- ONYX-411, a conditionally replicative oncolytic adenovirus, induces cell death in anaplastic thyroid carcinoma cell lines and suppresses the growth of xenograft tumors in nude mice
[作者:Reddi, HV; Madde, P; Reichert-Eberhardt, AJ; Galanis, EC; Copland, JA; McIver, B; Grebe, SKG; Eberhardt, NL,期刊:Cancer gene therapy, 页码:750-757 , 文章类型: Article,,卷期:2008年15-11]
- Anaplastic thyroid carcinoma (ATC) is the most aggressive thyroid cancer variant, accounting for 1-2% of all cases, but 33% of deaths, and exhibiting an average life expectancy of 5 months. ATC is largely unresponsive to...
- Adenovirus-mediated gene transfer of interleukin-23 shows prophylactic but not therapeutic antitumor effects
[作者:Jin, HT; Youn, JI; Choi, SY; Seo, SH; Park, SH; Song, MY; Yang, SH; Sung, YC,期刊:Cancer gene therapy, 页码:693-702 , 文章类型: Article,,卷期:2008年15-11]
- A novel cytokine interleukin (IL)-23 bears a structural and functional resemblance to IL-12. A recombinant adenovirus expressing IL-23N220L (recombinant replication-defective adenovirus (rAd)/IL-23N220L) that selectively...
- Enhanced delivery efficiency of recombinant adenovirus into tumor and mesenchymal stem cells by a novel PTD
[作者:Youn, JI; Park, SH; Jin, HT; Lee, CG; Seo, SH; Song, MY; Lee, CW; Sung, YC,期刊:Cancer gene therapy, 页码:703-712 , 文章类型: Article,,卷期:2008年15-11]
- Protein transduction domains (PTDs) are small peptides that facilitate the transduction of large molecules such as polyproteins, DNA and viruses into a eukaryotic cell. Here, we demonstrated that a novel PTD (HP4) derive...
- Development of recombinant adeno-associated virus and adenovirus cocktail system for efficient hTERTC27 polypeptide-mediated cancer gene therapy
[作者:Gao, Y; Ng, SSM; Chau, DHW; Yao, H; Yang, C; Man, K; Huang, PT; Huang, C; Huang, JJ; Kung, HF; Lin, MC,期刊:Cancer gene therapy, 页码:723-732 , 文章类型: Article,,卷期:2008年15-11]
- The low in vivo transduction efficiency of recombinant adeno-associated virus (rAAV) and the undesirably strong immunogenicity of adenovirus (rAdv) have limited their clinical utilization in cancer gene therapy. We have ...
- Molecular analysis of human cancer cells infected by an oncolytic HSV-1 reveals multiple upregulated cellular genes and a role for SOCS1 in virus replication
[作者:Mahller, YY; Sakthivel, B; Baird, WH; Aronow, BJ; Hsu, YH; Cripe, TP; Mehrian-Shai, R,期刊:Cancer gene therapy, 页码:733-741 , 文章类型: Article,,卷期:2008年15-11]
- Oncolytic herpes simplex viruses (oHSVs) are promising anticancer therapeutics. We sought to characterize the functional genomic response of human cancer cells to oHSV infection using G207, an oHSV previously evaluated i...
- Polyethylenimine-mediated in vivo gene transfer of a transmembrane superantigen fusion construct inhibits B16 murine melanoma growth
[作者:Jeudy, G; Salvadori, F; Chauffert, B; Solary, E; Vabres, P; Chluba, J,期刊:Cancer gene therapy, 页码:742-749 , 文章类型: Article,,卷期:2008年15-11]
- Immunotherapy has been proposed as a therapeutic strategy in advanced-stage melanomas in which other therapeutic options have little effect. The Staphylococcus enterotoxin A (SEA) has been used to stimulate an antitumora...
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