- Functional reconstitution of human eukaryotic translation initiation factor 3 (eIF3)
[作者:Sun, CM; Todorovic, A; Querol-Audi, J; Bai, Y; Villa, N; Snyder, M; Ashchyan, J; Lewis, CS; Hartland, A; Gradia, S; Fraser, CS; Doudna, JA; Nogales, E; Cate, JHD,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20473-20478 , 文章类型: Article,,卷期:2011年108-51]
- Protein fate in higher eukaryotes is controlled by three complexes that share conserved architectural elements: the proteasome, COP9 signalosome, and eukaryotic translation initiation factor 3 (eIF3). Here we reconstitut...
- Targeted knock-down of a structurally atypical zebrafish 12S-lipoxygenase leads to severe impairment of embryonic development
[作者:Haas, U; Raschperger, E; Hamberg, M; Samuelsson, B; Tryggvason, K; Haeggstrom, JZ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20479-20484 , 文章类型: Article,,卷期:2011年108-51]
- Lipoxygenases (LO) are a class of dioxygenases, which form hydroperoxy, hydroxy, and epoxy derivatives of arachidonic acid with distinct positional and stereochemical configurations. In man, there are two known types of ...
- Multiple molecular architectures of the eye lens chaperone alpha B-crystallin elucidated by a triple hybrid approach
[作者:Braun, N; Zacharias, M; Peschek, J; Kastenmuller, A; Zou, J; Hanzlik, M; Haslbeck, M; Rappsilber, J; Buchner, J; Weinkauf, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20491-20496 , 文章类型: Article,,卷期:2011年108-51]
- The molecular chaperone alpha B-crystallin, the major player in maintaining the transparency of the eye lens, prevents stress-damaged and aging lens proteins from aggregation. In nonlenticular cells, it is involved in va...
- The genomic binding sites of a noncoding RNA
[作者:Simon, MD; Wang, CI; Kharchenko, PV; West, JA; Chapman, BA; Alekseyenko, AA; Borowsky, ML; Kuroda, MI; Kingston, RE,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20497-20502 , 文章类型: Article,,卷期:2011年108-51]
- Long noncoding RNAs (lncRNAs) have important regulatory roles and can function at the level of chromatin. To determine where lncRNAs bind to chromatin, we developed capture hybridization analysis of RNA targets (CHART), ...
- Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8
[作者:Jo, Y; Lee, PCW; Sguigna, PV; DeBose-Boyd, RA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20503-20508 , 文章类型: Article,,卷期:2011年108-51]
- Accumulation of sterols in membranes of the endoplasmic reticulum (ER) leads to the accelerated ubiquitination and proteasomal degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase, a rate-limiting enzyme in syn...
- Contribution of a mutational bias in hepatitis C virus replication to the genetic barrier in the development of drug resistance
[作者:Powdrill, MH; Tchesnokov, EP; Kozak, RA; Russell, RS; Martin, R; Svarovskaia, ES; Mo, HM; Kouyos, RD; Gotte, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20509-20513 , 文章类型: Article,,卷期:2011年108-51]
- The development of resistance to direct-acting antivirals (DAAs) targeting the hepatitis C virus (HCV) can compromise therapy. However, mechanisms that determine prevalence and frequency of resistance-conferring mutation...
- Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases
[作者:Giardina, G; Montioli, R; Gianni, S; Cellini, B; Paiardini, A; Voltattorni, CB; Cutruzzola, F,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20514-20519 , 文章类型: Article,,卷期:2011年108-51]
- DOPA decarboxylase, the dimeric enzyme responsible for the synthesis of neurotransmitters dopamine and serotonin, is involved in severe neurological diseases such as Parkinson disease, schizophrenia, and depression. Bind...
- Specific recognition of linear ubiquitin chains by the Npl4 zinc finger (NZF) domain of the HOIL-1L subunit of the linear ubiquitin chain assembly complex
[作者:Sato, Y; Fujita, H; Yoshikawa, A; Yamashita, M; Yamagata, A; Kaiser, SE; Iwai, K; Fukai, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20520-20525 , 文章类型: Article,,卷期:2011年108-51]
- The linear ubiquitin chain assembly complex (LUBAC) is a key nuclear factor-kappa B (NF-kappa B) pathway component that produces linear polyubiquitin chains. The HOIL-1L subunit of LUBAC has been shown to bind linear cha...
- Antitumor activity from antigen-specific CD8 T cells generated in vivo from genetically engineered human hematopoietic stem cells
[作者:Vatakis, DN; Koya, RC; Nixon, CC; Wei, L; Kim, SG; Avancena, P; Bristol, G; Baltimore, D; Kohn, DB; Ribas, A; Radu, CG; Galic, Z; Zack, JA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E1408-E1416 , 文章类型: Article,,卷期:2011年108-51]
- The goal of cancer immunotherapy is the generation of an effective, stable, and self-renewing antitumor T-cell population. One such approach involves the use of high-affinity cancer-specific T-cell receptors in gene-ther...
- Fitness costs limit influenza A virus hemagglutinin glycosylation as an immune evasion strategy
[作者:Das, SR; Hensley, SE; David, A; Schmidt, L; Gibbs, JS; Puigbo, P; Ince, WL; Bennink, JR; Yewdell, JW,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E1417-E1422 , 文章类型: Article,,卷期:2011年108-51]
- Here, we address the question of why the influenza A virus hemagglutinin (HA) does not escape immunity by hyperglycosylation. Uniquely among dozens of monoclonal antibodies specific for A/Puerto Rico/8/34, escape from H2...
- Complex microbiome underlying secondary and primary metabolism in the tunicate-Prochloron symbiosis
[作者:Donia, MS; Fricke, WF; Partensky, F; Cox, J; Elshahawi, SI; White, JR; Phillippy, AM; Schatz, MC; Piel, J; Haygood, MG; Ravel, J; Schmidt, EW,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E1423-E1432 , 文章类型: Article,,卷期:2011年108-51]
- The relationship between tunicates and the uncultivated cyanobacterium Prochloron didemni has long provided a model symbiosis. P. didemni is required for survival of animals such as Lissoclinum patella and also makes sec...
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