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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共19条记录   A lipidic-sponge phase screen for membrane protein crystallization [作者：Wohri, AB; Johansson, LC; Wadsten-Hindrichsen, P; Wahlgren, WY; Fischer, G; Horsefield, R; Katona, G; Nyblom, M; Oberg, F; Young, G; Cogdell, RJ; Fraser, NJ; Engstrom, S; Neutze, R,期刊：Structure, 页码：1003-1009 , 文章类型： Article，,卷期：2008年16-7] A major current deficit in structural biology is the lack of high-resolution structures of eukaryotic membrane proteins, many of which are key drug targets for the treatment of disease. Numerous eukaryotic membrane prote... Ab initio folding of proteins with all-atom discrete molecular dynamics [作者：Ding, F; Tsao, D; Nie, HF; Dokholyan, NV,期刊：Structure, 页码：1010-1018 , 文章类型： Article，,卷期：2008年16-7] Discrete molecular dynamics (DMD) is a rapid sampling method used in protein folding and aggregation studies. Until now, DMD was used to perform simulations of simplified protein models in conjunction with structure-base... Structural basis for dimerization in DNA recognition by Gal4 [作者：Hong, MQ; Fitzgerald, MX; Harper, S; Luo, C; Speicher, DW; Marmorstein, R,期刊：Structure, 页码：1019-1026 , 文章类型： Article，,卷期：2008年16-7] Gal4 is a Zn(2)Cys(6) binuclear cluster containing transcription factor that binds DNA as a homodimer and can activate transcription by interacting with the mutant Gal11P protein. Although structures have been reported o... Crystal structure of the outer membrane protein OpdK from Pseudomonas aeruginosa [作者：Biswas, S; Mohammad, MM; Movileanu, L; van den Berg, B,期刊：Structure, 页码：1027-1035 , 文章类型： Article，,卷期：2008年16-7] In Gram-negative bacteria that do not have porins, most water-soluble and small molecules are taken up by substrate-specific channels belonging to the OprD family. We report here the X-ray crystal structure of OpdK, an O... Analysis of the Staphylococcus aureus DgkB structure reveals a common catalytic mechanism for the soluble diacylglycerol kinases [作者：Miller, DJ; Jerga, A; Rock, CO; White, SW,期刊：Structure, 页码：1036-1046 , 文章类型： Article，,卷期：2008年16-7] Soluble diacylglycerol (DAG) kinases function as regulators of diacylglycerol metabolism in cell signaling and intermediary metabolism. We report the structure of a DAG kinase, DgkB from Staphyiococcus aureus, both as th... Beyond induced-fit receptor-ligand interactions: Structural changes that can significantly extend bond lifetimes [作者：Nilsson, LM; Thomas, WE; Sokurenko, EV; Vogel, V,期刊：Structure, 页码：1047-1058 , 文章类型： Article，,卷期：2008年16-7] While the lifetime of conventional receptor-ligand interactions is shortened by tensile mechanical force, some recently discovered interactions, termed catch bonds, can be strengthened by force. Motivated by the search f... Multiple-site trimethylation of ribosomal protein L11 by the PrmA methyltransferase [作者：Demirci, H; Gregory, ST; Dahlberg, AE; Jogl, G,期刊：Structure, 页码：1059-1066 , 文章类型： Article，,卷期：2008年16-7] Ribosomal protein L11 is a universally conserved component of the large subunit, and plays a significant role during initiation, elongation, and termination of protein synthesis. In Escherichia coli, the lysine methyltra... The interplay of functional tuning, drug resistance, and thermodynamic stability in the evolution of the M2 proton channel from the influenza a virus [作者：Stouffer, AL; Ma, CL; Cristian, L; Ohigashi, Y; Lamb, RA; Lear, JD; Pinto, LH; DeGrado, WF,期刊：Structure, 页码：1067-1076 , 文章类型： Article，,卷期：2008年16-7] We explore the interplay between amino acid sequence, thermodynamic stability, and functional fitness in the M2 proton channel of influenza A virus. Electrophysiological measurements show that drug-resistant mutations ha... Structural basis for the recognition of histone H4 by the histone-chaperone RbAp46 [作者：Murzina, NV; Pei, XY; Zhang, W; Sparkes, M; Vicente-Garcia, J; Pratap, JV; McLaughlin, SH; Ben-Shahar, TR; Verreault, A; Luisi, BF; Laue, ED,期刊：Structure, 页码：1077-1085 , 文章类型： Article，,卷期：2008年16-7] RbAp46 and RbAp48 (pRB-associated proteins p46 and p48, also known as RBBP7 and RBBP4, respectively) are highly homologous histone chaperones that play key roles in establishing and maintaining chromatin structure. We re... Structure of the parathyroid hormone receptor C terminus bound to the G-protein dimer G beta(1)gamma(2) [作者：Johnston, CA; Kimple, AJ; Giguere, PM; Siderovski, DP,期刊：Structure, 页码：1086-1094 , 文章类型： Article，,卷期：2008年16-7] A critical role of the G beta gamma dimer in heterotrimeric G-protein signaling is to facilitate the engagement and activation of the G alpha subunit by cell-surface G-protein-coupled receptors. However, high-resolution ... The tRNA-induced conformational activation of human mitochondrial phenylalanyl-tRNA synthetase [作者：Klipcan, L; Levin, I; Kessler, N; Moor, N; Finarov, I; Safro, M,期刊：Structure, 页码：1095-1104 , 文章类型： Article，,卷期：2008年16-7] All class II aminoacyl-tRNA synthetases (aaRSs) are known to be active as functional homodimers, homotetramers, or heterotetramers. However, multimeric organization is not a prerequisite for phenylalanylation activity, a... Starch catabolism by a prominent human gut symbiont is directed by the recognition of amylose helices [作者：Koropatkin, NM; Martens, EC; Gordon, JI; Smith, TJ,期刊：Structure, 页码：1105-1115 , 文章类型： Article，,卷期：2008年16-7] The human gut microbiota performs functions that are not encoded in our Homo sapiens genome, including the processing of otherwise undigestible dietary polysaccharides. Defining the structures of proteins involved in the... The crystal structure of the Ran-Nup153ZnF2 complex: a general Ran docking site at the nuclear pore complex [作者：Schrader, N; Koerner, C; Koessmeier, K; Bangert, JA; Wittinghofer, A; Stoll, R; Vetter, IR,期刊：Structure, 页码：1116-1125 , 文章类型： Article，,卷期：2008年16-7] Nucleoporin (Nup) 153 is a highly mobile, multifunctional, and essential nuclear pore protein. It contains four zinc finger motifs that are thought to be crucial for the regulation of transport-receptor/cargo interaction... Single copies of Sec61 and TRAP associate with a nontranslating mammalian ribosome [作者：Menetret, JF; Hegde, RS; Aguiar, M; Gygi, SP; Park, E; Rapoport, TA; Akey, CW,期刊：Structure, 页码：1126-1137 , 文章类型： Article，,卷期：2008年16-7] During cotranslational protein translocation, the ribosome associates with a membrane channel, formed by the Sec61 complex, and recruits the translocon-associated protein complex (TRAP). Here we report the structure of a... The SNARE complex from yeast is partially unstructured on the membrane [作者：Su, ZL; Ishitsuka, Y; Ha, T; Shin, YK,期刊：Structure, 页码：1138-1146 , 文章类型： Article，,卷期：2008年16-7] Molecular recognition between cognate SNAREs leads to the formation of a four-helix bundle, which facilitates vesicle docking and membrane fusion. For a SNARE system involved in trafficking in yeast, target membrane (t-)... Force generation in kinesin hinges on cover-neck bundle formation (vol 16, pg 62, 2008) [作者：Hwang, W; Lang, MJ; Karplus, M,期刊：Structure, 页码：1147-1147 , 文章类型： Correction，,卷期：2008年16-7]