammary tumorigenesis. However, the reasons why silencing the Brca1 gene leads to tumorigenesis are not clearly understood. We report here that BRCA1 de... Racial Disparity in Breast Cancer and Functional Germ Line Mutation in Galectin-3 (rs4644): A Pilot Study [作者：Balan, V; Nangia-Makker, P; Schwartz, AG; Jung, YS; Tait, L; Hogan, V; Raz, T; Wang, Y; Yang, ZQ; Wu, GS; Guo, YJ; Li, HX; Abrams, L; Couch, FJ; Lingle, WL; Lloyd, RV; Ethier, SP; Tainsky, MA; Raz, A,期刊：Cancer research, 页码：10045-10050 , 文章类型： Article，,卷期：2008年68-24] For reasons largely unknown, Caucasian women are at a significantly higher risk of developing breast cancer than Asian women. Over a decade ago, mutations in BRCA1/2 were identified as genetic risk factors; however, the ... Cancer Stem Cells Are Enriched in the Side Population Cells in a Mouse Model of Glioma [作者：Harris, MA; Yang, H; Low, BE; Mukherje, J; Guha, A; Bronson, RT; Shultz, LD; Israel, MA; Yun, K,期刊：Cancer research, 页码：10051-10059 , 文章类型： Article，,卷期：2008年68-24] The recent identification of cancer stem cells (CSCs) in multiple human cancers provides a new inroad to understanding tumorigenesis at the cellular level. CSCs are defined by their characteristics of self-renewal, multi... The Innate Immune Receptor Nod1 Protects the Intestine from Inflammation-induced Tumorigenesis [作者：Chen, GY; Shaw, MH; Redondo, G; Nunez, G,期刊：Cancer research, 页码：10060-10067 , 文章类型： Article，,卷期：2008年68-24] There is growing evidence that the host innate immune system has a critical role in regulating carcinogenesis, but the specific receptors involved and the importance of their interaction with commensal bacteria need to b... Heparanase Augments Epidermal Growth Factor Receptor Phosphorylation: Correlation with Head and Neck Tumor Progression [作者：Cohen-Kaplan, V; Doweck, I; Naroditsky, I; Vlodavsky, I; Ilan, N,期刊：Cancer research, 页码：10077-10085 , 文章类型： Article，,卷期：2008年68-24] Heparanase is an endoglycosidase that specifically cleaves heparan sulfate side chains, a class of glycosaminoglycans abundantly present in the extracellular matrix and on the cell surface. Heparanase activity is strongl... Genetic Variants in Apoptosis and Immunoregulation-Related Genes Are Associated with Risk of Chronic Lymphocytic Leukemia [作者：Enjuanes, A; Benavente, Y; Bosch, F; Martin-Guerrero, I; Colomer, D; Perez-Alvarez, S; Reina, O; Ardanaz, MT; Jares, P; Garcia-Orad, A; Pujana, MA; Montserrat, E; de Sanjose, S; Campo, E,期刊：Cancer research, 页码：10178-10186 , 文章类型： Article，,卷期：2008年68-24] To identify low-penetrance susceptibility alleles for chronic lymphocytic leukemia (CLL), we performed a case-control study genotyping 768 single-nucleotide polymorphisms (SNP) in 692 cases of CLL and 738 controls. We in... Phospholipase C gamma 1 Is Required for Metastasis Development and Progression [作者：Sala, G; Dituri, F; Raimondi, C; Previdi, S; Maffucci, T; Mazzoletti, M; Rossi, C; Iezzi, M; Lattanzio, R; Piantelli, M; Iacobelli, S; Broggini, M; Falasca, M,期刊：Cancer research, 页码：10187-10196 , 文章类型： Article，,卷期：2008年68-24] Cell motility and invasion play an essential role in the development of metastasis. Evidence suggests that the enzyme phospholipase C gamma 1 (PLC gamma 1) may be involved in tumor progression and possibly development of... Altered Detoxification Status and Increased Resistance to Oxidative Stress by K-Ras Transformation [作者：Recktenwald, CV; Kellner, R; Lichtenfels, R; Seliger, B,期刊：Cancer research, 页码：10086-10093 , 文章类型： Article，,卷期：2008年68-24] Mutated K-ras is frequently found in human malignancies and plays a key role in many signal transduction processes resulting in an altered gene and/or protein expression pattern. Proteins controlled by a constitutive act... p53-Responsive MicroRNAs 192 and 215 Are Capable of Inducing Cell Cycle Arrest [作者：Braun, CJ; Zhang, X; Savelyeva, I; Wolff, S; Moll, UM; Schepeler, T; Orntoft, TF; Andersen, CL; Dobbelstein, M,期刊：Cancer research, 页码：10094-10104 , 文章类型： Article，,卷期：2008年68-24] microRNAs provide a novel layer of regulation for gene expression by interfering with the stability and/or translation of specific target mRNAs. Overall levels of microRNTAs are frequently down-regulated in cancer cells,... Molecular Mechanisms of Patupilone Resistance [作者：Mozzetti, S; Iantomasi, R; De Maria, I; Prislei, S; Mariani, M; Camperchioli, A; Bartollino, S; Gallo, D; Scambia, G; Ferlini, C,期刊：Cancer research, 页码：10197-10204 , 文章类型： Article，,卷期：2008年68-24] Patupilone is an epothilone in advanced clinical development that has shown promising efficacy in heavily pretreated patients. This study aimed at characterizing the mechanisms of patupilone activity in resistant patient... Coordinated Regulation of Cell Cycle Transcripts by p53-inducible microRNAs, miR-192 and miR-215 [作者：Georges, SA; Biery, MC; Kim, SY; Schelter, JM; Guo, J; Chang, AN; Jackson, AL; Carleton, MO; Linsley, PS; Cleary, MA; Chau, BN,期刊：Cancer research, 页码：10105-10112 , 文章类型： Article，,卷期：2008年68-24] Cell cycle arrest in response to DNA damage is an important antitumorigenic mechanism. MicroRNAs (miRNAs) were recently shown to play key regulatory roles in cell cycle progression. For example, miR-34a is induced in res...