个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共16条记录   Solution NMR structure of a designed metalloprotein and complementary molecular dynamics refinement [作者：Calhoun, JR; Liu, W; Spiegel, K; Dal Peraro, M; Klein, ML; Valentine, KG; Wand, AJ; DeGrado, WF,期刊：Structure, 页码：210-215 , 文章类型： Article，,卷期：2008年16-2] We report the solution NMR structure of a designed dimetal-binding protein, di-Zn(II) DFsc, along with a secondary refinement step employing molecular dynamics techniques. Calculation of the initial NMR structural ensemb... Structural basis for EGF receptor inhibition by the therapeutic antibody IMC-11F8 [作者：Li, S; Kussie, P; Ferguson, KM,期刊：Structure, 页码：216-227 , 文章类型： Article，,卷期：2008年16-2] Therapeutic anticancer strategies that target and inactivate the epidermal growth factor receptor (EGFR) are under intense study in the clinic. Here we describe the mechanism of EGFR inhibition by an antibody drug IMC-11... Structures of P-falciparum protein kinase 7 identify an activation motif and leads for inhibitor design [作者：Merckx, A; Echalier, A; Langford, K; Sicard, A; Langsley, G; Joore, J; Doerig, C; Noble, M; Enclicott, J,期刊：Structure, 页码：228-238 , 文章类型： Article，,卷期：2008年16-2] Malaria is a major threat to world health. The identification of parasite targets for drug development is a priority and parasitic protein kinases suggest themselves as suitable targets as many display profound structura... De novo high-resolution protein structure determination from sparse spin-labeling EPR data [作者：Alexander, N; Bortolus, M; Al-Mestarihi, A; Mchaourab, H; Meilerl, J,期刊：Structure, 页码：181-195 , 文章类型： Article，,卷期：2008年16-2] As many key proteins evade crystallization and remain too large for nuclear magnetic resonance spectroscopy, electron paramagnetic resonance (EPR) spectroscopy combined with site-directed spin labeling offers an alternat... Bifunctional NMN adenylyltransferase/ADP-ribose pyrophosphatase: Structure and function in bacterial NAD metabolism [作者：Huang, N; Sorci, L; Zhang, XJ; Brautigam, CA; Li, XQ; Raffaelli, N; Magni, G; Grishin, NV; Osterman, AL; Zhang, H,期刊：Structure, 页码：196-209 , 文章类型： Article，,卷期：2008年16-2] Bacterial NadM-Nudix is a bifunctional enzyme containing a nicotinamide mononucleotide (NMN) adenylyltransferase and an ADP-ribose (ADPR) pyrophosphatase domain. While most members of this enzyme family, such as that fro... Protein-template-directed synthesis across an acrolein-derived DNA adduct by yeast rev1 DNA polymerase [作者：Nair, DT; Johnson, RE; Prakash, L; Prakash, S; Aggarwal, AK,期刊：Structure, 页码：239-245 , 文章类型： Article，,卷期：2008年16-2] Acrolein is generated as the end product of lipid peroxidation and is also a ubiquitous environmental pollutant. Its reaction with the N-2 of guanine leads to a cyclic gamma-HOPdG adduct that presents a block to normal r... Insights into oncogenic mutations of plexin-B1 based on the solution structure of the rho GTPase binding domain [作者：Tong, Y; Hota, PK; Hamaneh, MB; Buck, M,期刊：Structure, 页码：246-258 , 文章类型： Article，,卷期：2008年16-2] The plexin family of transmembrane receptors are important for axon guidance, angiogenesis, but also in cancer. Recently, plexin-B1 somatic missense mutations were found in both primary tumors and metastases of breast an... Biochemical and structural studies of ASPP proteins reveal differential binding to p53, p63, and p73 [作者：Robinson, RA; Lu, X; Jones, EY; Siebold, C,期刊：Structure, 页码：259-268 , 文章类型： Article，,卷期：2008年16-2] ASPP1 and ASPP2 are activators of p53-dependent apoptosis, whereas iASPP is an inhibitor of p53. Binding assays showed differential binding for C-terminal domains of iASPP and ASPP2 to the core domains of p53 family memb... Funnel hunting in a rough terrain: Learning and discriminating native energy funnels [作者：London, N; Schueler-Furman, O,期刊：Structure, 页码：269-279 , 文章类型： Article，,卷期：2008年16-2] Protein folding and binding is commonly depicted as a search for the minimum energy conformation. Modeling of protein complex structures by RosettaDock often results in a set of low-energy conformations near the native s... Alanine-scanning mutagenesis defines a conserved energetic hotspot in the Ca-v alpha(1) AID-Ca-v beta interaction site that is critical for channel modulation [作者：Van Petegem, F; Duderstadt, KE; Clark, KA; Wang, M; Minor, DL,期刊：Structure, 页码：280-294 , 文章类型： Article，,卷期：2008年16-2] Voltage-gated calcium channels (Ca(v)s) are large, multisubunit complexes that control cellular calcium entry. Ca-v pore-forming (Ca-v alpha(1)) and cytoplasmic (Ca-v beta) subunits associate through a high-affinity inte... Protein structure fitting and refinement guided by cryo-EM density [作者：Topf, M; Lasker, K; Webb, B; Wolfson, H; Chiu, W; Sali, A,期刊：Structure, 页码：295-307 , 文章类型： Article，,卷期：2008年16-2] For many macromolecular assemblies, both a cryo-electron microscopy map and atomic structures of its component proteins are available. Here we describe a method for fitting and refining a component structure within its m... Accessory proteins stabilize the acceptor complex for synaptobrevin, the 1 : 1 syntaxin/SNAP-25 complex [作者：Weninger, K; Bowen, ME; Choi, UB; Chu, S; Brunger, AT,期刊：Structure, 页码：308-320 , 文章类型： Article，,卷期：2008年16-2] Syntaxin/SNAP-25 interactions precede assembly of the ternary SNARE complex that is essential for neurotransmitter release. This binary complex has been difficult to characterize by bulk methods because of the prevalence... Close correspondence between the motions from principal component analysis of multiple HIV-1 protease structures and elastic network modes [作者：Yang, L; Song, G; Carriquiry, A; Jernigan, RL,期刊：Structure, 页码：321-330 , 文章类型： Article，,卷期：2008年16-2] The large number of available HIV-1 protease structures provides a remarkable sampling of conformations of the different conformational states, which can be viewed as direct structural information about the dynamics of t... Structural insights into DNA lesion bypass [作者：Sung, P,期刊：Structure, 页码：161-162 , 文章类型： Editorial Material，,卷期：2008年16-2] A number of highly specialized DNA polymerases with the ability to replicate through DNA lesions have been identified. In this issue of Structure, Nair et al. show how one such polymerase, yeast Rev1, accomplishes the DN... A dynamic t-SNARE complex [作者：Rizo, J,期刊：Structure, 页码：163-165 , 文章类型： Editorial Material，,卷期：2008年16-2] Syntaxin-1/SNAP-25 heterodimers with 1:1 stoichiometry likely play a key role in neurotransmitter release but they have been difficult to characterize. In this issue of Structure, Weninger et al. present a beautiful sing... H2A.Z: View from the top [作者：Zlatanova, J; Thakar, A,期刊：Structure, 页码：166-179 , 文章类型： Review，,卷期：2008年16-2] For a couple of decades the chromatin field has endured undeserved neglect. Indeed, what could be so exciting about a monotonous repeating structure whose purpose in life was to package DNA? Chromatin glamour is triumpha...