- Eosinophil-derived leukotriene C4 signals via type 2 cysteinyl leukotriene receptor to promote skin fibrosis in a mouse model of atopic dermatitis
[作者:Oyoshi, MK; He, R; Kanaoka, Y; ElKhal, A; Kawamoto, S; Lewis, CN; Austen, KF; Geha, RS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:4992-4997 , 文章类型: Article,,卷期:2012年109-13]
- Atopic dermatitis (AD) skin lesions exhibit epidermal and dermal thickening, eosinophil infiltration, and increased levels of the cysteinyl leukotriene (cys-LT) leukotriene C-4 (LTC4). Epicutaneous sensitization with ova...
- Identification of a common immune signature in murine and human systemic Salmonellosis
[作者:Lee, SJ; Liang, L; Juarez, S; Nanton, MR; Gondwe, EN; Msefula, CL; Kayala, MA; Necchi, F; Heath, JN; Hart, P; Tsolis, RM; Heyderman, RS; MacLennan, CA; Felgner, PL; Davies, DH; McSorley, SJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:4998-5003 , 文章类型: Article,,卷期:2012年109-13]
- Despite the importance of Salmonella infections in human and animal health, the target antigens of Salmonella-specific immunity remain poorly defined. We have previously shown evidence for antibody-mediating protection a...
- Signal transducer and activator of transcription-3/suppressor of cytokine signaling-3 (STAT3/SOCS3) axis in myeloid cells regulates neuroinflammation
[作者:Qin, HW; Yeh, WI; De Sarno, P; Holdbrooks, AT; Liu, YD; Muldowney, MT; Reynolds, SL; Yanagisawa, LL; Fox, TH; Park, K; Harrington, LE; Raman, C; Benveniste, EN,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5004-5009 , 文章类型: Article,,卷期:2012年109-13]
- Suppressor of cytokine signaling (SOCS) proteins are feedback inhibitors of the JAK/STAT pathway. SOCS3 has a crucial role in inhibiting STAT3 activation, cytokine signaling, and inflammatory gene expression in macrophag...
- Intestinal CX3C chemokine receptor 1(high) (CX(3)CR1(high)) myeloid cells prevent T-cell-dependent colitis
[作者:Kayama, H; Ueda, Y; Sawa, Y; Jeon, SG; Ma, JS; Okumura, R; Kubo, A; Ishii, M; Okazaki, T; Murakami, M; Yamamoto, M; Yagita, H; Takeda, K,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5010-5015 , 文章类型: Article,,卷期:2012年109-13]
- Adequate activation of CD4(+) T lymphocytes is essential for host defense against invading pathogens; however, exaggerated activity of effector CD4(+) T cells induces tissue damage, leading to inflammatory disorders such...
- Cytotoxicity of a Ti(IV) compound is independent of serum proteins
[作者:Tinoco, AD; Thomas, HR; Incarvito, CD; Saghatelian, A; Valentine, AM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5016-5021 , 文章类型: Article,,卷期:2012年109-13]
- Titanium(IV) compounds are excellent anticancer drug candidates, but they have yet to find success in clinical applications. A major limitation in developing further compounds has been a general lack of understanding of ...
- Improvement of islet function in a bioartificial pancreas by enhanced oxygen supply and growth hormone releasing hormone agonist
[作者:Ludwig, B; Rotem, A; Schmid, J; Weir, GC; Colton, CK; Brendel, MD; Neufeld, T; Block, NL; Yavriyants, K; Steffen, A; Ludwig, S; Chavakis, T; Reichel, A; Azarov, D; Zimermann, B; Maimon, S; Balyura, M; Rozenshtein, T; Shabtay, N; Vardi, P; Bloch, K; de Vos, P; Schally, AV; Bornstein, SR; Barkai, U,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5022-5027 , 文章类型: Article,,卷期:2012年109-13]
- Islet transplantation is a feasible therapeutic alternative for metabolically labile patients with type 1 diabetes. The primary therapeutic target is stable glycemic control and prevention of complications associated wit...
- Polycomb repressive complex 2 is required for MLL-AF9 leukemia
[作者:Neff, T; Sinha, AU; Kluk, MJ; Zhu, N; Khattab, MH; Stein, L; Xie, HF; Orkin, SH; Armstrong, SA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5028-5033 , 文章类型: Article,,卷期:2012年109-13]
- A growing body of data suggests the importance of epigenetic mechanisms in cancer. Polycomb repressive complex 2 (PRC2) has been implicated in self-renewal and cancer progression, and its components are overexpressed in ...
- Postexposure antibody prophylaxis protects nonhuman primates from filovirus disease
[作者:Dye, JM; Herbert, AS; Kuehne, AI; Barth, JF; Muhammad, MA; Zak, SE; Ortiz, RA; Prugar, LI; Pratt, WD,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5034-5039 , 文章类型: Article,,卷期:2012年109-13]
- Antibody therapies to prevent or limit filovirus infections have received modest interest in recent years, in part because of early negative experimental evidence. We have overcome the limitations of this approach, lever...
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