- Synthesis, anti-inflammatory evaluation and docking studies of some new fluorinated fused quinazolines
[作者:Balakumar, C; Lamba, P; Kishore, DP; Narayana, BL; Rao, KV; Rajwinder, K; Rao, AR; Shireesha, B; Narsaiah, B,期刊:European Journal of Medicinal Chemistry, 页码:4904-4913 , 文章类型: Article,,卷期:2010年45-11]
- A series of novel 8/10-trifluoromethyl-substituted-imidazo[1,2-c] quinazolines have been synthesized and evaluated in vivo (rat paw edema) for their anti-inflammatory activity and in silico (docking studies) to recognize...
- Preparation of new polycyclic compounds derived from benzofurans and furochromones. An approach to novel 1,2,3-thia-, and selena-diazolofurochromones of anticipated antitumor activities
[作者:Atta, SMS; Farrag, DS; Sweed, AMK; Abdel-Rahman, AH,期刊:European Journal of Medicinal Chemistry, 页码:4920-4927 , 文章类型: Article,,卷期:2010年45-11]
- Base catalyzed condensation of enaminoketones (3a,b) with malononitrile yields the respective 7-imino-5[2(substituted)prop-1-enyl]furochromene-6-carbonitriles (4a-d) according to the nature of base used. Compounds (3a, b...
- Effect of milrinone analogues on intracellular calcium increase in single living H9C2 cardiac cells
[作者:Pietrangelo, T; Giampietro, L; De Filippis, B; La Rovere, R; Fulle, S; Amoroso, R,期刊:European Journal of Medicinal Chemistry, 页码:4928-4933 , 文章类型: Article,,卷期:2010年45-11]
- The synthesis of milrinone analogues where the 4-pyridyl moiety was replaced by an ester or amide group is reported. Only amide derivatives are able to support intracellular calcium influx following chemical depolarizati...
- Structure-based optimization and biological evaluation of human 20 alpha-hydroxysteroid dehydrogenase (AKR1C1) salicylic acid-based inhibitors
[作者:El-Kabbani, O; Scammells, PJ; Day, T; Dhagat, U; Endo, S; Matsunaga, T; Soda, M; Hara, A,期刊:European Journal of Medicinal Chemistry, 页码:5309-5317 , 文章类型: Article,,卷期:2010年45-11]
- The tertiary structure of the Leu308Val mutant of human 20 alpha-hydroxysteroid dehydrogenase (AKR1C1) in complex with the inhibitor 3,5-dichlorosalicylic acid (DCL) has been determined. Structures and kinetic properties...
- A V-shaped ligand 2,6-bis(2-benzimidazolyl)pyridine and its picrate Mn(II) complex: Synthesis, crystal structure and DNA-binding properties
[作者:Wu, HL; Huang, XC; Yuan, JK; Kou, F; Jia, F; Liu, B; Wang, KT,期刊:European Journal of Medicinal Chemistry, 页码:5324-5330 , 文章类型: Article,,卷期:2010年45-11]
- A V-shaped ligand 2,6-bis(2-benzimidazolyl)pyridine (bbp) and its picrate Mn(II) complex have been synthesized and characterized by elemental analysis, molecular conductivities, H-1 NMR, IR, UV-vis spectra and X-ray sing...
- Synthesis and Identification of a new class of antileukemic agents containing 2-(arylcarboxamide)-(S)-6-amino-4,5,6,7-tetrahydrobenzo[d]thiazole
[作者:Prasanna, DS; Kavitha, CV; Vinaya, K; Ranganatha, SR; Raghavan, SC; Rangappa, KS,期刊:European Journal of Medicinal Chemistry, 页码:5331-5336 , 文章类型: Article,,卷期:2010年45-11]
- Recently we have reported the effect of (S)-6-aryl urea/thiourea substituted-2-amino-4,5,6,7-tetrahydrobenzo[d]thiazole derivatives as potent anti-leukemic agents. To elucidate further the Structure Activity Relationship...
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