- The molecular mechanism of toxin-induced conformational changes in a potassium channel: Relation to C-type inactivation
[作者:Zachariae, U; Schneider, R; Velisetty, P; Lange, A; Seeliger, D; Wacker, SJ; Karimi-Nejad, Y; Vriend, G; Becker, S; Pongs, O; Baldus, M; de Groot, BL,期刊:Structure, 页码:747-754 , 文章类型: Article,,卷期:2008年16-5]
- Recently, a solid-state NMR study revealed that scorpion toxin binding leads to conformational changes in the selectivity filter of potassium channels. The exact nature of the conformational changes, however, remained el...
- Multiple conformations of E-coli Hsp90 in solution: Insights into the conformational dynamics of Hsp90
[作者:Krukenberg, KA; Forster, F; Rice, LM; Sali, A; Agard, DA,期刊:Structure, 页码:755-765 , 文章类型: Article,,卷期:2008年16-5]
- Hsp90, an essential eukaryotic chaperone, depends upon its intrinsic ATPase activity for function. Crystal structures of the bacterial Hsp90 homolog, HtpG, and the yeast Hsp90 reveal large domain rearrangements between t...
- An intersubunit active site between supercoiled parallel beta helices in the trimeric tailspike endorhamnosidase of Shigella flexneri phage Sf6
[作者:Muller, JJ; Barbirz, S; Heinle, K; Freiberg, A; Seckler, R; Heinemann, U,期刊:Structure, 页码:766-775 , 文章类型: Article,,卷期:2008年16-5]
- Sf6 belongs to the Podoviridae family of temperate bacteriophages that infect gram-negative bacteria by insertion of their double-stranded DNA. They attach to their hosts specifically via their tailspike proteins. The 1....
- Partitivirus structure reveals a 120-subunit, helix-rich capsid with distinctive surface arches formed by quasisymmetric coat-protein dimers
[作者:Ochoa, WF; Havens, WM; Sinkovits, RS; Nibert, ML; Ghabrial, SA; Baker, TS,期刊:Structure, 页码:776-786 , 文章类型: Article,,卷期:2008年16-5]
- Two distinct partitiviruses, Penicillium stoloniferurn viruses S and F, can be isolated from the fungus Penicillium stoloniferum. The bisegmented dsRNA genomes of these viruses are separately packaged in icosahedral caps...
- Crystal structure of NFAT bound to the HIV-1 LTR tandem kappa B enhancer element
[作者:Bates, DL; Barthel, KKB; Wu, YQ; Kalhor, R; Stroud, JC; Giffin, MJ; Chen, L,期刊:Structure, 页码:684-694 , 文章类型: Article,,卷期:2008年16-5]
- The host factor, nuclear factor of activated T-cells (NFAT), regulates the transcription and replication of HIV-1. Here, we have determined the crystal structure of the DNA binding domain of NFAT bound to the HIV-1 long ...
- X-ray scattering study of activated Arp2/3 complex with bound actin-WCA
[作者:Boczkowska, M; Rebowski, G; Petoukhov, MV; Hayes, DB; Svergun, DI; Dominguez, R,期刊:Structure, 页码:695-704 , 文章类型: Article,,卷期:2008年16-5]
- Previous structures of Arp2/3 complex, determined in the absence of a nucleation-promoting factor and actin, reveal its inactive conformation. The study of the activated structure has been hampered by uncontrollable poly...
- Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site
[作者:Rushe, M; Silvian, L; Bixler, S; Chen, LL; Cheung, A; Bowes, S; Cuervo, H; Berkowitz, S; Zheng, T; Guckian, K; Pellegrini, M; Lugovskoy, A,期刊:Structure, 页码:798-808 , 文章类型: Article,,卷期:2008年16-5]
- The phosphorylation Of I kappa B by the IKK complex targets it for degradation and releases NF-kappa B for translocation into the nucleus to initiate the inflammatory response, cell proliferation, or cell differentiation...
- Crystal structures of human saposins C and D: Implications for lipid recognition and membrane interactions
[作者:Rossmann, M; Schultz-Heienbrok, R; Behlke, J; Remmel, N; Alings, C; Sandhoff, K; Saenger, W; Maier, T,期刊:Structure, 页码:809-817 , 文章类型: Article,,卷期:2008年16-5]
- Human saposins are essential proteins required for degradation of sphingolipids and lipid antigen presentation. Despite the conserved structural organization of saposins, their distinct modes of interaction with biologic...
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