- Congenital diaphragmatic hernia candidate genes derived from embryonic transcriptomes
[作者:Russell, MK; Longoni, M; Wells, J; Maalouf, FI; Tracy, AA; Loscertales, M; Ackerman, KG; Pober, BR; Lage, K; Bult, CJ; Donahoe, PK,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2978-2983 , 文章类型: Article,,卷期:2012年109-8]
- Congenital diaphragmatic hernia (CDH) is a common (1 in 3,000 live births) major congenital malformation that results in significant morbidity and mortality. The discovery of CDH loci using standard genetic approaches ha...
- Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)
[作者:McCabe, MT; Graves, AP; Ganji, G; Diaz, E; Halsey, WS; Jiang, Y; Smitheman, KN; Ott, HM; Pappalardi, MB; Allen, KE; Chen, SB; Della Pietra, A; Dul, E; Hughes, AM; Gilbert, SA; Thrall, SH; Tummino, PJ; Kruger, RG; Brandt, M; Schwartz, B; Creasy, CL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2989-2994 , 文章类型: Article,,卷期:2012年109-8]
- Trimethylation of histone H3 on lysine 27 (H3K27me3) is a repressive posttranslational modification mediated by the histone methyltransferase EZH2. EZH2 is a component of the polycomb repressive complex 2 and is overexpr...
- Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria
[作者:Kamileri, I; Karakasilioti, I; Sideri, A; Kosteas, T; Tatarakis, A; Talianidis, I; Garinis, GA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2995-3000 , 文章类型: Article,,卷期:2012年109-8]
- Nucleotide excision repair (NER) defects are associated with cancer, developmental disorders and neurodegeneration. However, with the exception of cancer, the links between defects in NER and developmental abnormalities ...
- IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist
[作者:van de Veerdonk, FL; Stoeckman, AK; Wu, GP; Boeckermann, AN; Azam, T; Netea, MG; Joosten, LAB; van der Meer, JWM; Hao, RY; Kalabokis, V; Dinarello, CA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3001-3005 , 文章类型: Article,,卷期:2012年109-8]
- The functional role of IL-1 family member 10, recently renamed IL-38, remains unknown. In the present study we aimed to elucidate the biological function of IL-38 and to identify its receptor. Heat-killed Candida albican...
- Protein phosphatase 1 subunit Ppp1r15a/GADD34 regulates cytokine production in polyinosinic: polycytidylic acid-stimulated dendritic cells
[作者:Clavarino, G; Claudio, N; Dalet, A; Terawaki, S; Couderc, T; Chasson, L; Ceppi, M; Schmidt, EK; Wenger, T; Lecuit, M; Gatti, E; Pierre, P,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3006-3011 , 文章类型: Article,,卷期:2012年109-8]
- In response to inflammatory stimulation, dendritic cells (DCs) have a remarkable pattern of differentiation that exhibits specific mechanisms to control the immune response. Here we show that in response to polyriboinosi...
- Plasmacytoid dendritic cells control T-cell response to chronic viral infection
[作者:Cervantes-Barragan, L; Lewis, KL; Firner, S; Thiel, V; Hugues, S; Reith, W; Ludewig, B; Reizis, B,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3012-3017 , 文章类型: Article,,卷期:2012年109-8]
- Infections with persistent viruses are a frequent cause of immunosuppression, autoimmune sequelae, and/or neoplastic disease. Plasmacytoid dendritic cells (pDCs) are innate immune cells that produce type I interferon (IF...
- Phosphorylation of dedicator of cytokinesis 1 (Dock180) at tyrosine residue Y722 by Src family kinases mediates EGFRvIII-driven glioblastoma tumorigenesis
[作者:Feng, HZ; Hu, B; Jarzynka, MJ; Li, YX; Keezer, S; Johns, TG; Tang, CK; Hamilton, RL; Vuori, K; Nishikawa, R; Sarkaria, JN; Fenton, T; Cheng, T; Furnari, FB; Cavenee, WK; Cheng, SY,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3018-3023 , 文章类型: Article,,卷期:2012年109-8]
- Glioblastoma, the most common primary malignant cancer of the brain, is characterized by rapid tumor growth and infiltration of tumor cells throughout the brain. These traits cause glioblastomas to be highly resistant to...
- Breast cancer signatures for invasiveness and prognosis defined by deep sequencing of microRNA
[作者:Volinia, S; Galasso, M; Sana, ME; Wise, TF; Palatini, J; Huebner, K; Croce, CM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3024-3029 , 文章类型: Article,,卷期:2012年109-8]
- The transition from ductal carcinoma in situ to invasive ductal carcinoma is a key event in breast cancer progression that is still not well understood. To discover the microRNAs regulating this critical transition, we u...
- Central diabetes insipidus associated with impaired renal aquaporin-1 expression in mice lacking liver X receptor beta
[作者:Gabbi, C; Kong, XM; Suzuki, H; Kim, HJ; Gao, M; Jia, X; Ohnishi, H; Ueta, Y; Warner, M; Guan, YF; Gustafsson, JA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3030-3034 , 文章类型: Article,,卷期:2012年109-8]
- The present study demonstrates a key role for the oxysterol receptor liver X receptor beta (LXR beta) in the etiology of diabetes insipidus (DI). Given free access to water, LXR beta(-/-) but not LXR alpha(-/-) mice exhi...
- Role of retroviral restriction factors in the interferon-alpha-mediated suppression of HIV-1 in vivo
[作者:Pillai, SK; Abdel-Mohsen, M; Guatelli, J; Skasko, M; Monto, A; Fujimoto, K; Yukl, S; Greene, WC; Kovari, H; Rauch, A; Fellay, J; Battegay, M; Hirschel, B; Witteck, A; Bernasconi, E; Ledergerber, B; Gunthard, HF; Wong, JK,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3035-3040 , 文章类型: Article,,卷期:2012年109-8]
- The antiviral potency of the cytokine IFN-alpha has been long appreciated but remains poorly understood. A number of studies have suggested that induction of the apolipoprotein B mRNA editing enzyme, catalytic polypeptid...
- Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response
[作者:Szerlip, NJ; Pedraza, A; Chakravarty, D; Azim, M; McGuire, J; Fang, YQ; Ozawa, T; Holland, EC; Huse, JT; Jhanwar, S; Leversha, MA; Mikkelsen, T; Brennan, CW,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3041-3046 , 文章类型: Article,,卷期:2012年109-8]
- Glioblastoma (GBM) is distinguished by a high degree of intra-tumoral heterogeneity, which extends to the pattern of expression and amplification of receptor tyrosine kinases (RTKs). Although most GBMs harbor RTK amplifi...
- Essential requirement for beta-arrestin2 in mouse intestinal tumors with elevated Wnt signaling
[作者:Bonnans, C; Flaceliere, M; Grillet, F; Dantec, C; Desvignes, JP; Pannequin, J; Severac, D; Dubois, E; Bibeau, F; Escriou, V; Crespy, P; Journot, L; Hollande, F; Joubert, D,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3047-3052 , 文章类型: Article,,卷期:2012年109-8]
- beta-Arrestins (Arrb) participate in the regulation of multiple signaling pathways, including Wnt/beta-catenin, the major actor in human colorectal cancer initiation. To better understand the roles of Arrb in intestinal ...
- Inactivation of androgen-induced regulator ARD1 inhibits androgen receptor acetylation and prostate tumorigenesis
[作者:Wang, ZH; Wang, ZM; Guo, JH; Li, YC; Bavarva, JH; Qian, CP; Brahimi-Horn, C; Tan, DY; Liu, WG,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3053-3058 , 文章类型: Article,,卷期:2012年109-8]
- Androgen signaling through androgen receptor (AR) is critical for prostate tumorigenesis. Given that AR-mediated gene regulation is enhanced by AR coregulators, inactivation of those coregulators is emerging as a promisi...
- Feedback upregulation of HER3 (ErbB3) expression and activity attenuates antitumor effect of PI3K inhibitors
[作者:Chakrabarty, A; Sanchez, V; Kuba, MG; Rinehart, C; Arteaga, CL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2718-2723 , 文章类型: Article,,卷期:2012年109-8]
- We examined the effects of an inhibitor of PI3K, XL147, against human breast cancer cell lines with constitutive PI3K activation. Treatment with XL147 resulted in dose-dependent inhibition of cell growth and levels of pA...
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