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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共18条记录   A specific cholesterol binding site is established by the 2.8 angstrom structure of the human beta(2)-adrenergic receptor [作者：Hanson, MA; Cherezov, V; Griffith, MT; Roth, CB; Jaakola, VP; Chien, EYT; Velasquez, J; Kuhn, P; Stevens, RC,期刊：Structure, 页码：897-905 , 文章类型： Article，,卷期：2008年16-6] The role of cholesterol in eukaryotic membrane protein function has been attributed primarily to an influence on membrane fluidity and curvature. We present the 2.8 angstrom resolution crystal structure of a thermally st... Importin-beta: Structural and dynamic determinants of a molecular spring [作者：Zachariae, U; Grubmuller, H,期刊：Structure, 页码：906-915 , 文章类型： Article，,卷期：2008年16-6] The beta-karyopherin/RanGTP system constitutes the largest known family of cellular cargo transporters. The flexibility of the karyopherin transport receptors is the key to their versatility in binding cargoes of differe... A functional proline switch in cytochrome P450(cam) [作者：OuYang, B; Pochapsky, SS; Dang, M; Pochapsky, TC,期刊：Structure, 页码：916-923 , 文章类型： Article，,卷期：2008年16-6] The two-protein complex between putidaredoxin (Pdx) and cytochrome P450(cam) (CYP101) is the catalytically competent species for camphor hydroxylation by CYP101. We detected a conformational change in CYP101 upon binding... A model for the solution structure of the rod arrestin tetramer [作者：Hanson, SM; Dawson, ES; Francis, DJ; Van Eps, N; Klug, CS; Hubbell, WL; Meiler, J; Gurevich, VV,期刊：Structure, 页码：924-934 , 文章类型： Article，,卷期：2008年16-6] Visual rod arrestin has the ability to self-associate at physiological concentrations. We previously demonstrated that only monomeric arrestin can bind the receptor and that the arrestin tetramer in solution differs from... DNA poised for release in bacteriophage phi 29 [作者：Tang, JH; Olson, N; Jardine, PJ; Girimes, S; Anderson, DL; Baker, TS,期刊：Structure, 页码：935-943 , 文章类型： Article，,卷期：2008年16-6] We present here the first asymmetric, three-dimensional reconstruction of a tailed dsDNA virus, the mature bacteriophage phi 29, at subnanometer resolution. This structure reveals the rich detail of the asymmetric int... Solution structure and sugar-binding mechanism of mouse latrophilin-1 RBL: a 7TM receptor-attached lectin-like domain [作者：Vakonakis, I; Langenhan, T; Promel, S; Russ, A; Cambell, ID,期刊：Structure, 页码：944-953 , 文章类型： Article，,卷期：2008年16-6] Latrophilin-1 (Lat-1), a target receptor for alpha-Latrotoxin, is a putative G protein-coupled receptor implicated in synaptic function. The extracellular portion of Lat-1 contains a rhamnose binding lectin (RBL)like dom... Integrin conformational regulation: Uncoupling extension/tail separation from changes in the head region by a multiresolution approach [作者：Rocco, M; Rosano, C; Weisel, JW; Horita, DA; Hantgan, RR,期刊：Structure, 页码：954-964 , 文章类型： Article，,卷期：2008年16-6] Integrin-dependent adhesion and signaling are regulated by conformational changes whose details remain controversial. Crystallography revealed bent shapes for resting and primed integrin ectodomains, whereas large, ligan... Solution structure of Alg13: The sugar donor subunit of a yeast N-acetylglucosamine transferase [作者：Wang, X; Weldeghiorghis, T; Zhang, GF; Imperiali, B; Prestegard, JH,期刊：Structure, 页码：965-975 , 文章类型： Article，,卷期：2008年16-6] The solution structure of Alg13, the glycosyl donor-binding domain of an important bipartite glycosyltransferase in the yeast Saccharomyces cerevisiae, is presented. This glycosyltransferase is unusual in that it is acti... Structure of a copper pump suggests a regulatory role for its metal-binding domain [作者：Wu, CC; Rice, WJ; Stokes, DL,期刊：Structure, 页码：976-985 , 文章类型： Article，,卷期：2008年16-6] P-type ATPases play an important role in Cu homeostasis, which provides sufficient Cu for metalloenzyme biosynthesis but prevents oxidative damage of free Cu to the cell. The P-IB group of P-type ATPases includes ATP-dep... Preparation of multimilligram quantities of large, linear DNA molecules for structural studies [作者：Muecke, M; Samuels, M; Davey, M; Jeruzalmi, D,期刊：Structure, 页码：837-841 , 文章类型： Article，,卷期：2008年16-6] We describe a method for preparing large, linear DNA molecules in amounts that are suitable for structural studies. The procedure employs self-primed DNA amplification on a starting molecule that consists of the sequence... The structure of a two-disulfide intermediate assists in elucidating the oxidative folding pathway of a cyclic cystine knot protein [作者：Cemazar, M; Joshi, A; Daly, NL; Mark, AE; Craik, DJ,期刊：Structure, 页码：842-851 , 文章类型： Article，,卷期：2008年16-6] We have determined the three-dimensional structure of a two-disulfide intermediate (CyS8-CYS20, Cys(14)-Cys(26)) on the oxidative folding pathway of the cyclotide MCoTI-II. Cyclotides have a range of bioactivities and, b... Asymmetric EM reveals new twists in phage phi 29 biology [作者：Duda, RL; Conway, JF,期刊：Structure, 页码：831-832 , 文章类型： Editorial Material，,卷期：2008年16-6] Cu+-ATPases brake system [作者：Arguello, JM; Gonzalez-Guerrero, M,期刊：Structure, 页码：833-834 , 文章类型： Editorial Material，,卷期：2008年16-6] Insights into the kinetochore [作者：Asbury, CL; Davis, TN,期刊：Structure, 页码：834-836 , 文章类型： Editorial Material，,卷期：2008年16-6] Structural analysis reveals conformational plasticity in the recognition of RNA 3 ' ends by the human La protein [作者：Kotik-Kogan, O; Valentine, ER; Sanfelice, D; Conte, MR; Curry, S,期刊：Structure, 页码：852-862 , 文章类型： Article，,卷期：2008年16-6] The eukaryotic La protein recognizes the 3' poly(U) sequences of nascent RNA polymerase III transcripts to assist folding and maturation. The 3' ends of such RNAs are bound by the N-terminal domain of La (LaNTD). We have... Picometer-scale conformational heterogeneity separates functional from nonfunctional states of a photoreceptor protein [作者：Coureux, PD; Fan, ZP; Stojanoff, V; Genick, UK,期刊：Structure, 页码：863-872 , 文章类型： Article，,卷期：2008年16-6] Protein structural fluctuations occur over a wide spatial scale, ranging from minute, picometer-scale displacements, to large, interdomain motions and partial unfolding. While large-scale protein structural changes and t...