- An efficient one-pot synthesis of heterocycle-fused 1,2,3-triazole derivatives as anti-cancer agents
[作者:Yan, SJ; Liu, YJ; Chen, YL; Liu, L; Lin, J,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:5225-5228 , 文章类型: Article,,卷期:2010年20-17]
- A series of heterocycle-fused 1,2,3-triazoles were easily prepared by the 1,3-dipolar cycloaddition of heterocyclic ketene aminals or N,O-acetals with sodium azide and polyhalo isophthalonitriles in a one-pot reaction at...
- Synthesis of 3,3-diindolyl oxyindoles efficiently catalysed by FeCl3 and their in vitro evaluation for anticancer activity
[作者:Kamal, A; Srikanth, YVV; Khan, MNA; Shaik, TB; Ashraf, M,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:5229-5231 , 文章类型: Article,,卷期:2010年20-17]
- A simple and highly efficient method has been developed for the synthesis of 3,3-diindolyl oxyindoles by the reaction of indoles with isatin or 5-fluoro isatin using a catalytic amount (5 mol %) of FeCl3 at room temperat...
- Synthesis and biological evaluation of anilino substituted pyrimidine linked pyrrolobenzodiazepines as potential anticancer agents
[作者:Kamal, A; Reddy, JS; Ramaiah, MJ; Bharathi, EV; Dastagiri, D; Reddy, MK; Pushpavalli, SNCVL; Pal-Bhadra, M,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:5232-5236 , 文章类型: Article,,卷期:2010年20-17]
- A series of new anilino substituted pyrimidine linked pyrrolo[2,1-c][1,4] benzodiazepine (PBD) conjugates were prepared and evaluated for their anticancer activity. The effects of four promising PBD conjugates on cell cy...
- Novel 1H-pyrrolo[2,3-c]pyridines as acid pump antagonists (APAs)
[作者:Yoon, YA; Kim, DH; Lee, BM; Kim, TK; Cha, MH; Sim, JY; Kim, JG,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:5237-5240 , 文章类型: Article,,卷期:2010年20-17]
- A series of 1H-pyrrolo[2,3-c]pyridines as acid pump antagonists (APAs) was synthesized and the inhibitory activities against H+/K+ ATPase isolated from hog gastric mucosa were determined. After elaborating on substituent...
- Hit-to-lead optimization of a series of carboxamides of ethyl 2-amino-4-phenylthiazole-5-carboxylates as novel adenosine A(2A) receptor antagonists
[作者:Sams, AG; Mikkelsen, GK; Larsen, M; Torup, L; Brennum, LT; Schroder, TJ; Bang-Andersen, B,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:5241-5244 , 文章类型: Article,,卷期:2010年20-17]
- Herein we describe the discovery of a series of novel adenosine A(2A) receptor antagonists. A successful hit-to-lead optimization of an HTS hit led to replacement of a metabolically labile ester moiety with a heteroaroma...
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