- Synthesis and in vitro antiproliferative activity of 5-alkyl-12(H)-quino[3,4-b] [1,4] benzothiazinium salts
[作者:Zieba, A; Sochanik, A; Szurko, A; Rams, M; Mrozek, A; Cmoch, P,期刊:European Journal of Medicinal Chemistry, 页码:4733-4739 , 文章类型: Article,,卷期:2010年45-11]
- A novel method of synthesizing 1,4-thiazine ring has led to the series of 5-alkyl-12(H)-quino[3,4-b][1,4] benzothiazinium salts. The derivatives containing a butyl or decyl substituents on the quinoline nitrogen atom wer...
- Synthesis and screening of some novel fused thiophene and thienopyrimidine derivatives for anti-avian influenza virus (H5N1) activity
[作者:Rashad, AE; Shamroukh, AH; Abdel-Megeid, RE; Mostafa, A; El-Shesheny, R; Kandeil, A; Ali, MA; Banert, K,期刊:European Journal of Medicinal Chemistry, 页码:5251-5257 , 文章类型: Article,,卷期:2010年45-11]
- Several derivatives containing dihydronaphtho, naphtho[2,1-b]thiophene and thieno[2,3-d]pyrimidine ring systems were prepared starting from 2-amino-4,5-dihydronaphtho[2,1-b]thiophene-1-carbonitrile (1). Structure charact...
- Efficient synthesis of novel 1,2,4-triazole fused acyclic and 21-28 membered macrocyclic and/or lariat macrocyclic oxaazathia crown compounds with potential antimicrobial activity
[作者:Khalil, NSAM,期刊:European Journal of Medicinal Chemistry, 页码:5265-5277 , 文章类型: Article,,卷期:2010年45-11]
- Versatile simple efficient routes with good to excellent yields towards different functionalized 1,omega-bis (1,2,4-triazoles), 21-28 membered 1,2,4-triazole fused macrocyclic and/or lariat macrocyclic oxaazathia crown S...
- Synthesis, cytotoxic activities and DNA binding properties of beta-carboline derivatives
[作者:Chen, ZY; Cao, RH; Yu, LA; Shi, BX; Sun, J; Guo, LA; Ma, Q; Yi, W; Song, XA; Song, HC,期刊:European Journal of Medicinal Chemistry, 页码:4740-4745 , 文章类型: Article,,卷期:2010年45-11]
- In a continuing effort to develop novel beta-carbolines endowed with better pharmacological profile, a series of water-soluble beta-carbolines bearing a flexible amino side chain was designed and synthesized, and the cyt...
- Computational analysis of ligand recognition sites of homo- and heteropentameric 5-HT3 receptors
[作者:Barbosa, AJM; De Rienzo, F; Ramos, MJ; Menziani, MC,期刊:European Journal of Medicinal Chemistry, 页码:4746-4760 , 文章类型: Article,,卷期:2010年45-11]
- Inhibition of the 5-hydroxytryptamine receptor (5-HT3R), a member of the Cys-loop superfamily of Ligand-Gated Ion Channels (LGICs), has been recognized to have important antiemetic effects. With respect to the many other...
- Synthesis and biological evaluation of N-antipyrine-4-substituted amino-3-chloromaleimide derivatives
[作者:Mahle, F; Guimaraes, TD; Meira, AV; Correa, R; Cruz, RCB; Cruz, AB; Nunes, RJ; Cechinel, V; de Campos-Buzzi, F,期刊:European Journal of Medicinal Chemistry, 页码:4761-4768 , 文章类型: Article,,卷期:2010年45-11]
- This paper describes the synthesis of new cyclic imides obtained by reaction with N-antipyrine-3,4-dichloromaleimides and different aromatic amines. The analgesic activity of the synthesized compounds was initially inves...
- Synthesis and antitumor activity of novel 6-aryl and 6-alkylpyrazolo[3,4-d] pyrimidin-4-one derivatives
[作者:El-Enany, MM; Kamel, MM; Khalil, OM; El-Nassan, HB,期刊:European Journal of Medicinal Chemistry, 页码:5286-5291 , 文章类型: Article,,卷期:2010年45-11]
- A series of new 6-arylpyrazolo[3,4-d]pyrimidin-4-ones and 6-alkylpyrazolo[3,4-d]pyrimidin-4-ones were synthesized. Some of the newly synthesized compounds were tested in vitro on human colon tumor cell line (HCT116). Mos...
- Reinvestigation of structure-activity relationship of methoxylated chalcones as antimalarials: Synthesis and evaluation of 2,4,5-trimethoxy substituted patterns as lead candidates derived from abundantly available natural beta-asarone
[作者:Kumar, R; Mohanakrishnan, D; Sharma, A; Kaushik, NK; Kalia, K; Sinha, AK; Sahal, D,期刊:European Journal of Medicinal Chemistry, 页码:5292-5301 , 文章类型: Article,,卷期:2010年45-11]
- We have examined the antimalarial structure-activity relationship of a series of methoxylated chalcones (A-CH=CH-CO-B) against Plasmodium falciparum (3D7 strain) using fluorescence-based SYBR Green assay. Our study has r...
- Synthesis, DNA binding and cleavage activity of macrocyclic polyamines bearing mono- or bis-acridine moieties
[作者:Liu, QA; Zhang, J; Wang, MQ; Zhang, DW; Lu, QS; Huang, Y; Lin, HH; Yu, XQ,期刊:European Journal of Medicinal Chemistry, 页码:5302-5308 , 文章类型: Article,,卷期:2010年45-11]
- Two acridine-pendant cyclen (1,4,7,10-tetraazacyclododecane) derivatives 1 and 2 were synthesized, and their DNA interactions have been systematically investigated by UV absorption, fluorescence titration, viscosity meas...
- Synthesis, characterization and antiglaucoma activity of some novel pyrazole derivatives of 5-amino-1,3,4-thiadiazole-2-sulfonamide
[作者:Kasimogullari, R; Bulbul, M; Arslan, BS; Gokce, B,期刊:European Journal of Medicinal Chemistry, 页码:4769-4773 , 文章类型: Article,,卷期:2010年45-11]
- Pyrazole carboxylic acid derivatives of 5-amino-1,3,4-thiadiazole-2-sulfonamide (inhibitor 1) were synthesized from ethyl 3-(chlorocarbonyl)-1-(3-nitrophenyl)-5-phenyl-1H-pyrazole-4-carboxylate compound. The inhibitory e...
- Synthesis and molluscicidal evaluation of some new pyrazole, isoxazole, pyridine, pyrimidine, 1,4-thiazine and 1,3,4-thiadiazine derivatives incorporating benzofuran moiety
[作者:El Shehry, MF; Swellem, RH; Abu-Bakr, SM; El-Telbani, EM,期刊:European Journal of Medicinal Chemistry, 页码:4783-4787 , 文章类型: Article,,卷期:2010年45-11]
- Chalcone derivative 3 was synthesized via the base catalyzed Claisen-Schmidt condensation and was used as a precursor for synthesizing pyrazoline 11, isoxazoline 12, pyrazoline carbothioamide 13, 5,6-dihydropyrimidine-2-...
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