- Antibody therapeutics, antibody engineering, and the merits of protein stability
[作者:Demarest, SJ; Glaser, SM,期刊:Current Opinion in Drug Discovery & Development, 页码:675-687 , 文章类型: Review,,卷期:2008年11-5]
Antibodies are highly soluble, multidomain proteins that are well suited for biopharmaceutical development; however, engineering antibodies to perform novel activities or to have enhanced clinical utility can have a d...
- Unraveling the details of prion (con)formation(s): Recent advances by mass spectrometry
[作者:Principe, S; Maras, B; Schinina, ME; Pocchiari, M; Cardone, F,期刊:Current Opinion in Drug Discovery & Development, 页码:697-707 , 文章类型: Review,,卷期:2008年11-5]
Transmissible spongiform encephalopathies (TSEs), or prion diseases, are neurodegenerative disorders affecting both humans and animals. TSEs are caused by the infectious agent 'prion', which is poorly characterized an...
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