- E1A, E1B double-restricted replicative adenovirus at low dose greatly augments tumor-specific suicide gene therapy for gallbladder cancer
[作者:Fukuda, K; Abei, M; Ugai, H; Kawashima, R; Seo, E; Wakayama, M; Murata, T; Endo, S; Hamada, H; Hyodo, I; Yokoyama, KK,期刊:Cancer gene therapy, 页码:126-136 , 文章类型: Article,,卷期:2009年16-2]
- Combination therapy with replicative oncolytic viruses is a recent topic in innovative cancer therapy, but few studies have examined the efficacy of oncolytic adenovirus plus replication-deficient adenovirus carrying a s...
- Validation of tissue-specific promoter-driven tumor-targeting trans-splicing ribozyme system as a multifunctional cancer gene therapy device in vivo
[作者:Song, MS; Jeong, JS; Ban, G; Lee, JH; Won, YS; Cho, KS; Kim, IH; Lee, SW,期刊:Cancer gene therapy, 页码:113-125 , 文章类型: Article,,卷期:2009年16-2]
- A trans-splicing ribozyme that can specifically reprogram human telomerase reverse transcriptase ( hTERT) RNA was previously suggested as a useful tool for tumor-targeted gene therapy. In this study, we applied transcrip...
- PET imaging of heat-inducible suicide gene expression in mice bearing head and neck squamous cell carcinoma xenografts
[作者:Parry, JJ; Sharma, V; Andrews, R; Moros, EG; Piwnica-Worms, D; Rogers, BE,期刊:Cancer gene therapy, 页码:161-170 , 文章类型: Article,,卷期:2009年16-2]
- The ability to achieve tumor selective expression of therapeutic genes is an area that needs improvement for cancer gene therapy to be successful. One approach to address this is through the use of promoters that can be ...
- Loss of T cell-mediated antitumor immunity after construct-specific downregulation of retrovirally encoded T-cell receptor expression in vivo
[作者:Rubinstein, MP; Salem, ML; Kadima, AN; Nguyen, CL; Gillanders, WE; Nishimura, MI; Cole, DJ,期刊:Cancer gene therapy, 页码:171-183 , 文章类型: Article,,卷期:2009年16-2]
- Adoptive T-cell therapy is clinically efficacious in the treatment of select cancers. However, it is often difficult to obtain adequate numbers of tumor-specific T cells for therapy. One method for overcoming this limita...
- Growth inhibition of an established A431 xenograft tumor by a full-length anti-EGFR antibody following gene delivery by AAV
[作者:Ho, DT; Wykoff-Clary, S; Gross, CS; Schneider, D; Jin, F; Kretschmer, PJ; Hermiston, TW,期刊:Cancer gene therapy, 页码:184-194 , 文章类型: Article,,卷期:2009年16-2]
- Therapeutic monoclonal antibodies continue to achieve clinical success for the treatment of many different diseases, particularly cancer. However, the production and purification of antibodies continues to be a time and ...
- Transcriptional silencing of ETS-1 efficiently suppresses angiogenesis of pancreatic cancer
[作者:Lefter, LP; Dima, S; Sunamura, M; Furukawa, T; Sato, Y; Abe, M; Chivu, M; Popescu, I; Horii, A,期刊:Cancer gene therapy, 页码:137-148 , 文章类型: Article,,卷期:2009年16-2]
- In this study, we addressed the hypothesis that transcriptional suppression of erythroblastosis virus E26 oncogene homolog 1 (ETS-1) is an efficient therapeutic approach to pancreatic adenocarcinoma by investigating the ...
- TNF-alpha and the IFN-gamma-inducible protein 10 (IP-10/CXCL-10) delivered by parvoviral vectors act in synergy to induce antitumor effects in mouse glioblastoma
[作者:Enderlin, M; Kleinmann, EV; Struyf, S; Buracchi, C; Vecchi, A; Kinscherf, R; Kiessling, F; Paschek, S; Sozzani, S; Rommelaere, J; Cornelis, JJ; Van Damme, J; Dinsart, C,期刊:Cancer gene therapy, 页码:149-160 , 文章类型: Article,,卷期:2009年16-2]
- Interferon-gamma-inducible protein 10 is a potent chemoattractant for natural killer cells and activated T lymphocytes. It also displays angiostatic properties and some antitumor activity. Tumor necrosis factor-alpha (TN...
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