- A GBD uncovered: the FHOD1 N terminus is formin'
[作者:Baarlink, C; Grosse, R,期刊:Structure, 页码:1287-1288 , 文章类型: Editorial Material,,卷期:2008年16-9]
- In this issue, Schulte et al. (2008) present the structure of the N-terminal region of human Diaphanous-related formin FHOD1, providing new insights into the differential molecular mechanisms of formin regulation and act...
- A SIR-tain acetyl complex is caught by a sulfur trap
[作者:Sauve, AA,期刊:Structure, 页码:1289-1292 , 文章类型: Editorial Material,,卷期:2008年16-9]
- In this issue, Hawse et al. (2008) provide additional insight into the mechanistic properties of sirtuin enzymes by describing the structure of a thio-imidate in the active site of Thermatoga maritima Sir2, which strengt...
- RapA: Completing the transcription cycle?
[作者:Nechaev, S; Severinov, K,期刊:Structure, 页码:1294-1295 , 文章类型: Editorial Material,,卷期:2008年16-9]
- In this issue of Structure, Shaw et al. (2008) report a crystal structure of the Escherichia coli RapA protein, the only bacterial member of the SWI/SNF2 family (Lewis et al., 1992; Bork and Koonin, 1993). The structure ...
- PACemakers of proteasome core particle assembly
[作者:Ramos, PC; Dohmen, RJ,期刊:Structure, 页码:1296-1304 , 文章类型: Review,,卷期:2008年16-9]
- The 26S proteasome mediates ubiquitin-dependent proteolysis in eukaryotic cells. A number of studies including very recent ones have revealed that assembly of its 20S catalytic core particle is an ordered process that in...
- Accurate NMR structures through minimization of an extended hybrid energy
[作者:Nilges, M; Bernard, A; Bardiaux, B; Malliavin, T; Habeck, M; Rieping, W,期刊:Structure, 页码:1305-1312 , 文章类型: Article,,卷期:2008年16-9]
- The use of generous distance bounds has been the hallmark of NMR structure determination. However, bounds necessitate the estimation of data quality before the calculation, reduce the information content, introduce human...
- The human formin FHOD1 contains a bipartite structure of FH3 and GTPase-binding domains required for activation
[作者:Schulte, A; Stolp, B; Schonichen, A; Pylypenko, O; Rak, A; Fackler, OT; Geyer, M,期刊:Structure, 页码:1313-1323 , 文章类型: Article,,卷期:2008年16-9]
- Formins induce the nucleation and polymerization of unbranched actin filaments. They share three homology domains required for profilin binding, actin polymerization, and regulation. Diaphanous-related formins (DRFs) are...
- Structure of the PduU shell protein from the Pdu microcompartment of Salmonella
[作者:Crowley, CS; Sawaya, MR; Bobik, TA; Yeates, TO,期刊:Structure, 页码:1324-1332 , 文章类型: Article,,卷期:2008年16-9]
- The Pdu microcompartment is a proteinaceous, subcellular structure that serves as an organelle for the metabolism of 1,2-propanediol in Salmonella enterica. It encapsulates several related enzymes within a shell composed...
- Structure and disassembly of filaments formed by the ESCRT-III subunit Vps24
[作者:Ghazi-Tabatabai, S; Saksena, S; Short, JM; Pobbati, AV; Veprintsev, DB; Crowther, RA; Emr, SD; Egelman, EH; Williams, RL,期刊:Structure, 页码:1345-1356 , 文章类型: Article,,卷期:2008年16-9]
- The ESCRT machinery mediates sorting of ubiquitinated transmembrane proteins to lysosomes via multivesicular bodies (MVBs) and also has roles in cytokinesis and viral budding. The ESCRT-III subunits are metastable monome...
- The complete VS ribozyme in solution studied by small-angle X-ray scattering
[作者:Lipfert, J; Ouellet, J; Norman, DG; Doniach, S; Lilley, DMJ,期刊:Structure, 页码:1357-1367 , 文章类型: Article,,卷期:2008年16-9]
- We have used small-angle X-ray solution scattering to obtain ab initio shape reconstructions of the complete VS ribozyme. The ribozyme occupies an electron density envelope with an irregular shape, into which helical sec...
- Structural insights into intermediate steps in the Sir2 deacetylation reaction
[作者:Hawse, WF; Hoff, KG; Fatkins, DG; Daines, A; Zubkova, OV; Schramm, VL; Zheng, W; Wolberger, C,期刊:Structure, 页码:1368-1377 , 文章类型: Article,,卷期:2008年16-9]
- Sirtuin enzymes comprise a unique class of NAD(+)-dependent protein deacetylases. Although structures of many sirtuin complexes have been determined, structural resolution of intermediate chemical steps are needed to und...
- Insights into the mode of action of a putative zinc transporter CzrB in Thermus thermophilus
[作者:Cherezov, V; Hofer, N; Szebeny, DME; Kolaj, O; Wall, JG; Gillilan, R; Srinivasan, V; Jaroniec, CP; Caffrey, M,期刊:Structure, 页码:1378-1388 , 文章类型: Article,,卷期:2008年16-9]
- The crystal structures of the cytoplasmic domain of the putative zinc transporter CzrB in the apo and zinc-bound forms reported herein are consistent with the protein functioning in vivo as a homodimer. NMR, X-ray scatte...
- Bacteriophage lambda stabilization by auxiliary protein gpD: Timing, location, and mechanism of attachment determined by cryo-EM
[作者:Lander, GC; Evilevitch, A; Jeembaeva, M; Potter, CS; Carragher, B; Johnson, JE,期刊:Structure, 页码:1399-1406 , 文章类型: Article,,卷期:2008年16-9]
- We report the cryo-EM structure of bacteriophage lambda and the mechanism for stabilizing the 20-angstrom-thick capsid containing the dsDNA genome. The crystal structure of the HK97 bacteriophage capsid fits most of the ...
- Structural basis for DNA recognition by FoxO1 and its regulation by posttranslational modification
[作者:Brent, MM; Anand, R; Marmorstein, R,期刊:Structure, 页码:1407-1416 , 文章类型: Article,,卷期:2008年16-9]
- FoxO transcription factors regulate the transcription of genes that control metabolism, cellular proliferation, stress tolerance, and possibly life span. A number of posttranslational modifications within the forkhead DN...
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