- Co-Existent Pseudoxanthoma Elasticum and Vitamin K-Dependent Coagulation Factor Deficiency Compound Heterozygosity for Mutations in the GGCX Gene
[作者：Li, QL; Schurgers, LJ; Smith, ACM; Tsokos, M; Uitto, J; Cowen, EW,期刊：American Journal of Pathology, 页码：534-540 , 文章类型： Article，,卷期：2009年174-2]
- Pseudoxanthoma elasticum (PXE) is a multisystem disorder characterized by ectopic mineralization of connective tissues with primary manifestations in the skin, eyes, and cardiovascular system. The classic forms of PXE, a...
- Fn14-TRAIL, a Chimeric Intercellular Signal Exchanger, Attenuates Experimental Autoimmune Encephalomyelitis
[作者：Razmara, M; Hilliard, B; Ziarani, AK; Murali, R; Yellayi, S; Ghazanfar, M; Chen, YH; Tykocinski, ML,期刊：American Journal of Pathology, 页码：460-474 , 文章类型： Article，,卷期：2009年174-2]
- Hallmarks of the pathogenesis of autoimmune encephalomyelitis include perivascular infiltration of inflammatory cells into the central nervous system, multifocal demyelination in the brain and spinal cord, and focal neur...
- Molecular Classification of Rhabdomyosarcoma-Genotypic and Phenotypic Determinants of Diagnosis A Report from the Children's Oncology Group
[作者：Davicioni, E; Anderson, MJ; Finckenstein, FG; Lynch, JC; Qualman, SJ; Shimada, H; Schofield, DE; Buckley, JD; Meyer, WH; Sorensen, PHB; Triche, TJ,期刊：American Journal of Pathology, 页码：550-564 , 文章类型： Article，,卷期：2009年174-2]
- Rhabdomyosarcoma (RMS) in children occurs as two major histological subtypes, embryonal (ERMS) and alveolar (ARMS). ERMS is associated with an 11p15.5 loss of heterozygosity (LOH) and may be confused with nonmyogenic, no...
- IL-4/IL-13-Dependent Alternative Activation of Macrophages but Not Microglial Cells Is Associated with Uncontrolled Cerebral Cryptococcosis
[作者：Stenzel, W; Muller, U; Kohler, G; Heppner, FL; Blessing, M; McKenzie, ANJ; Brombacher, F; Albert, G,期刊：American Journal of Pathology, 页码：486-496 , 文章类型： Article，,卷期：2009年174-2]
- Both interleukin (IL)-4- and IL-13-dependent Th2-mediated immune mechanisms exacerbate murine Cryplococcus neoformans-induced bronchopulmonary disease. To study the roles of IL-4 and IL-13 in cerebral cryptococcosis, IL-...
- Proteome-Wide Identification of Novel Binding Partners to the Oncogenic Fusion Gene Protein, NPM-ALK, using Tandem Affinity Purification and Mass Spectrometry
[作者：Wu, F; Wang, P; Young, LC; Lai, R; Li, L,期刊：American Journal of Pathology, 页码：361-370 , 文章类型： Article，,卷期：2009年174-2]
- Nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), an oncogenic fusion gene protein that is characteristically found in a subset of anaplastic large cell lymphomas, promotes tumorigenesis through its functional and phys...
- Profiling Bladder Cancer Organ Site-Specific Metastasis Identifies LAMC2 as a Novel Biomarker of Hematogenous Dissemination
[作者：Smith, SC; Nicholson, B; Nitz, M; Frierson, HF; Smolkin, M; Hampton, G; El-Rifai, W; Theodorescu, D,期刊：American Journal of Pathology, 页码：371-379 , 文章类型： Article，,卷期：2009年174-2]
- Little is known about which genes mediate metastasis in bladder cancer, which accounts for much of the mortality of this disease. We used human bladder cancer cell lines to develop models of two clinically common metasta...
- Senescent Keratinocytes Die by Autophagic Programmed Cell Death
[作者：Gosselin, K; Deruy, E; Martien, S; Vercamer, C; Bouali, F; Dujardin, T; Slomianny, C; Houel-Renault, L; Chelli, F; De Launoit, Y; Abbadie, C,期刊：American Journal of Pathology, 页码：423-435 , 文章类型： Article，,卷期：2009年174-2]
- Normal cells reach senescence after a specific time and number of divisions, leading ultimately to cell death. Although escape from this fate may be a requisite step in neoplastic transformation, the mechanisms governing...
- FoxP3(+) Regulatory T Cells Suppress Early Stages of Granuloma Formation but Have Little Impact on Sarcoidosis Lesions
[作者：Taflin, C; Miyara, M; Nochy, D; Valeyre, D; Naccache, JM; Altare, F; Salek-Peyron, P; Badoual, C; Bruneval, P; Haroche, J; Mathian, A; Amoura, Z; Hill, G; Gorochov, G,期刊：American Journal of Pathology, 页码：497-508 , 文章类型： Article，,卷期：2009年174-2]
- Sarcoidosis is characterized by a disproportionate Th1 granulomatous immune response in involved organs. It is also associated with both peripheral and intratissular regulatory T cell (Treg) expansion. These cells exhibi...
- Staphylococcus aureus Beta-Toxin Induces Lung Injury through Syndecan-1
[作者：Hayashida, A; Bartlett, AH; Foster, TJ; Park, PW,期刊：American Journal of Pathology, 页码：509-518 , 文章类型： Article，,卷期：2009年174-2]
- In pneumonia caused by the bacterium Staphylococcus aureus, the intense inflammatory response that is triggered by this infection can lead to the development of lung injury. Little is known, however, about the impact of ...
- Activin-Like Kinase 5 (ALK5) Mediates Abnormal Proliferation of Vascular Smooth Muscle Cells from Patients with Familial Pulmonary Arterial Hypertension and Is Involved in the Progression of Experimental Pulmonary Arterial Hypertension Induced by Monocrotaline
[作者：Thomas, M; Docx, C; Holmes, AM; Beach, S; Duggan, N; England, K; Leblanc, C; Lebret, C; Schindler, F; Raza, F; Walker, C; Crosby, A; Davies, RJ; Morrell, NW; Budd, DC,期刊：American Journal of Pathology, 页码：380-389 , 文章类型： Article，,卷期：2009年174-2]
- Mutations in the gene for the transforming growth factor (TGF)-beta superfamily receptor, bone morphogenetic protein receptor II, underlie heritable forms of pulmonary arterial hypertension (PAH). Aberrant signaling via ...
- Role of Stem Cell Factor and Bone Marrow-Derived Fibroblasts in Airway Remodeling
[作者：Dolgachev, VA; Ullenbruch, MR; Lukacs, NW; Phan, SH,期刊：American Journal of Pathology, 页码：390-400 , 文章类型： Article，,卷期：2009年174-2]
- Recent evidence suggests that bone marrow-derived fibroblasts are involved in air-way remodeling in asthma, but the role and mechanism of recruitment of these fibroblasts remains unclear. Stem cell factor (SCF), a key fa...
- Non-Muscle Myosin IIA Differentially Regulates Intestinal Epithelial Cell Restitution and Matrix Invasion
[作者：Babbin, BA; Koch, S; Bachar, M; Conti, MA; Parkos, CA; Adelstein, RS; Nusrat, A; Ivanov, AI,期刊：American Journal of Pathology, 页码：436-448 , 文章类型： Article，,卷期：2009年174-2]
- Epithelial cell motility is critical for self-rejuvenation of normal intestinal mucosa, wound repair, and cancer metastasis. This process is regulated by the reorganization of the F-actin cytoskeleton, which is driven by...
- A Protein Kinase C delta-Dependent Protein Kinase D Pathway Modulates ERK1/2 and JNK1/2 Phosphorylation and Bim-Associated Apoptosis by Asbestos
[作者：Buder-Hoffmann, SA; Shukla, A; Barrett, TF; MacPherson, MB; Lounsbury, KM; Mossman, BT,期刊：American Journal of Pathology, 页码：449-459 , 文章类型： Article，,卷期：2009年174-2]
- Inhalation of asbestos and oxidant-generating pollutants causes injury and compensatory proliferation of lung epithelium, but the signaling mechanisms that lead to these responses are unclear. We hypothesized that a prot...
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