- Structural insights into the multifunctional protein VP3 of birnaviruses
[作者:Casanas, A; Navarro, A; Ferrer-Orta, C; Gonzalez, D; Rodriguez, JF; Verdaguer, N,期刊:Structure, 页码:29-37 , 文章类型: Article,,卷期:2008年16-1]
- Infectious bursal disease virus (IBDV), a member of the Birnaviridae family, is the causative agent of one of the most harmful poultry diseases. The IBDV genome encodes five mature proteins; of these, the multifunctional...
- Structure of the yeast tRNA m7G methylation complex
[作者:Leulliot, N; Chaillet, M; Durand, D; Ulryck, N; Blondeau, K; van Tilbeurgh, H,期刊:Structure, 页码:52-61 , 文章类型: Article,,卷期:2008年16-1]
- Loss of N7-methylguanosine (m7G) modification is involved in the recently discovered rapid tRNA degradation pathway. In yeast, this modification is catalyzed by the heterodimeric complex composed of a catalytic subunit T...
- Structures of the human orotidine-5 '-monophosphate decarboxylase support a covalent mechanism and provide a framework for drug design
[作者:Wiftmann, JG; Heinrich, D; Gasow, K; Frey, A; Diederichsen, U; Rudolph, MG,期刊:Structure, 页码:82-92 , 文章类型: Article,,卷期:2008年16-1]
- UMP synthase (UMPS) catalyzes the last two steps of de novo pyrimidine nucleotide synthesis and is a potential cancer drug target. The C-terminal domain of UMPS is orotidine-5'-monophosphate decarboxylase (OMPD), a cofac...
- Extended polypeptide linkers establish the spatial architecture of a pyruvate dehydrogenase multienzyme complex
[作者:Lengyel, JS; Stott, KM; Wu, XW; Brooks, BR; Balbo, A; Schuck, P; Perham, RN; Subramaniam, S; Milne, JLS,期刊:Structure, 页码:93-103 , 文章类型: Article,,卷期:2008年16-1]
- Icosahedral pyruvate dehydrogenase (PDH) enzyme complexes are molecular machines consisting of a central E2 core decorated by a shell of peripheral enzymes (E1 and E3) found localized at a distance of similar to 75-90 an...
- Structures of the human pyruvate dehydrogenase complex cores: A highly conserved catalytic center with flexible N-terminal domains
[作者:Yu, XK; Hiromasa, Y; Tsen, H; Stoops, JK; Roche, TE; Zhou, ZH,期刊:Structure, 页码:104-114 , 文章类型: Article,,卷期:2008年16-1]
- Dihydrolipoyl acetyltransferase (E2) is the central component of pyruvate dehydrogenase complex (PDC), which converts pyruvate to acetyl-CoA. Structural comparison by cryo-electron microscopy (cryo-EM) of the human full-...
- Structure of the human protein kinase MPSK1 reveals an atypical activation loop architecture
[作者:Eswaran, J; Bernad, A; Ligos, JM; Guinea, B; Debreczeni, JE; Sobott, F; Parker, SA; Najmanovich, R; Turk, BE; Knapp, S,期刊:Structure, 页码:115-124 , 文章类型: Article,,卷期:2008年16-1]
- The activation segment of protein kinases is structurally highly conserved and central to regulation of kinase activation. Here we report an atypical activation segment architecture in human MPSK1 comprising a beta sheet...
- Roles of structure and structural dynamics in the antibody recognition of the allergen proteins: An NMR study on Blomia tropicalis major allergen
[作者:Naik, MT; Chang, CF; Kuo, IC; Kung, CCH; Yi, FC; Chua, KY; Huang, TH,期刊:Structure, 页码:125-136 , 文章类型: Article,,卷期:2008年16-1]
- Blo t 5 is the major allergen from Blomia tropicalis mites and shows strong IgE reactivity with up to 90% of asthmatic and rhinitis patients' sera. The NMR solution structure of Blo t 5 comprises three long alpha helices...
- Vibrid cholerae toxin-coregulated pilus structure analyzed by hydrogen/deuterium exchange mass spectrometry
[作者:Li, J; Lim, MS; Li, S; Brock, M; Pique, ME; Woods, VL; Craig, L,期刊:Structure, 页码:137-148 , 文章类型: Article,,卷期:2008年16-1]
- The bacterial pathogen Vibrio cholerae uses toxin-coregulated pili (TCIP) to colonize the human intestine, causing the severe diarrheal disease cholera. TCP are long, thin, flexible homopolymers of the TcpA subunit that ...
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