- Yeast mitochondrial threonyl-tRNA synthetase recognizes tRNA isoacceptors by distinct mechanisms and promotes CUN codon reassignment
[作者:Ling, JQ; Peterson, KM; Simonovic, I; Cho, C; Soll, D; Simonovic, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3281-3286 , 文章类型: Article,,卷期:2012年109-9]
- Aminoacyl-tRNA synthetases (aaRSs) ensure faithful translation of mRNA into protein by coupling an amino acid to a set of tRNAs with conserved anticodon sequences. Here, we show that in mitochondria of Saccharomyces cere...
- Composite low affinity interactions dictate recognition of the cyclin-dependent kinase inhibitor Sic1 by the SCFCdc4 ubiquitin ligase
[作者:Tang, XJ; Orlicky, S; Mittag, T; Csizmok, V; Pawson, T; Forman-Kay, JD; Sicheri, F; Tyers, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3287-3292 , 文章类型: Article,,卷期:2012年109-9]
- The ubiquitin ligase SCFCdc4 (Skp1/Cul1/F-box protein) recognizes its substrate, the cyclin-dependent kinase inhibitor Sic1, in a multisite phosphorylation-dependent manner. Although short diphosphorylated peptides deriv...
- Forkhead box N4 (Foxn4) activates Dll4-Notch signaling to suppress photoreceptor cell fates of early retinal progenitors
[作者:Luo, HJ; Jin, KX; Xie, ZH; Qiu, F; Li, SG; Zou, M; Cai, L; Hozumi, K; Shima, DT; Xiang, MQ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E553-E562 , 文章类型: Article,,卷期:2012年109-9]
- The generation of diverse neuronal types and subtypes from multipotent progenitors during development is crucial for assembling functional neural circuits in the adult central nervous system. During mouse retinogenesis, ...
- Long-term perspective on wildfires in the western USA
[作者:Marlon, JR; Bartlein, PJ; Gavin, DG; Long, CJ; Anderson, RS; Briles, CE; Brown, KJ; Colombaroli, D; Hallett, DJ; Power, MJ; Scharf, EA; Walsh, MK,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E535-E543 , 文章类型: Article,,卷期:2012年109-9]
- Understanding the causes and consequences of wildfires in forests of the western United States requires integrated information about fire, climate changes, and human activity on multiple temporal scales. We use sedimenta...
- Childhood maltreatment is associated with reduced volume in the hippocampal subfields CA3, dentate gyrus, and subiculum
[作者:Teicher, MH; Anderson, CM; Polcari, A,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E563-E572 , 文章类型: Article,,卷期:2012年109-9]
- Childhood maltreatment or abuse is a major risk factor for mood, anxiety, substance abuse, psychotic, and personality disorders, and it is associated with reduced adult hippocampal volume, particularly on the left side. ...
- Thioredoxin-insensitive plastid ATP synthase that performs moonlighting functions
[作者:Kohzuma, K; Dal Bosco, C; Kanazawa, A; Dhingra, A; Nitschke, W; Meurer, J; Kramer, DM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3293-3298 , 文章类型: Article,,卷期:2012年109-9]
- The chloroplast ATP synthase catalyzes the light-driven synthesis of ATP and acts as a key feedback regulatory component of photosynthesis. Arabidopsis possesses two homologues of the regulatory gamma subunit of the ATP ...
- Design of a binding scaffold based on variable lymphocyte receptors of jawless vertebrates by module engineering
[作者:Lee, SC; Park, K; Han, J; Lee, JJ; Kim, HJ; Hong, S; Heu, W; Kim, YJ; Ha, JS; Lee, SG; Cheong, HK; Jeon, YH; Kim, D; Kim, HS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3299-3304 , 文章类型: Article,,卷期:2012年109-9]
- Repeat proteins have recently been of great interest as potential alternatives to immunoglobulin antibodies due to their unique structural and biophysical features. We here present the development of a binding scaffold b...
- Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms
[作者:Hanawa-Suetsugu, K; Kukimoto-Niino, M; Mishima-Tsumagari, C; Akasaka, R; Ohsawa, N; Sekine, S; Ito, T; Tochio, N; Koshiba, S; Kigawa, T; Terada, T; Shirouzu, M; Nishikimi, A; Uruno, T; Katakai, T; Kinashi, T; Kohda, D; Fukui, Y; Yokoyama, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3305-3310 , 文章类型: Article,,卷期:2012年109-9]
- DOCK2, a hematopoietic cell-specific, atypical guanine nucleotide exchange factor, controls lymphocyte migration through ras-related C3 botulinum toxin substrate (Rac) activation. Dedicator of cytokinesis 2-engulfment an...
- Unwinding the differences of the mammalian PERIOD clock proteins from crystal structure to cellular function
[作者:Kucera, N; Schmalen, I; Hennig, S; Ollinger, R; Strauss, HM; Grudziecki, A; Wieczorek, C; Kramer, A; Wolf, E,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3311-3316 , 文章类型: Article,,卷期:2012年109-9]
- The three PERIOD homologues mPER1, mPER2, and mPER3 constitute central components of the mammalian circadian clock. They contain two PAS (PER-ARNT-SIM) domains (PAS-A and PAS-B), which mediate homo- and heterodimeric mPE...
- A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage
[作者:Bach, A; Clausen, BH; Moller, M; Vestergaard, B; Chi, CN; Round, A; Sorensen, PL; Nissen, KB; Kastrup, JS; Gajhede, M; Jemth, P; Kristensen, AS; Lundstrom, P; Lambertsen, KL; Stromgaard, K,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3317-3322 , 文章类型: Article,,卷期:2012年109-9]
- Inhibition of the ternary protein complex of the synaptic scaffolding protein postsynaptic density protein-95 (PSD-95), neuronal nitric oxide synthase (nNOS), and the N-methyl-D-aspartate (NMDA) receptor is a potential s...
- Two-dimensional IR spectroscopy and segmental C-13 labeling reveals the domain structure of human gamma D-crystallin amyloid fibrils
[作者:Moran, SD; Woys, AM; Buchanan, LE; Bixby, E; Decatur, SM; Zanni, MT,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3329-3334 , 文章类型: Article,,卷期:2012年109-9]
- The structural eye lens protein gamma D-crystallin is a major component of cataracts, but its conformation when aggregated is unknown. Using expressed protein ligation, we uniformly C-13 labeled one of the two Greek key ...
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