- Regulation of endothelial cell cytoskeletal reorganization by a secreted frizzled-related protein-1 and frizzled 4-and frizzled 7-dependent pathway
[作者:Dufourcq, P; Leroux, L; Ezan, J; Descamps, B; Lamaziere, JMD; Costet, P; Basoni, C; Moreau, C; Deutsch, U; Couffinhal, T; Duplaa, C,期刊:American Journal of Pathology, 页码:37-49 , 文章类型: Article,,卷期:2008年172-1]
- Consistent with findings of Wnt pathway members involved in vascular cells, a role for Wnt/Frizzled signaling has recently emerged in vascular cell development. Among the few Wnt family members implicated in vessel forma...
- Macrophage migration inhibitory factor is up-regulated in human first-trimester placenta stimulated by soluble antigen of Toxoplasma gondii, resulting in increased monocyte adhesion on villous explants
[作者:Ferro, EAV; Mineo, JR; Letta, F; Bechi, N; Romagnoli, R; Silva, DA; Sorda, G; Bevilacqua, E; Paulesu, LR,期刊:American Journal of Pathology, 页码:50-58 , 文章类型: Article,,卷期:2008年172-1]
- Considering the potential role of macrophage migration inhibitory factor (MIF) in the inflammation process in placenta when infected by pathogens, we investigated the production of this cytokine in chorionic villous expl...
- Role of nicotinic and estrogen signaling during experimental acute and chronic bladder inflammation
[作者:Martinez-Ferrer, M; Iturregui, JM; Uwamariya, C; Starkman, J; Sharif-Afshar, AR; Suzuki, K; Visedsindh, W; Matusik, RJ; Dmochowski, RR; Bhowmick, NA,期刊:American Journal of Pathology, 页码:59-67 , 文章类型: Article,,卷期:2008年172-1]
- Inflammation is a physiological process that characterizes many bladder diseases. We hypothesized that nicotinic and estrogen signaling could down regulate bladder inflammation. Cyclophosphamide was used to induce acute ...
- Severe intrauterine growth restriction pregnancies have increased placental endoglin levels - Hypoxic regulation via transforming growth factor-beta 3
[作者:Yinon, Y; Nevo, O; Xu, J; Many, A; Rolfo, A; Todros, T; Post, M; Caniggia, I,期刊:American Journal of Pathology, 页码:77-85 , 文章类型: Article,,卷期:2008年172-1]
- Endoglin, a co-receptor for transforming growth factor (TGF)-beta(1) and -beta(3) is expressed in the human placenta and plays an important role in the pathogenesis of preeclampsia. Because preeclampsia is associated wit...
- Acute modulations in permeability barrier function regulate epidermal cornification - Role of caspase-14 and the protease activated receptor type 2
[作者:Demerjian, M; Hachem, JP; Tschachler, E; Denecker, G; Declercq, W; Vandenabeele, P; Mauro, T; Hupe, M; Crumrine, D; Roelandt, T; Houben, E; Elias, PM; Feingold, KR,期刊:American Journal of Pathology, 页码:86-97 , 文章类型: Article,,卷期:2008年172-1]
- Stratum corneum comprises corneocytes, derived from outer stratum granulosum during terminal differentiation, embedded in a lipid-enriched extracellular matrix, secreted from epidermal lamellar bodies. Permeability barri...
- Clinical and lmmunopathologic alterations in rhesus macaques affected with globoid cell leukodystrophy
[作者:Borda, JT; Alvarez, X; Mohan, M; Ratterree, MS; Phillippi-Falkenstein, K; Lackner, AA; Bunnell, BA,期刊:American Journal of Pathology, 页码:98-111 , 文章类型: Article,,卷期:2008年172-1]
- Globoid cell leukodystrophy, or Krabbe's disease, is a severe disorder of the central and peripheral nervous system caused by the absence of galactocerebrosidase (GALC) activity. Herein, we describe the clinical, neuropa...
- Mechanism of glycosaminoglycan-mediated bone and joint disease - Implications for the mucopolysaccharidoses and other connective tissue diseases
[作者:Simonaro, CM; D'Angelo, M; He, XX; Eliyahu, E; Shtraizent, N; Haskins, ME; Schuchman, EH,期刊:American Journal of Pathology, 页码:112-122 , 文章类型: Article,,卷期:2008年172-1]
- We have previously shown that glycosaminoglycan (GAG) storage in animal models of the mucopolysaccharidoses (NIPS) leads to inflammation and apoptosis within cartilage. We have now extended these findings to synovial tis...
- Analysis of tau phosphorylation and truncation in a mouse model of human tauopathy
[作者:Delobel, P; Lavenir, I; Fraser, G; Ingram, E; Holzer, M; Ghetti, B; Spillantini, MG; Crowther, RA; Goedert, M,期刊:American Journal of Pathology, 页码:123-131 , 文章类型: Article,,卷期:2008年172-1]
- Recent evidence has suggested that truncation of tau protein at the caspase cleavage site D421 precedes hyperphosphorylation and may be necessary for the assembly of tau into filaments in Alzheimer's disease and other ta...
- Sex-defined T-cell responses to cardiac self determine differential outcomes of murine dilated cardiomyopathy
[作者:Jane-Wit, D; Altuntas, CZ; Monti, J; Johnson, JM; Forsthuber, TG; Tuohy, VK,期刊:American Journal of Pathology, 页码:11-21 , 文章类型: Article,,卷期:2008年172-1]
- idiopathic dilated cardiomyopathy (DCM) is a disease of putative autoimmune origin that kills males at a twofold to threefold greater frequency than females. The reasons underlying these differential outcomes may be rela...
- Both TLR2 and TLR4 are required for the effective immune response in Staphylococcus aureus-induced experimental murine brain abscess
[作者:Stenzel, W; Soltek, S; Sanchez-Ruiz, M; Akira, S; Miletic, H; Schluter, D; Deckert, M,期刊:American Journal of Pathology, 页码:132-145 , 文章类型: Article,,卷期:2008年172-1]
- Toll-like receptors (TLRs) play central roles in the innate reaction to bacterial products and transmit specific immune responses against these pathogens. TLRs are expressed on numerous cell types, including innate immun...
- Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis
[作者:Tzartos, JS; Friese, MA; Craner, MJ; Palace, J; Newcombe, J; Esiri, MM; Fugger, L,期刊:American Journal of Pathology, 页码:146-155 , 文章类型: Article,,卷期:2008年172-1]
- Recent findings in the animal model for multiple sclerosis (MS), experimental autoimmune encephalomyelitis, implicate a novel CD4(+) T-cell subset (T(H)17), characterized by the secretion of interleukin-17 (IL-17), in di...
- Exaggerated neointima formation in human C-reactive protein transgenic mice is IgG Fc receptor type I (Fc gamma RI)-dependent
[作者:Xing, DQ; Hage, FG; Chen, YF; McCrory, MA; Feng, WG; Skibinski, GA; Majid-Hassan, E; Oparil, S; Szalai, AJ,期刊:American Journal of Pathology, 页码:22-30 , 文章类型: Article,,卷期:2008年172-1]
- Neointima formation after vascular injury is exaggerated in ovariectomized (OVX) human C-reactive protein transgenic mice (CRPtg) compared to nontransgenic mice (NTG). We tested the hypothesis that this CRP-mediated exac...
- Microbial IgA protease removes IgA immune complexes from mouse glomeruli In Vivo: Potential therapy for IgA nephropathy
[作者:Lamm, ME; Emancipator, SN; Robinson, JK; Yamashita, M; Fujioka, H; Qiu, JZ; Plaut, AG,期刊:American Journal of Pathology, 页码:31-36 , 文章类型: Article,,卷期:2008年172-1]
- The hallmark of IgA nephropathy (IgAN), the most common form of glomerulonephritis, is the presence of mesangial deposits containing IgA, specifically the IgA1 subclass, as the most prominent component. The deposited IgA...
- A critical role for Rac1 in tumor progression of human colorectal adenocarcinoma cells
[作者:Espina, C; Cespedes, MV; Garcia-Cabezas, MA; del Pulgar, MG; Boluda, A; Oroz, LG; Cejas, P; Nistal, M; Mangues, R; Lacal, JC,期刊:American Journal of Pathology, 页码:156-166 , 文章类型: Article,,卷期:2008年172-1]
- Colorectal adenocarcinoma is the second cause of cancer mortality in developed countries. Rac1 is a member of the family of Rho GTPases that regulates many intracellular signaling pathways, including those involved in tu...
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