- Colicin N binds to the periphery of its receptor and translocator, outer membrane protein F
[作者：Baboolal, TG; Conroy, MJ; Gill, K; Ridley, H; Visudtiphole, V; Bullough, PA; Lakey, JH,期刊：Structure, 页码：371-379 , 文章类型： Article，,卷期：2008年16-3]
- Colicins kill Escherichia coli after translocation across the outer membrane. Colicin N displays an unusually simple translocation pathway, using the outer membrane protein F (OmpF) as both receptor and translocator. Stu...
- Regulation of enzyme localization by polymerization: Polymer formation by the SAM domain of diacylglycerol kinase delta 1
[作者：Harada, BT; Knight, MJ; Imai, SI; Qiao, F; Ramachander, R; Sawaya, MR; Gingery, M; Sakane, F; Bowie, JU,期刊：Structure, 页码：380-387 , 文章类型： Article，,卷期：2008年16-3]
- The diacylglycerol kinase (DGK) enzymes function as regulators of intracellular signaling by altering the levels of the second messengers, diacylglycerol. and phosphatidic acid. The DGK delta and eta isozymes possess a c...
- Molecular basis for peroxisomal localization of tetrameric carbonyl reductase
[作者：Tanaka, N; Aoki, KI; Ishikura, S; Nagano, M; Imamura, Y; Hara, A; Nakamura, KT,期刊：Structure, 页码：388-397 , 文章类型： Article，,卷期：2008年16-3]
- Pig heart peroxisomal carbonyl reductase (PerCR) belongs to the short-chain dehydrogenase/reductase family, and its sequence comprises a C-terminal SRL tripeptide, which is a variant of the type 1 peroxisomal targeting s...
- Crystal structures of beta-neurexin 1 and beta-neurexin 2 ectodomains and dynamics of splice insertion sequence 4
[作者：Koehnke, J; Jin, X; Trbovic, N; Katsamba, PS; Brasch, J; AhIsen, G; Scheiffele, P; Honig, B; Palmer, AG; Shapiro, L,期刊：Structure, 页码：410-421 , 文章类型： Article，,卷期：2008年16-3]
- Presynaptic neurexins (NRXs) bind to postsynaptic neuroligins (NLs) to form Ca2+-dependent complexes that bridge neural synapses. beta-NRXs bind NLs through their LNS domains, which contain a single site of alternative s...
- Regulation of neurexin 1 beta tertiary structure and ligand binding through alternative splicing
[作者：Shen, KC; Kuczynska, DA; Wu, IJ; Murray, BH; Sheckler, LR; Rudenko, G,期刊：Structure, 页码：422-431 , 文章类型： Article，,卷期：2008年16-3]
- Neurexins and neuroligins play an essential role in synapse function, and their alterations are linked to autistic spectrum disorder. Interactions between neurexins and neuroligins regulate inhibitory and excitatory syna...
- Structure of the oligosaccharyl transferase complex at 12 angstrom resolution
[作者：Li, H; Chavan, M; Schindelin, H; Lennarz, WJ; Li, HL,期刊：Structure, 页码：432-440 , 文章类型： Article，,卷期：2008年16-3]
- Oligosaccharyl transferase (OT) catalyzes the transfer of a lipid-linked oligosaccharide to the nascent polypeptide emerging from the translocon. Currently, there is no structural information on the membrane-embedded OT ...
- De novo backbone trace of GroEL from single particle electron cryomicroscopy
[作者：Ludtke, SJ; Baker, ML; Chen, DH; Song, JL; Chuang, DT; Chiu, W,期刊：Structure, 页码：441-448 , 文章类型： Article，,卷期：2008年16-3]
- In this work, we employ single-particle electron cryo-microscopy (cryo-EM) to reconstruct GroEL to similar to 4 angstrom resolution with both D7 and C7 symmetry. Using a newly developed skeletonization algorithm and seco...
- Molecular basis of fibrin clot elasticity
[作者：Lim, BBC; Lee, EH; Sotomayor, M; Schulten, K,期刊：Structure, 页码：449-459 , 文章类型： Article，,卷期：2008年16-3]
- Blood clots must be stiff to stop hemorrhage yet elastic to buffer blood's shear forces. Upsetting this balance results in clot rupture and life-threatening thromboembolism. Fibrin, the main component of a blood clot, is...
- Mechanism of activation and inhibition of the HER4/ErbB4 kinase
[作者：Qiu, C; Tarrant, MK; Choi, SH; Sathyamurthy, A; Bose, R; Banjade, S; Pal, A; Bornmann, WG; Lemmon, MA; Cole, PA; Leahy, DJ,期刊：Structure, 页码：460-467 , 文章类型： Article，,卷期：2008年16-3]
- HER4/ErbB4 is a ubiquitously expressed member of the EGF/ErbB family of receptor tyrosine kinases that is essential for normal development of the heart, nervous system, and mammary gland. We report here crystal structure...
- Cryo-EM structure of the DNA-Dependent protein kinase catalytic subunit at subnanometer resolution reveals alpha helices and insight into DNA binding
[作者：Williams, DR; Lee, KJ; Shi, J; Chen, DJ; Stewart, PL,期刊：Structure, 页码：468-477 , 文章类型： Article，,卷期：2008年16-3]
- The DNA-dependent protein kinase catalytic subunit (DNA-PKcs) regulates the nonhomologous end joining pathway for repair of double-stranded DNA (dsDNA) breaks. Here, we present a 7 angstrom resolution structure of DNA-PK...
- Crystal structure of a full-length beta-catenin
[作者：Xing, Y; Takemaru, KI; Liu, J; Berndt, JD; Zheng, JJ; Moon, RT; Xu, WQ,期刊：Structure, 页码：478-487 , 文章类型： Article，,卷期：2008年16-3]
- beta-catenin plays essential roles in cell adhesion and Wnt signaling, while deregulation of beta-catenin is associated with multiple diseases including cancers. Here, we report the crystal structures of full-length zebr...
- A helical string of alternately connected three-helix bundles for the cell wall-associated adhesion protein Ebh from Staphylococcus aureus
[作者：Tanaka, Y; Sakamoto, S; Kuroda, M; Goda, S; Gao, YG; Tsumoto, K; Hiragi, Y; Yao, M; Watanabe, N; Ohta, T; Tanaka, I,期刊：Structure, 页码：488-496 , 文章类型： Article，,卷期：2008年16-3]
- The 1.1 MDa cell-wall-associated adhesion protein of staphylococci, Ebh, consists of several distinct regions, including a large central region with 52 imperfect repeats of 126 amino acid residues. We investigated the st...
- A trigger squeezed
[作者：Eigenbrot, C,期刊：Structure, 页码：332-334 , 文章类型： Editorial Material，,卷期：2008年16-3]
- Qiu et al. (2008) add new weight to the very highly detailed understanding of how extracellular ligand binding-induced dimerization of a receptor tyrosine kinase is first manifested inside the cell.
- DNA-PKcs at 7 angstrom: Insights for DNA repair
[作者：Shimazaki, N; Lieber, MR,期刊：Structure, 页码：334-336 , 文章类型： Editorial Material，,卷期：2008年16-3]
- In this issue of Structure, the Stewart laboratory and their collaborators have provided a markedly improved cryo-EM reconstruction of DNA-PKcs (Williams et al., 2008). The new level of detail heightens interest in integ...
- Terminal regions of beta-catenin come into view
[作者：Gottardi, CJ; Peifer, M,期刊：Structure, 页码：336-338 , 文章类型： Editorial Material，,卷期：2008年16-3]
- beta-catenin is remarkably multifunctional, acting in adhesion, cytoskeletal regulation, and Wnt signaling. In this issue, Xing et al. (2008) present the full-length structure of beta-catenin, providing a clearer picture...
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