- Active Site Mutations in Mammalian DNA Polymerase delta Alter Accuracy and Replication Fork Progression
[作者:Schmitt, MW; Venkatesan, RN; Pillaire, MJ; Hoffmann, JS; Sidorova, JM; Loeb, LA,期刊:Journal of Biological Chemistry, 页码:32264-32272 , 文章类型: Article,,卷期:2010年285-42]
- DNA polymerase delta (pol delta) is one of the two main replicative polymerases in eukaryotes; it synthesizes the lagging DNA strand and also functions in DNA repair. In previous work, we demonstrated that heterozygous e...
- ATP-Citrate Lyase Reduction Mediates Palmitate-induced Apoptosis in Pancreatic Beta Cells
[作者:Chu, KY; Lin, YL; Hendel, A; Kulpa, JE; Brownsey, RW; Johnson, JD,期刊:Journal of Biological Chemistry, 页码:32606-32615 , 文章类型: Article,,卷期:2010年285-42]
Elevated extracellular lipids, such as the free fatty acid palmitate, can induce pancreatic beta cell endoplasmic reticulum (ER) stress and apoptosis, thereby contributing to the initiation and progression of type 2 d...
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