- CC Chemokine Receptor 5 (CCR5) Desensitization CYCLING RECEPTORS ACCUMULATE IN THE TRANS-GOLGI NETWORK
[作者:Escola, JM; Kuenzi, G; Gaertner, H; Foti, M; Hartley, O,期刊:Journal of Biological Chemistry, 页码:41772-41780 , 文章类型: Article,,卷期:2010年285-53]
- CC chemokine receptor 5 (CCR5), the major HIV coreceptor, is a G protein-coupled receptor (GPCR) involved in cell activation and migration in response to chemokines. Blockade of CCR5 is an effective anti-HIV strategy, an...
- Thrombin-dependent NF-kappa B Activation and Monocyte/Endothelial Adhesion Are Mediated by the CARMA3.Bcl10.MALT1 Signalosome
[作者:Delekta, PC; Apel, IJ; Gu, SF; Siu, K; Hattori, Y; McAllister-Lucas, LM; Lucas, PC,期刊:Journal of Biological Chemistry, 页码:41432-41442 , 文章类型: Article,,卷期:2010年285-53]
- Thrombin is a potent modulator of endothelial function and, through stimulation of NF-kappa B, induces endothelial expression of intracellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1). ...
- The Transcriptionally Active Amyloid Precursor Protein (APP) Intracellular Domain Is Preferentially Produced from the 695 Isoform of APP in a beta-Secretase-dependent Pathway
[作者:Belyaev, ND; Kellett, KAB; Beckett, C; Makova, NZ; Revett, TJ; Nalivaeva, NN; Hooper, NM; Turner, AJ,期刊:Journal of Biological Chemistry, 页码:41443-41454 , 文章类型: Article,,卷期:2010年285-53]
- Amyloidogenic processing of the amyloid precursor protein (APP) by beta- and gamma-secretases generates several biologically active products, including amyloid-beta (A beta) and the APP intracellular domain (AICD). AICD ...
- CD300 Heterocomplexes, a New and Family-restricted Mechanism for Myeloid Cell Signaling Regulation
[作者:Martinez-Barriocanal, A; Comas-Casellas, E; Schwartz, S; Martin, M; Sayos, J,期刊:Journal of Biological Chemistry, 页码:41781-41794 , 文章类型: Article,,卷期:2010年285-53]
- The CD300 family of myeloid immunoglobulin receptors includes activating (CD300b, CD300e) and inhibitory members (CD300a, CD300f), as well as molecules of uncertain function presenting a negative charge within their tran...
- Protein Kinase C Phosphorylation Regulates Membrane Insertion of GABA(A) Receptor Subtypes That Mediate Tonic Inhibition
[作者:Abramian, AM; Comenencia-Ortiz, E; Vithlani, M; Tretter, EV; Sieghart, W; Davies, PA; Moss, SJ,期刊:Journal of Biological Chemistry, 页码:41795-41805 , 文章类型: Article,,卷期:2010年285-53]
- Tonic inhibition in the brain is mediated largely by specialized populations of extrasynaptic receptors, gamma-aminobutyric acid receptors (GABA(A)Rs). In the dentate gyrus region of the hippocampus, tonic inhibition is ...
- Probing the Active Site of the Deoxynucleotide N-Hydrolase Rcl Encoded by the Rat Gene c6orf108
[作者:Dupouy, C; Zhang, C; Padilla, A; Pochet, S; Kaminski, PA,期刊:Journal of Biological Chemistry, 页码:41806-41814 , 文章类型: Article,,卷期:2010年285-53]
- Rcl is a potential anti-angiogenic therapeutic target that hydrolyzes the N-glycosidic bond of 2'-deoxyribonucleoside 5'-monophosphate, yielding 2-deoxyribose 5-phosphate and the corresponding base. Its recently elucidat...
- Conserved Residues within the Putative S4-S5 Region Serve Distinct Functions among Thermosensitive Vanilloid Transient Receptor Potential (TRPV) Channels
[作者:Boukalova, S; Marsakova, L; Teisinger, J; Vlachova, V,期刊:Journal of Biological Chemistry, 页码:41455-41462 , 文章类型: Article,,卷期:2010年285-53]
- The vanilloid transient receptor potential channel TRPV1 is a tetrameric six-transmembrane segment (S1-S6) channel that can be synergistically activated by various proalgesic agents such as capsaicin, protons, heat, or h...
- New Functional Sulfide Oxidase-Oxygen Reductase Supercomplex in the Membrane of the Hyperthermophilic Bacterium Aquifex aeolicus
[作者:Prunetti, L; Infossi, P; Brugna, M; Ebel, C; Giudici-Orticoni, MT; Guiral, M,期刊:Journal of Biological Chemistry, 页码:41815-41826 , 文章类型: Article,,卷期:2010年285-53]
- Aquifex aeolicus, a hyperthermophilic and microaerophilic bacterium, obtains energy for growth from inorganic compounds alone. It was previously proposed that one of the respiratory pathways in this organism consists of ...
- Fetuin-A (alpha 2HS-Glycoprotein) Is a Major Serum Adhesive Protein That Mediates Growth Signaling in Breast Tumor Cells
[作者:Sakwe, AM; Koumangoye, R; Goodwin, SJ; Ochieng, J,期刊:Journal of Biological Chemistry, 页码:41827-41835 , 文章类型: Article,,卷期:2010年285-53]
- The identity of the cell adhesive factors in fetal bovine serum, commonly used to supplement growth media, remains a mystery due to the plethora of serum proteins. In the present analyses, we showed that fetuin-A, whose ...
- Intrinsic Linear Heterogeneity of Amyloid beta Protein Fibrils Revealed by Higher Resolution Mass-per-length Determinations
[作者:Komatsu, H; Feingold-Link, E; Sharp, KA; Rastogi, T; Axelsen, PH,期刊:Journal of Biological Chemistry, 页码:41843-41851 , 文章类型: Article,,卷期:2010年285-53]
- Amyloid beta proteins spontaneously form fibrils in vitro that vary in their thermodynamic stability and in morphological characteristics such as length, width, shape, longitudinal twist, and the number of component fila...
- Eosinophil Cysteinyl Leukotriene Synthesis Mediated by Exogenous Secreted Phospholipase A(2) Group X
[作者:Lai, Y; Oslund, RC; Bollinger, JG; Henderson, WR; Santana, LF; Altemeier, WA; Gelb, MH; Hallstrand, TS,期刊:Journal of Biological Chemistry, 页码:41491-41500 , 文章类型: Article,,卷期:2010年285-53]
- Secreted phospholipase A(2) group X (sPLA(2)-X) has recently been identified in the airways of patients with asthma and may participate in cysteinyl leukotriene (CysLT; C-4, D-4, and E-4) synthesis. We examined CysLT syn...
- Natural and Engineered Photoactivated Nucleotidyl Cyclases for Optogenetic Applications
[作者:Ryu, MH; Moskvin, OV; Siltberg-Liberles, J; Gomelsky, M,期刊:Journal of Biological Chemistry, 页码:41501-41508 , 文章类型: Article,,卷期:2010年285-53]
- Cyclic nucleotides, cAMP and cGMP, are ubiquitous second messengers that regulate metabolic and behavioral responses in diverse organisms. We describe purification, engineering, and characterization of photoactivated nuc...
|