- Role of the Bering Strait on the hysteresis of the ocean conveyor belt circulation and glacial climate stability
[作者：Hu, AX; Meehl, GA; Han, WQ; Timmermann, A; Otto-Bliesner, B; Liu, ZY; Washington, WM; Large, W; Abe-Ouchi, A; Kimoto, M; Lambeck, K; Wu, BY,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：6417-6422 , 文章类型： Article，,卷期：2012年109-17]
- Abrupt climate transitions, known as Dansgaard-Oeschger and Heinrich events, occurred frequently during the last glacial period, specifically from 80-11 thousand years before present, but were nearly absent during interg...
- Antarctic and Southern Ocean influences on Late Pliocene global cooling
[作者：McKay, R; Naish, T; Carter, L; Riesselman, C; Dunbar, R; Sjunneskog, C; Winter, D; Sangiorgi, F; Warren, C; Pagani, M; Schouten, S; Willmott, V; Levy, R; DeConto, R; Powell, RD,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：6423-6428 , 文章类型： Article，,卷期：2012年109-17]
- The influence of Antarctica and the Southern Ocean on Late Pliocene global climate reconstructions has remained ambiguous due to a lack of well-dated Antarctic-proximal, paleoenvironmental records. Here we present ice sh...
- Antibody therapy targeting the CD47 protein is effective in a model of aggressive metastatic leiomyosarcoma
[作者：Edris, B; Weiskopf, K; Volkmer, AK; Volkmer, JP; Willingham, SB; Contreras-Trujillo, H; Liu, J; Majeti, R; West, RB; Fletcher, JA; Beck, AH; Weissman, IL; van de Rijn, M,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：6656-6661 , 文章类型： Article，,卷期：2012年109-17]
- Antibodies against CD47, which block tumor cell CD47 interactions with macrophage signal regulatory protein-a, have been shown to decrease tumor size in hematological and epithelial tumor models by interfering with the p...
- Crystal structure of Staphylococcus aureus transglycosylase in complex with a lipid II analog and elucidation of peptidoglycan synthesis mechanism
[作者：Huang, CY; Shih, HW; Lin, LY; Tien, YW; Cheng, TJR; Cheng, WC; Wong, CH; Ma, C,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：6496-6501 , 文章类型： Article，,卷期：2012年109-17]
- Bacterial transpeptidase and transglycosylase on the surface are essential for cell wall synthesis, and many antibiotics have been developed to target the transpeptidase; however, the problem of antibiotic resistance has...
- Fire-free land use in pre-1492 Amazonian savannas
[作者：Iriarte, J; Power, MJ; Rostain, S; Mayle, FE; Jones, H; Watling, J; Whitney, BS; Mckey, DB,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：6473-6478 , 文章类型： Article，,卷期：2012年109-17]
- The nature and scale of pre-Columbian land use and the consequences of the 1492 "Columbian Encounter" (CE) on Amazonia are among the more debated topics in New World archaeology and paleoecology. However, pre-Columbian h...
- Introducing endo-xylanase activity into an exo-acting arabinofuranosidase that targets side chains
[作者：Mckee, LS; Pena, MJ; Rogowski, A; Jackson, A; Lewis, RJ; York, WS; Krogh, KBRM; Vikso-Nielsen, A; Skjot, M; Gilbert, HJ; Marles-Wright, J,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：6537-6542 , 文章类型： Article，,卷期：2012年109-17]
- The degradation of the plant cell wall by glycoside hydrolases is central to environmentally sustainable industries. The major polysaccharides of the plant cell wall are cellulose and xylan, a highly decorated beta-1,4-x...
- The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis
[作者：Rajurkar, M; De Jesus-Monge, WE; Driscoll, DR; Appleman, VA; Huang, H; Cotton, JL; Klimstra, DS; Zhu, LHJ; Simin, K; Xu, L; McMahon, AP; Lewis, BC; Mao, JH,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：E1038-E1047 , 文章类型： Article，,卷期：2012年109-17]
- Pancreatic ductal adenocarcinoma (PDAC), one of the most aggressive human malignancies, is thought to be initiated by KRAS activation. Here we find that transcriptional activation mediated by the Gli family of transcript...
- The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors
[作者：Willingham, SB; Volkmer, JP; Gentles, AJ; Sahoo, D; Dalerba, P; Mitra, SS; Wang, J; Contreras-Trujillo, H; Martin, R; Cohen, JD; Lovelace, P; Scheeren, FA; Chao, MP; Weiskopf, K; Tang, C; Volkmer, AK; Naik, TJ; Storm, TA; Mosley, AR; Edris, B; Schmid, SM; Sun, CK; Chua, MS; Murillo, O; Rajendran, P; Cha, AC; Chin, RK; Kim, D; Adorno, M; Raveh, T; Tseng, D; Jaiswal, S; Enger, PO; Steinberg, GK; Li, G; So, SK; Majeti, R; Harsh, GR; van de Rijn, M; Teng, NNH; Sunwoo, JB; Alizadeh, AA; Clarke, MF; Weissman, IL,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：6662-6667 , 文章类型： Article，,卷期：2012年109-17]
- CD47, a "don't eat me" signal for phagocytic cells, is expressed on the surface of all human solid tumor cells. Analysis of patient tumor and matched adjacent normal (nontumor) tissue revealed that CD47 is overexpressed ...
- Anticancer drug oxaliplatin induces acute cooling-aggravated neuropathy via sodium channel subtype Na(V)1.6-resurgent and persistent current
[作者：Sittl, R; Lampert, A; Huth, T; Schuy, ET; Link, AS; Fleckenstein, J; Alzheimer, C; Grafe, P; Carr, RW,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：6704-6709 , 文章类型： Article，,卷期：2012年109-17]
- Infusion of the chemotherapeutic agent oxaliplatin leads to an acute and a chronic form of peripheral neuropathy. Acute oxaliplatin neuropathy is characterized by sensory paresthesias and muscle cramps that are notably e...
- De novo design of synthetic prion domains
[作者：Toombs, JA; Petri, M; Paul, KR; Kan, GY; Ben-Hur, A; Ross, ED,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：6519-6524 , 文章类型： Article，,卷期：2012年109-17]
- Prions are important disease agents and epigenetic regulatory elements. Prion formation involves the structural conversion of proteins from a soluble form into an insoluble amyloid form. In many cases, this structural co...
- Footprints of positive selection associated with a mutation (N1575Y) in the voltage-gated sodium channel of Anopheles gambiae
[作者：Jones, CM; Liyanapathirana, M; Agossa, FR; Weetman, D; Ranson, H; Donnelly, MJ; Wilding, CS,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：6614-6619 , 文章类型： Article，,卷期：2012年109-17]
- Insecticide resistance is an ideal model to study the emergence and spread of adaptative variants. In the African malaria mosquito, Anopheles gambiae, this is complemented by a strong public health rationale. In this ins...
- Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation
[作者：Haldar, SM; Jeyaraj, D; Anand, P; Zhu, H; Lu, Y; Prosdocimo, DA; Eapen, B; Kawanami, D; Okutsu, M; Brotto, L; Fujioka, H; Kerner, J; Rosca, MG; McGuinness, OP; Snow, RJ; Russell, AP; Gerber, AN; Bai, XD; Yan, Z; Nosek, TM; Brotto, M; Hoppel, CL; Jain, MK,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：6739-6744 , 文章类型： Article，,卷期：2012年109-17]
- The ability of skeletal muscle to enhance lipid utilization during exercise is a form of metabolic plasticity essential for survival. Conversely, metabolic inflexibility in muscle can cause organ dysfunction and disease....
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